Examinations were made on dermal absorption, physical distribution, and subacute toxicity through the skin (11 weeks) of decanohydroxamic acid, using rats. Absorption through the skin was found to give a definite blood level 1 hour after the application and comparatively large amount was distributed in the kidney and spleen 6 hours after the application, but only a small amount in the lung and heart.
Subacute toxicity of decanohydroxamic acid by skin application in rabbits (11 weeks) was examined but no marked difference from the control was observed in the growth (weight change), death rate, incidence of disease, effect on blood (erythrocytes, leucocytes, hemoglobin, reticulocytes, platelets, and blood picture), renal functions (urinary pH, prote inuria, glycosuria), liver functions (urobilinogen, bilirubin), macroscopic observations on internal organs, weight of organs and their weight ratio, and pathohistological observations (heart, liver, adrenal, kidney, lung, spleen, bone marrow, testis or ovary, skin, and thyroid), indicating that the compound has no subacute toxicity by skin application.
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