To determine whether steroids are necessary during the initial treatment of acute low-tone sensorineural hearing loss (ALHL), a multicenter study was carried out in patients with ALHL who were examined at seven ENT clinics in Kumamoto prefecture. The patients were randomly divided into one group that orally received an adenosine triphosphate-disodium preparation (ATP) alone (group A, n=58) or steroids combined with ATP (group B, n=62) The background factors (age, gender, time between onset of symptoms and start of treatment, and the severity of hearing loss at low-tone frequencies) were not significantly different between the two groups. On evaluation by audiography at 1 week after treatment, the cure rate was 59% and 45% in groups A and B, respectively. The respective improvement and no-change rates were, respectively, 22% and 19% in group A and 40% and 16% in group B. After 4 weeks, the respective cure, improvement, and no-change rates were 76%, 15%, and 9% in group A, and 74%, 21%, and 5% in group B. Regarding these treatment outcomes, no significant differences were thus observed between the two groups. These results demonstrate that steroid administration is therefore not necessary during the initial treatment of ALHL.
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