We surveyed 172 femeles in a mountain village named Yachiho-Mura in Nagano-Ken. Prof. TUBAKI' Kozi' the Head of our Department found that in mountain villages the females live shorter than the males . He supposes the main reason of this fact is chronic accumulation of fatigue. From this idea we tested village women by interview method. The survey was done on the acute fatigue compleints (physical, mental and neurosensory complaints), Farmers Symptom-Complex or Nofusho and on the degree of aging process by the method of Japan Industrical Research Committee on Fatigue." Scores obtained are shown in Table 5 and Fig. 2. As shown in them females in hilly parts and intermediate parts got somewhat higher marks than the flat parts, that is they feel more fatigue than the flat part females. This means that they do daily works heavier than the lower plain part women.
The factor of the cerebrovascular death was studied from the findings of blood pressures, ocular fundi, electrocardiograms and of proteinuria, of a four year follow-up observation on 2679 hypertensive persons of farm and fishing villages in miyagi prefecture. The results follow: 1) Mortality from cerebrovascular disease was higher at the group with the items of severe ocular findings, of systolic blood pressure 180 mmHg and over, of abnormal ST. T waves in ECG and of proteinuria, compared with the group with less severe findings. 2) The risk becomes much greater when those items of high blood pressure, severer ocular findings than K.W.IIa, ECG findings of abnormal ST.T and of proteinuria accumulate each other. 3) Findings of proteinuria seems to be one of the important risk factors. 4) The risk of a group with the items of systolic pressure 180 mmHg and over, abnormal ST.T waves and proteinuria, was 18.3%. This risk seemed to show no significant difference from that of 12.4% at a group with the items of systolic pressure 180 mmHg and over, abnormal ST.T waves and severer ocular findings than K.W.IIa.
That Egonoir is not a foodstuff universally eaten throughout Japan, but one locally eaten by a limited number of people was revealed by my investigation in Nagano Prefecture, published in my first report. The present report deals with my investigation in 1966 concerning the eating of Egonori among 11.440 junion high school students in Gumma, Fukushima and Yamagata Prefectures. According to this investigation, the seaweed is seldom eaten is Gumma Prefecture, while the rate of its being eaten in Fukushima Prefecture is only 6%. In Yamagata Prefecture the rate is 65%. It has also been discovered how much the food is relished, in what season of the year it is most liked, and in what form and conditions people get it.
In the prevention of viral diseases, vaccine plays a very important role as prophylactic means for susceptible hosts. In the case of influenza, where the etiological virus has been undergoing changes in antigenic structure, it is necessary to select a viral strain most suitable as antigen for vaccine or to be careful about the use of such strain. The author studied this subject on the basis of the antibody retained by hosts and the development and behavior of such antibody. The present investigation was carried out the inhabitants of a rural area where it was presumed that an epidemic of influenza would occur only to disappear where it was presumed that an epidemic of influenza would occur only to disappear within a short period of time, withrout causing any marked confusion. These inhabitants were inoculated with influenza adjuvant vaccine. Francis's Original Sin Theory on antigen was applied. Sero-epidemiological examination was conducted on the state of maintenance of antibody prior to inoculation and the development and behavior of antibody three months after inoculation. The following results were obtained from this examination. The vaccine used was a polyvalent one composed of four strains of type A, including the classical Aswine/31 strain, and three strains of type B. All these strains, except the Aswine/31 strain which was of porcine origin, were proved to be available as vaccine with satisfaction, giving rise to sufficient antibody. It was assumed that the Aswine/31 strain might indicate the limit of use a strain of animal origin. This strain is considered to have the same antigenic structure as the etiological virus of Spanise influenza and gives rise to the phenomenon of Davenport in some age group of inhabitants inoculated. There was nothing specific observed in the behavior of f he viral sf rains of A0 and A1 Fypes used. These strains showed gradual morphologicalchanges in the course of antigenic variation. Such specificity as considered to produce any antigenic variant type was not exhibited either in the behavior of the strains Btype. The Taiwan strain, which had had no connection with any outbreak of influenza in Japan, presented a strong behavior when inoculated into the inhabitants of such age groups as exceeding forty years. Accordingly, this strain seems to have revealed a specificity of changes in antigenic structure among the strains of B type used. From the results mentioned above, it is concluded that in f he control of influenza, vaccine should be prepared from the viral strain which was prevalent in some past outbreak and epidemic in every age group of people and which has undergone variation in antigenic structure. In this case, it is necessary to select an antigen suitable for each age group of people. It is also possible to predict the effect of antibody production from a sero-epidemiological point of view.