巻号一覧
72 巻, 4 号
選択された号の論文の13件中1～13を表示しています
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巻頭言
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包 明2014 年 72 巻 4 号 p. 359
発行日: 2014/04/01
公開日: 2014/05/16
ジャーナル オープンアクセスPDF形式でダウンロード (808K)
総説および総合論文
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橋本 誠, 村井 勇太2014 年 72 巻 4 号 p. 360-369
発行日: 2014/04/01
公開日: 2014/05/16
ジャーナル 認証ありPhotoaffinity labeling is one of the favorite methods for chemical biology. The first step in this method is the construction of photophores and their modification to the associated high affinity target ligand. α-Amino acids have biological activities themselves and are fundamental component of peptides and protein. The photoreactive aromatic α-amino acids are useful for investigation of biological phenomenon. Although synthesis of photoreactive phenylalanine analogues has already been reported, there have been few reports of the synthesis of photoreactive tryptophan and side-chain elongated phenylalanine. We report here the effective photoreactive tryptophan and side-chain elongated phenylalanine derivatives. Furthermore, we report the mild and controllable hydrogen-deuterium exchange for aromatic hydrogen with trifluoromethanesulfonic acid-d during the course of the synthesis of side-chain elongated phenylalanine. These hydrogen-deuterium exchange properties for these aromatic α-amino acids are identical to those of the peptides. With this method the exchange proceeds significantly faster than previously described methods. Detail analysis of the exchange revealed that the method was controllable by temperature-, time-, and dose- dependent manner.抄録全体を表示PDF形式でダウンロード (2206K) -
武井 史恵, 中谷 和彦2014 年 72 巻 4 号 p. 370-381
発行日: 2014/04/01
公開日: 2014/05/16
ジャーナル 認証ありDNA is a typical chemical compound consisted of carbon, hydrogen, oxygen, nitrogen, and phosphorus atoms. But the marked difference of DNA from other chemicals and biopolymers is that DNA can be amplified by polymerase. No matter how small amount of DNA can be in principle amplified. This has been achieved by polymerase chain reaction (PCR). PCR needs polymerase, templates, and primers. In this review, we focused our attention on the chemical probing of PCR primers. Because PCR is a basic technology in biology research fields, we sometime uses chemically labeled primers without any consciousness on its chemistry behind. We would like to emphasize that chemically labeled primers contained a lot of chemistry ideas and much study is still necessary for advancing the PCR for SNP typing and genetic diagnosis, and other fields. Here, we focus the affinity-capture primers and signaling primers. The former is used for purification, isolation and manipulation of PCR product by high specificity and affinity to the cognate molecules by the molecular-molecular interaction. The latter has fluorescent molecule or fluorescence binding sites in hairpin primers, and the fluorescence emitted from the primer is used for a PCR monitoring system.抄録全体を表示PDF形式でダウンロード (3141K) -
岡本 専太郎2014 年 72 巻 4 号 p. 382-392
発行日: 2014/04/01
公開日: 2014/05/16
ジャーナル 認証ありIn the presence of Me3SiCl or MgCl2, Ti(OR)4 was reduced by Mg powder in THF to gradually generate a specific low-valent titanium species, which mediated or catalyzed several synthetic reactions such as C-O bond-cleavage of allyl and propargyl ethers and esters, intra- and intermolecular cyclotrimerization of alkynes, reduction of epoxides and oxetanes via homolytic ring-opening, McMurry coupling reaction of aryl aldehydes, imino-pinacol coupling and reductive N-S or O-S bond-cleavage of sulfonamides or sulfonyl esters.抄録全体を表示PDF形式でダウンロード (2000K) -
佐藤 真, 山高 博2014 年 72 巻 4 号 p. 393-404
発行日: 2014/04/01
公開日: 2014/05/16
ジャーナル 認証ありRecently, dynamics effect is claimed to be a very important factor in determining the reaction mechanisms. In molecular dynamics (MD) simulations of the Beckmann rearrangement/fragmentation, E2/E1cb, and carbonyl addition/substitution, the dynamic path bifurcation was observed, where two reaction products were obtained dynamically depending on the shape of the potential energy surface after passing through the corresponding transition state (TS). This is a very significant problem because the strategies of organic syntheses are generally based on the transition state theory, intending to stabilize/destabilize the TS of a desired/undesired reaction relative to the other ones. As applications of the MD simulations in solution chemistry, fundamental organic reactions (SN2 reaction of the methyl diazonium ion, hydration and amination of formaldehyde) in water solution were examined by using the fragment molecular orbital method with MD, FMO-MD. These simulations revealed that the reactions in solution are more complicated and various than one would expect.抄録全体を表示PDF形式でダウンロード (3534K) -
近藤 和弘2014 年 72 巻 4 号 p. 405-417
発行日: 2014/04/01
公開日: 2014/05/16
ジャーナル 認証ありIn this review, our studies in relation to development of catalytic asymmetric reactions based on conformational control, are embodied, which are divided by content into four sections as follows: (1) asymmetric Grignard cross-coupling reaction with Pd and a N-Ar axially chiral mimetic-type ligand catalyst; (2) asymmetric intramolecular α-arylation of N-(2-bromophenyl)-2-arylpropanamides with Pd and a chiral mimetic-type N-heterocyclic carbene ligand catalyst; (3) asymmetric arylation of aromatic aldehydes using phenylboronic acid with Rh and a hemilabile phosphorus ligand based on conformational control; (4) asymmetric arylation of conformatinally fixed aromatic aldehydes bearing an ortho-Me2PhSi group, using potassium 1-aryl-4-methyl-2,6,7-trioxa-1-boranuidabicylo[2.2.2]octanes as aryl sources with Ni and a (R,R)-Et-duphos ligand catalyst.抄録全体を表示PDF形式でダウンロード (2157K) -
田山 英治2014 年 72 巻 4 号 p. 418-428
発行日: 2014/04/01
公開日: 2014/05/16
ジャーナル 認証ありThe Sommelet-Hauser rearrangement of N-benzylic ammonium ylides generated from tetraalkylammonium salts is an interesting and useful transformation in organic synthesis that can provide easy access to ortho-substituted aromatic compounds. The base-induced rearrangement of an N-chiral-N-benzylic proline-derived ammonium salt or N-benzylic amino acid (−)-8-phenylmenthol ester-derived ammonium salts is shown to proceed in excellent yields with perfect levels of diastereoselectivity without any detectable amount of the [1,2]Stevens rearrangement product. A solution of potassium tert-butoxide in THF was shown to remarkably enhance the base-induced Sommelet-Hauser rearrangement of N-benzylic amino acid-derived ammonium salts. The reaction proceeds under mild conditions with minimal competition from the [1,2]Stevens rearrangement. These methods provide efficient access to α-aryl-α-amino acid, α-aryl-β-amino acid, and α-arylpipecolinic acid derivatives.抄録全体を表示PDF形式でダウンロード (1751K)
Review de Debut
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杉江 敦司2014 年 72 巻 4 号 p. 429-430
発行日: 2014/04/01
公開日: 2014/05/16
ジャーナル オープンアクセスGold nanoparticle whose surface is protected by adsorption of thiols attracts considerable attention as advanced materials. Organic-bond forming reaction on the surface of thiol-capped gold nanoparticle would be effective protocol for introduction of functionality onto gold nanoparticle. This review highlights selected examples of recent advance in organic-reaction inspired surface modification of gold nanoparticle.抄録全体を表示PDF形式でダウンロード (983K) -
小池 隆司2014 年 72 巻 4 号 p. 431-432
発行日: 2014/04/01
公開日: 2014/05/16
ジャーナル オープンアクセスHigh-valent arylcopper(III) intermediates have long been proposed to have a key role in copper-catalyzed arylation. Recently, stoichiometric reactions of some isolable arylcopper(III) complexes prove their involvement in carbon-heteroatom bond formation. In addition, highly effective arylation reactions catalyzed by putative arylcopper(III) species were reported more recently. In this mini-review, I describe recent advances in high-valent organocopper chemistry.抄録全体を表示PDF形式でダウンロード (953K) -
佐々木 郁雄2014 年 72 巻 4 号 p. 433-434
発行日: 2014/04/01
公開日: 2014/05/16
ジャーナル オープンアクセス(+)-Scholarisine A(1), a akuammiline alkaloid that was first isolated in 2008 from the leaves of Alstonia scholaris, comprises an unprecedented scaffold containing a bridged lactone inscribed in a cagelike skeleton. Structural and biological features of 1 have attracted much attention from synthetic chemists. In this review, total synthesis of 1 reported by Smith’s group and Snyder’s group are described.抄録全体を表示PDF形式でダウンロード (1108K)
ラウンジ
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鳶巣 守2014 年 72 巻 4 号 p. 435-446
発行日: 2014/04/01
公開日: 2014/05/16
ジャーナル 認証ありPDF形式でダウンロード (2188K)
十字路
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武井 史恵, 中谷 和彦, 佐藤 真, 山高 博2014 年 72 巻 4 号 p. 447
発行日: 2014/04/01
公開日: 2014/05/16
ジャーナル オープンアクセスPDF形式でダウンロード (772K)
Let’s Challenge!
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2014 年 72 巻 4 号 p. 448-451
発行日: 2014/04/01
公開日: 2014/05/16
ジャーナル 認証あり
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