巻号一覧
71 巻, 6 号
選択された号の論文の10件中1～10を表示しています
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巻頭言
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萩原 久大2013 年 71 巻 6 号 p. 575
発行日: 2013/06/01
公開日: 2013/07/19
ジャーナル オープンアクセスPDF形式でダウンロード (796K)
総説および総合論文
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山口 潤一郎, 武藤 慶, 天池 一真, 山本 拓矢, 伊丹 健一郎2013 年 71 巻 6 号 p. 576-587
発行日: 2013/06/01
公開日: 2013/07/19
ジャーナル 認証ありNickel-catalyzed cross-coupling reactions have recently been receiving significant attention from the synthetic community as a way to construct carbon-carbon or carbon-heteroatom bonds, because nickel catalysts are less expensive and less toxic than palladium catalysts.
We herein describe our recent developments in nickel-catalyzed biaryl coupling methodology, along with mechanistic studies and applications to the synthesis of natural products and pharmaceuticals. In particular, we focus on nickel-catalyzed direct coupling reactions in which “unreactive” bonds such as C-H, C-O, and C-C bonds are converted into biaryl moieties.抄録全体を表示PDF形式でダウンロード (2571K) -
河内 卓彌, 垣内 史敏2013 年 71 巻 6 号 p. 588-600
発行日: 2013/06/01
公開日: 2013/07/19
ジャーナル 認証ありDirect functionalization of unreactive bonds catalyzed by transition metal complexes has become a powerful tool in organic synthesis and has been studied extensively by many researchers. Our research group has been exploring regioselective functionalization via chelation-assisted cleavage of unreactive bonds by transition metal catalysts. Here we describe our recent efforts toward development of efficient methods for construction of π-conjugated systems by catalytic substitution via chelation-assisted cleavage of unreactive aromatic carbon-hydrogen and -heteroatom bonds. Ruthenium catalysts were employed to cleave aromatic carbon-hydrogen, carbon-oxygen, carbon-nitrogen, and carbon-fluorine bonds (aromatic carbon bonds) at ortho positions of directing groups and to introduce aryl, alkenyl, and carbonyl groups onto the aromatic rings. Application of these methods for short syntheses of substituted fused aromatic compounds such as twisted anthracenes, pentacenes, dibenzo[a,h]anthracenes, and picenes is also described.抄録全体を表示PDF形式でダウンロード (2050K) -
三木 康嗣, 井上 達広, 大江 浩一2013 年 71 巻 6 号 p. 601-615
発行日: 2013/06/01
公開日: 2013/07/19
ジャーナル 認証ありThis review focuses on the development of metathesis polymerization-based polymers for medical application including therapeutic and diagnostic agents. The feature of metathesis polymerization, ring-opening metathesis polymerization (ROMP) and acyclic diene metathesis (ADMET) polymerization, is briefly outlined. The modification methods to synthesize highly functionalized polymers as well as the functional group tolerance under the polymerization conditions are described. The delivery of antitumor drugs, genes, and contrast agents utilizing polymeric nanoparticles is discussed. Recent application of metathesis polymerization-based ionic polymers to antimicrobial materials, cell-penetrating materials, antifouling materials, and signal transducers is also summarized.抄録全体を表示PDF形式でダウンロード (3156K) -
眞鍋 史乃, 佐藤 寛子2013 年 71 巻 6 号 p. 616-624
発行日: 2013/06/01
公開日: 2013/07/19
ジャーナル 認証あり1,2-cis amino glycosides are often found in biologically active oligosaccharides. For the stereoselective formation of 1,2-cis aminoglycosides, glycosyl donors with 2,3-trans carbamate group were developed. The first synthesis of anti-Helicobacter pylori oligosaccharide was achieved by using the novel glycosyl donor in an effective manner. Furthermore, the pyranosides with 2,3-trans carbamate groups were found to undergo endocyclic cleavage reactions, which are rarely found in pyranosides. The endocyclic cleavage reaction was confirmed both from experimental and computational approaches.
As an additional example of cooperative work of experimental and computational chemistry, understanding of the solvent effect in glycosylation reactions was also described.抄録全体を表示PDF形式でダウンロード (1816K) -
石川 稔, 橋本 祐一2013 年 71 巻 6 号 p. 625-636
発行日: 2013/06/01
公開日: 2013/07/19
ジャーナル 認証ありAqueous solubility is essential for drug candidates, and improvement of the aqueous solubility of bioactive compounds is a major issue for medicinal chemists. The strategy of introducing hydrophilic group(s) into molecules is generally used for this purpose, but is not universally effective. We proposed an alternative strategy for improving aqueous solubility, that is, modification of bicyclic molecules in ways that would disrupt molecular planarity by increasing the dihedral angle or that would disrupt the molecular symmetry. Such planarity-or symmetry-disruption has the effect of decreasing the efficiency of crystal packing, which in turn results in an increase of aqueous solubility. Improvement of aqueous solubility by 350-fold was achieved in one example. Furthermore, to clarify the mechanisms of improvement of aqueous solubility, we examined the changes in physicochemical properties of the compounds.抄録全体を表示PDF形式でダウンロード (2811K)
Review de Debut
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秋元 隆史2013 年 71 巻 6 号 p. 637-638
発行日: 2013/06/01
公開日: 2013/07/19
ジャーナル オープンアクセスAplyviolene (1) is a diterpene isolated from marine sponge, it has characteristic structures of cis-perhydroazulene and 6-acetoxy-2,7-dioxabicyclo[3.2.1]-octan-3-one moieties. One of the synthetic challenges of 1 is a stereoselective construction of continuous carbon centers at C8 (quaternary carbon) and C14. In this mini review, a total synthesis of aplyviolene by Overman was discussed focusing on the control of those stereocenters by using prochiral nucleophiles of 6 or 10 with electrophiles.抄録全体を表示PDF形式でダウンロード (1153K)
ラウンジ
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秋山 隆彦, 由良 毅2013 年 71 巻 6 号 p. 639-641
発行日: 2013/06/01
公開日: 2013/07/19
ジャーナル 認証ありPDF形式でダウンロード (2751K)
十字路
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三木 康嗣, 大江 浩一, 眞鍋 史乃, 石川 稔2013 年 71 巻 6 号 p. 643
発行日: 2013/06/01
公開日: 2013/07/19
ジャーナル オープンアクセスPDF形式でダウンロード (731K)
Let’s Challenge
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2013 年 71 巻 6 号 p. 644-646
発行日: 2013/06/01
公開日: 2013/07/19
ジャーナル 認証あり
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