The transport properties of benzoic acid and its eighteen derivatives such as o-, m-or p-hydroxybenzoic acid (o-, m-or p-HBA), aminobenzoic acid (o-, m-or p-ABA), toluic acid (o-, m-or p-TA), fluorobenzoic acid (o-, m-or p-FBA), chlorobenzoic acid (o-, m-or p-CBA) and bromobenzoic acid (o-, m-or p-BBA) through human erythrocyte membranes were examined. The drugs having a hydrophilic ortho-substituent and those having a hydrophobic meta-or para-substituent showed higher transport. The ratio of free drugs in erythrocytes, fu
R, did not relate to the partition coefficient (P). However, fu
M (the ratio of free drugs in the plasma) and K
p. (the ratio of partition between erythrocytes and plasma) related to the P : fu
M=-0.3128×log P+0.9727 (R
2=0.8722
***), K
p=-0.2558×log P+0.8642 (R
2=0.8413
***). In p-nitrophenol-glycosides, the fu
M and the K
p that were predicted from these equations were compatible with the experimental results. It was suggested from these results that the fu
M and the K
p may be predictable from the P.
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