Some exogenous chemicals such as PCB, tributyltin compounds (TBT), and diethylstilbestrol (DES) are reported to disrupt the action of the sex hormones, thus resulting in unexpected biological effects. The manufacture and use of these chemicals have strictly been restricted in Japan. Bisphenol A and nonylphenol are suspected to be endocrine disrupter. However the both phenol chemicals are degradable in the environment and far less toxic than PCB, TBT and DES.
Environmental pollution with chemical substances are reported to be getting serious every year by mass media. However it peaked around 1970 and has been improved evidently since that. This report deals with the overall evaluation of the endocrine issue in Japan.
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