[in Japanese]

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The distribution of adrenergic fibers in the guinea pig esophagus, trachea and bronchi were fluorescence microscopically examined by modified Falck's method. In the esophagus, the fibers were seen running mainly along the blood vessels in the submucosal layer and in the endomysium of the muscle layer. There was no evidence to show direct distribution of the fibers to the muscle fibers. In the trachea and bronchi, the adrenergic fibers are supplied to the submucosal and muscle layers after passing through the annular ligament. They course longitudinally to the axis of the tubes within the muscle layer and membranous part.
The fibers reach to the terminal bronchioles. Most of the fibers are seemed to be the vasomotor of the sympathetic postganglionic fibers. The mechanism of relaxation and dilation of the tubes was briefly discussed.

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In den letzten 3 Jahren hat der Verfasser die Gelegenheit gehabt, 3 Patienten mit schwerheilbarer Ménièrescher Krankheit zu behandeln. Trotz aller Behandlungen war es dem Verfasser schwierig, diese Patienten zur Heilung zu führen.
Schließlich konnte aber der Verfasser beim 1. Fall durch die Rosensche Operation, beim 2. Fall durch mehrmalige Stellatum-Blockade(60mal)and beim 3. Fall durch die Verabreichung von Steroidhormon (Dexamethason 36.5mg) vollstandig zur Heilung bringen.
Der Verfasser hat auch auf Grund seiner obengenannten Erfahrungen ausfiihrlich die Methode der Behandlung von schwerheilbarer Menierescher Krankheit beschrieben.

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Lysozyme chloride, which was extracted from egg white was used for 20 cases of vertigo and dizziness including Ménière's disease. This therapeutic enzyme on mucous membrane was administered by mouth in daily doses of from 30mg to 60mg.
Curative effects on the attack of vertigo were observed in 13 cases(65%), while there were no improvement of cochlear dysfunction except 3 cases of tinnitus. As a side-effect, nausea appeared only 1 case developed in a 28 year old male sufferring from cervical syndrom.
By our investigations it is thought that enzyme took part in metabolic process of the inner ear, therefore it is a drug to be applied for aural vertigo generally. Though little discussion has been carried on the detailed functional mechanism or a number of clinical experiences.

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Kimotab is a proteolytic medicine which consists of Bromelain and Trypsin. It was given through mouth to 24 chronic paranasal sinusitis patients.
They consciously responded to it in 5 to 14 days. The intranasal appearance became better in 10 to 14 days. Roentgenologically the effects appeared in 10 to 20 days.
Eleven of the patients (50%) remarkably responded, nine (37.5%) medially, and the rest three(12.5%) were unresponsive. So, the patients who were responsive amounted to 87.5%.
This percentage is very high probably because Kimotab is a mixture medicine and the author selected the patients who had been suffering for a shorter period (one year on an average) and whose intranasal appearance was mild.

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The design of a sound-proofed room has laid emphasis on the protection from outside noise and the sound-damping of inside noise, while ventilation and airconditioning have not been put into so much consideration.
In Yao Municipal Hospital the author studied the temperature and humidity of the sound-proofed room under air-conditioning in summer.
The following facts were obtained:
1) The noise of the air-conditioning machine was pardonably muffled by the silencer, which did not damage sound proofing and ventilation.
2) By ventilation the air humidity was reducced to 70%.
3) In case of the sound-proofed box in the sound-proofed room, the inside temperature was reduced to 0.03 to 0.09 degree per minute by keeping the door open.

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A child, aged 5, previously with normal hearing. One month ago he suffered from mumps with involvement of both parotid glands and high fever. In the course of mumps he developed 3 days after the onset, hearing impairment in the both ears.
With administration of dexamethasone and vitamine Bi, the hearingloss became gradually normal in all tone range after a year and normal hearing was again impaired by the occurrence of epipharyngitis about three months after he had completely recovered.
Whenever the patient suffered from epipharyngitis during recovery from hearingloss, his hearing was frequently extinguished.
It is thought for the infection to invade occasionally the inner ear by way of the tube and middle ear and to lead to allergic alteration in the inner ear.
But toxic neuritis in the inner ear might be a probable pathogenesis, too.
From this result infectious neuro-allergic change on the inner ear might be present in the hearing of this case which was variable due to epipharyngitis or improved on the treatment of dexamethasone.

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Rhinology has an old history It is perhaps the oldest medical recorded and is also that branch of medicine most frequently needed by mankind. In the earliest medical writings, Galen described firstly ; Showing how the air become warmed, cooled its way into the trachea. In 1883, Goodale, 1896, Minknear Leiden, Zwaardemaker, van Dishoeck, and others offered in their nasal physiology dissertations, and have done great works on basic nasal physiology. In 1942, van Dishoeck reported the great theory ; the inspiratory resistance in a normally wide nose is not caused by the conchae but by the ostium internum. In a narrow nose, on the contrary, the resistance of the conchae plays the most important part. This thesis is very important and interesting for studies of the conductivity, pressure and flow in the nasal cavity. He asserted, the study on this must be investigated on the view of anatomy, physiology and so on. The nasal resistance is composed of several moments, according to a narrow and wide, tube, lumen, vertebrae ana tomically. From 1940, mainly in Holland, and, Keuning, Spoor, Norden and especially van Dishoeck have given hope gleaming in our serious wish, before the problem was tragedy and a dark age for our rhinologists.
Of late, 1958, M. H. Cottle reported; it is necessary to investigate on the point of basic view of the air pathways with respiratory tract function anatomically and physiologically. This study, which has been investigated in Holland, Europe, passed in to the U. S. A. In future, for the rhinologic specialist these tests are dependable and objective, for the moments, they are most important diagnostic aids and they serve as a guide for evaluating medical and surgical treatment especially by reflecting on the past, and will reach to forese and anticipate the trends of proceeding.

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A female of 20 years old came for an examination of a pin in the right lateral basal branch of bronchus which had been accidentally aspirated. Under the fluoroscopy with a roentgen-television and the general narcosis by intramuscular injection of CI 581, the direct bronchoscopy was repeated, and the foreign body was successfully removed.
The removal of opaque foreign bodies beyond bronchoscopic vision is very difficult. As the fluoroscopy by the roentgen-television has a very bright image, it is a convenient aid for removal of foreign bodies by the direct bronchoscopy.
The CI 581, an intravenous or intramuscular narcoretica, is prepared by ParkDavis Co. U. S. A. But it is not yet commercialized. The prolongation of its effective time is very easy for the direct bronchoscopy compared with gas anesthesia.
The surgical operation of the chest was for a time considered to be neccessary for our own case. However, the bronchoscopical removal with the aids described above was successfully carried out at the third trial.

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The therapy of malignant tumour is exercised by operation, radiotherapy and administration of some anti-carcinogenic agent, and two or more of these methods are applied clinically to a patient.
When leucopenia is caused by the application of radiotherapy or anti-carcinogenic agent, no more therapy can be continued, and there is no medicine either which is sufficiently effective to prevent the decrease of leucocytes. So that in order to prevent the decrease of leucocytes during the application of radiotherapy or administration of an anti-carcinogenic agent, Cepharanthin was administered by 3 to 5mg. a day per os or intramuscularly to 25 cases suffering from malignant tumour.
Leucopenia was found in only 2 of the 25 cases; one case of maxillary cancer was forced to stop radiotherapy because of the dominant decrease of leucocytes. In the other cases, leucopenia appears mainly in 2 weeks after the beginning of the therapy. These results suggest that Cepharanthin acted so as to prevent the decrease of leucocytes due to radiotherapy or anti-carcinogenic agent.

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