The epidemilogical surveys using purified tuberculin protein were carried out in Tohoku district of Japan. The subjects of the survey were 4163 healthy persons in Self-Defence Force and 242 inpatientss of the Fukushima Sanatorium. The type-specific reaction of purified tuberculin protein prepared from several strains (Gamou, Ishii, Miike, P16) of unclassified Mycobacteria and human tubercle bacillus (H37 Rv) observed on the populations of normal healthy persons and of the inpatints of the sanatorium. 0.15g of one purified tuberculin protein prepared from unclassified mycobacteria was used as antigen for intracutaneously on the flexion surface of a forearm. The same amount of purified protein prepared from tubercle bacillus was injected on the other forearm as the control. The number of individuals who showed stronger reaction for unclassified mycobacteria than human tubercle bacillus was found to be not so large. The rate of positive reaction was observed to vary not only with reference to the type of bacteria, but also with reference to the native prefecture of the healthy persons. From these facts, the existence of the specificity of unclassified mycobacteria strain was suggested in spite of uncertainty concerning the possibility of cross-reaction between unclassified mycobacteria and human tubercle bacillus. The positive rate on the inpatients was lower than that on the healthy persons except Miike. But the positive reaction for unclassified mycobacteria in inpatients suggested that among patients diagnosed as tuberculosis were included those with unclassified mycobacteria.
The present writer will report the results of a follow-up study of the development of new-born babies during the first twelve months after birth made with the object of examining the relationships between the abnormality at the time of pregnancy, perinatal period, or nursling period and the children's physical development . (1) The average weight of the babies treated exceeded, at the time of their birth, the national mean value announced by the Welfare Ministry in 1960, and also in every subsequent follow-up study made in the fourth, eighth, and twelfth month, it showed 7 to 11% more than the same mean value . (2) The average stature at the time of birth showed 0.4% less than the above mean value, but it amounted to 2.7% more in the fourth month, to 2.1% more in the eighth month, and to 2.7% more in the twelfth month. (3) The weight at the time of birth and that in the twelfth month are observed to have a correlation with 0.1 % level of significance, while the stature at the time of birth and that in the twelfth month with loo level of significance . (4) At the time of birth 13 girls out of 48 weighed less than the mean value' but the number of these undergrown girls decreased to 5 in the twelfth month. The number of the boys who weighed less than the mean value at the time of birth also decreased from 9 to only 2. The facts show that most of the babies have been growing prosperously. (5) As for stature 15 girls stood less than the mean value at the time of birth, but the number decreased to 5 in the twelfth month, while 7 boys stood less at the time of birth and only 4 did in the twelfth month. (6) Those cases which descended in the stature proportion to the mean value during the twelve months numbered only 5, and the others showed either ascent or equivalence. (7) In the relationship between the mother's abnormality and the child's development, it has been found that toxemia of pregnancy, anemia, delivery by means of absorption, Caesarian operation, premature rupture, etc. have nothing to do with the physical development of children. (8) In the relationship between children's abnormality and their development it has been found that their asphyxia, icterus, cyanosis, the irregular breathing, the crying habit, the physiological decrease of weight, etc. have nothing to do with the regular development of their weight and stature. In short, it may be pointed out, contrary to the popular view, that no significant relationship can be observed between the abnormality in pregnancy, perinatal period, or babyhood and the development of the stature and weight of new-born children.