Although the nonspecific hyposensitization for nasal allergy has been clinically applied in the otorhinolaryngological field, the mechanism and the indication of this therapy has been not well known until the present time. In this present study, in order to clarify the indication of nonspecific hyposensitization therapy, clinical efficacy of this therapy for nasal allergy and laboratory findings of the patients with nasal allergy were retrospectively studied. The results obtained from this study were as follows;
(1) In the group of the adult patients treated with the combinated administration of Histaglobin (HG) 3-vials and Neurotropin (NSP) 1-Amp. per a week, the clinical efficacy rate was 76.2% (Adult group). Furthermore, in the group of the infant patients treated with HG 2-vials per a week, the clinical efficacy rate was 88.9% (Infant group).
(2) In the adult group, the patients whose serum IgE level were below 999 IU/ml in the pretreatment state showed some improved symptoms and clinical findings in comparison to those with serum IgE level above 1000 IU/ml. In the infant group, the patients with the score below 2 of skin reaction test showed some improved conditions in comparison to those with the score above 3.
(3) In the adult group, it was observed that the score of eosinophils in the nasal secretion significantly decreased in the considerably improved patients in the posttreatment state. In the infant group, the statistically significant increase of histaminopexic action, was noted in the considerably improved patients in the posttreatment state, also the significant increase of the score of the skin reaction test was noted in the same population.
From the above mentioned results, it was clarified that there were some differences between the clinical backgrounds of adults and infants with nasal allergy in reference with the clinical efficacy rate on the nonspecific hyposensitization therapy. For the infant patients, HG 2-vials therapy was considerably available to hyposensitize them nonspecifically. On the other hand, the combinated therapy of HG 3-vials and NSP 1-Amp. for the adult patients did not show high efficacy rate in comparison with the HG 2-vials therapy for the infants. Furthermore, it was suggested that a large amount of HG and NSP should be medicated in the adult patients with nasal allergy as the drugs of the nonspecific hyposensitization therapy.

View full abstract

HIRANO (1975, 1977) has proposed the concept that the vocal fold has a layer structure. KURITA (1980) reported differences in the layer structure along the longitudinal axis of the vocal fold. The purpose of this paper is to examine whether this layer structure influences vocal fold vibration. The vocal folds of a normal male adult were photographed with an ultra-high speed camera during phonation and one vibratory cycle was selected for frameby-frame analysis. Since we were not able to photograph the entire vocal folds in one film, the anterior and the posterior parts of the vocal folds were photographed separately. The results are summarized as follows:
I Anterior part
1) Vibration was not observed in two-thirds of the anterior macula flava.
2) The opening of the glottis began from the rear. Maximum amplitude was observed at a site 4.5 millimeters from the anterior commissure.
3) The closed phase was the longest at the posterior site of the anterior macula flava. The opening and closing phases were the shortest at the posterior site of the anterior macula flava.
II Posterior part
1) Vibration was observed at the anterior tip of the posterior macula flava.
2) The glottis began to open at the rear. Maximum amplitude was recognized at a site 8.5 millimeters from the anterior commissure.
3) The closed phase was the longest at a site 4.5 millimeters from the anterior com-missure. The opening and closing phases were the shortest at a site 4.5 millimeters from the anterior commissure.

View full abstract

The purposes of this study are to provide a standardized gross anatomical measure concerning the cricopharyngeus muscle and to provide a standardized diameter of the cricopharyngeus muscle fibers. For the former, excized specimens from 40 adults (20 males and 20 females) were used whereas specimens from 14 adults (10 males and 4 females) were investigated for the latter. The results were as follows:
1. The mean width of the posterolateral portion of the cricopharyngeus muscle was 11.5mm for male and 10.6mm for female.
2. The mean width of the cricopharyngeus muscle including both the oblique and the transverse portion was 26.8mm for male and 22.1mm for female, when measured on the posterior midline. The mean value for the transverse portion was 13.9mm for male and 11.7mm for female.
3. In all the specimens, the recurrent laryngeal nerve entered the larynx posteriorly to the inferior horn of the thyroid cartilage except in one side. The mean distance between the nerve and the extension of the corner was 1.35mm for male and 0.75mm for female.
4. The location where the recurrent nerve enters the larynx was observed anterior to the anterior edge of the esophagus. The mean distance between the esophagus and the nerve was 2.24mm for male and 1.98mm for female.
5. The mean diameter of the cricopharyngeus muscle fibers was 38.9 pm for male and 32.6μm for female.

View full abstract

Since October 1976, I clinically applied the principal regimens of a multiple combination chemotherapy heretofore reported, and studied their efficacies. While on the other hand, fundamental studies of cancer chemotherapy based on cell kinetics using nude mice and cytofluorograph had been performed. And from the results of the clinical application of the known regimens of multiple drug combination chemotherapy and those of the fundamental studies, two clinical protocols were developed.
One regimen is a M-phase synchronized combination chemotherapy, using Vincristine, Methotrexate, Bleomycin and Mitomycin-C, and the other is S-phase synchronized combination chemotherapy, using Hydroxyurea, Adriamycin and Bleomycin. Since May 1979, 51 patients with malignant tumors of the head and neck regions were treated with these two regimens. Positive responses (more than 50 % tumor regression) were obtained in 74% (29/39) of the cases treated by regimen I, and in 43% (3/7) of the cases by regimen H.
The lassitude and febrile responses provided the main problems during the treatment but they were only transient. Late complications were found in the bone marrow suppression. One patient in the advanced stages with a poor prognosis was treated with regimen I which had on episode of sepsis which ended in death.
These results illustrate a potential for combination chemotherapy for head and neck cancer.

View full abstract

Forty-six patients with Bell's palsy and 19 with Ramsay Hunt (RH) syndrome were studied. They were followed their course to complete recovery or for 6 months. They were observed as to the degree of paralysis and were tested repeatedly with Schirmer's test, the stapedial reflex test, the gustometry, the salivation test and the nerve excitability test (NET). The following results were obtained.
1) There was no relationship between the degree of paralysis and prognosis in either Bell's palsy or RH syndrome.
2) The affected regions were inferred in 70% of the cases of both Bell's palsy and RH syndrome. The affected areas were found from below the geniculate ganglion to above the chorda tympani nerve in Bell's palsy and centered mainly in the geniculated ganglion in RH syndrome.
3) A fourfold increase in the titer of varicella zoster virus was found in one out of 19 Bell's palsy patients and in four out of 12 cases of RH syndrome.
4) The results of the stapedial reflex test conducted at the fourth to fifth weeks after onset showed a correlation with the prognosis in Bell's palsy, that is, the prognosis depended on the presence or absence of abnormality. It may be said that the patients who visited a doctor within one month after onset and showed a normal response to the stapedial reflex test were able to make a complete recovery.
5) The results of the gustometry and NET conducted at the fourth to fifth weeks after onset showed a correlation with the prognosis in RH syndrome, that is, the prognosis depended on the presence or absence of abnormality. Patients who showed normal response to the gustometry at the time of the initial consultation within one month after onset were able to make a complete recovery.

View full abstract