The statistical observation on the result of therapeutic treatment of paranasal sinus carcinoma was reported.
The patients were 109 cases in our institution during the past 16 years.
In operated 73 cases, one year survival rate was 57.3%, 2 years 35.3%, 3 years 27.0%, 5 years 25.0%, respectively.
The best result was obtained by Denker's method, while the group in which preoperative irradiation was applied, had unfavorable prognosis against our expectation.
To attain better results of therapeutic treatment on the paranasal cancer, preoperative arterial infusion of antitumor agents has been tried in 5 cases since 2 years.
The histological examination and comparative study of the extirpated tumor have indicated that all three therapeutic methods (preoperative infusion 5 cases, preoperative irradiation 3, combind method 3) were more or less effective for transmutation of cancerous cell.
However, I have noted that arterial infusion was the most efficacious at the histological view point. But the combinded method of preoperative radiation and arterial infusion was not so effective as expected.
Although I have thought that the preoperative arterial infusion is one of the effective means considering from the point of view of histology and it simplifies the radical operation, there remains much to be studied to refer to its final results.

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Twenty-nine cases of malignant tumor of the head and neck, that is, 19 cases of the maxillary carcinoma, 3 cases of the lingual carcinoma, 2 cases of the tonsillar carcinoma, 2 cases of the epipharyngeal carcinoma, 1 case of the maxillary sarcoma, 1 case of the tonsillar carcinoma and 1 case of the soft palatal carcinoma were treated with cancer chemotherapeutic agent which infused into the external carotid artery (in one case via the superior thyroid artery and in one case retrogradely via the superficial temporal artery) as a supplementary means of radical operation or radiotherapy over the past two years and five months.
The medicines administrated were Mytomycin C, Endoxan, and Toyomycin, and their administration methods were as follows;
(1) To dissolve antitumor agent in 20cc. of 5% glucose solution and infuse it twice a day, that is, once in the morning, and once in the evening.
(2) To dissolve antitumor agent in 500cc. of physiological salt solution with 2,500u. of heparin, and infuse it continuously for about five hours. The period of administration was from five to forty-six days.
In the case of the carcinoma of the maxillary sinus, I opened operatively the maxillary sinus during the administration of the antitumor agent, and observed the macroscopic change of the tumor, and found that a week after the arterial infusion, the tumor apparently began to fall into necrosis from lateral side of the maxillary sinus, and when the arterial infusion ended up, the tumor was reduced cicatricially in the median posterior part of the maxillary sinus. Therefore, radical operation was done easily and in a small part.
In the case of the carcinoma of the maxillary sinus, if operative therapy was not done, arterial infusion chemotherapy, even when done together with radiotherapy, could not cure the disease radically.
The results of 22 cases treated with arterial infusion chemotherapy were as follows;
1. One out of 4 cases has been showed complete remission more than two years.
2. Five out of 11 cases have been showed remission more than a year.
3. Three cases have been passed more than a year after the treatment, and at present, they are under treatmeut because of their recurrences.
4. Four out of 7 cases have been no evidence of disease within a year.
5. One case recurred within a year and is now under treatment.
The most serions complication was the leucopenia caused by bone marrow depression, and as it was found in 14 out of 29 cases, it must be taken the greatest care of. Decrease of appetite was also found in 18 cases, and it, together with leucopenia, was the indication to stop arterial infusion. Occasionally, alopecia, local stomatitis, necrosis of local tissue, exanthema on the limbs, choking of catheter, and prolapse were recognized.

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The purpose of this investigation is to decide accurately the anatomical dimensional structure of maculae staticae and their position in the cranium of mammals. The subjects used here consisted of men, rabbits, cats, goats and dogs.
Models of the maculae of these mammals were prepared according to the modified reconstructing method reported by J. Corvera, C. S. Hallpike and E. H. J. Schuster.
1. The anatomical dimensional structure of maculae staticae:
The utricular macula, consisting of the chief, anterior and medial portions, was elliptical in shape,(1.5-3.0mm in longitudinal diameter and 1.0-1.9mm in horizontal diameter). The saccular macula, consisting of the chief, anterior and dorsal portions, was longer and more slender than the utricular (2.0-3.6mm in longitudinal diameter and 0.3-1.1mm in vertical diameter). Each portion of the maculae had a curved surface and no radical difference in the anatomical dimensional structure was recognized between the species.
2. The position of Maculae staticae:
Only a slight difference between the species was found in the position of the saccular macula but a clear difference was recognized in that of the utricular macula. The utricular macula lay nearly horizontally but the frontal part of its chief portion had a tendency to face upward to the inside of the skull. In case of dogs, however, it had tendency to face downward the horizontal skull plane. The saccular macula stood almost vertical, but the frontal part of its chief portion had a tendency to face outside the sagital plane, the base had a tendency to face downward to the out side of the skull.
3. The mutual relation between the utricular and saccular maculae:
The saccular macula lay 0.1mm behind, 0.9mm below, and 0.8mm inside the utricular macula. There was a pair of portions corresponding to one another between the utricular and saccular maculae. Each corresponding pair was nearly parallel. The chief portion of the utricular macula corresponded to the dorsal portion of the saccular macula; the anterior portion to the anterior portion, and the medial portion to the chief portion, respectively.
From the functional viewpoint, the utricular and saccular maculae apparently occupied a quadrant of the whole surface of an ovoid body.

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