jibi to rinsho

Early Death of the Head and Neck Cancer Patient

Kenbun INOUYE

1984 Volume 30 Issue 2 Pages 107-114
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_107

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The Tokyo University Hospital Department of Otorhinolaryngology treated 423 first-time cases of head and neck cancer from 1974 to 1978. Forty-five of the patients died of cancer within a year of their initial visit to the tumor clinic. Early death was classified according to the pathological cause. The most frequent cause of death was squamous cell carcinoma, which developed: in the ear (2 cases out of 4 died within a year), in the nasal cavity (the single case died), and in the neck (1 of 5 died). Malignant lymphoma was the second most frequent cause of death. The period from the onset of the cancer to the initiation of treatment was less than 5 months in 31 out of the 45 early death cases. Delayed initiation of treatment after the onset of cancer did not seem to be related to early death. Development of the original focus of cancer was the direct cause of death in 25 cases. Sixteen other cases showed metastasis of cancer to remote sites. The stage of development of cancer was examined. In carcinosis, 20 out of 30 cases were at stage IV, and in malignant lymphoma, 3 cases were at stage 11, 3 cases at III and 2 cases at IV.

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A Case of Submandibular Chondrosarcoma

IZUO NISHIOKA, Yumi SASAKI, Yoshinori CHIKAMORI, Hiroshi OKAMURA, Naoa ...

1984 Volume 30 Issue 2 Pages 115-119
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_115

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The authors reported a case of submandibular chondrosarcoma, and discussed the pathology, symptoms and treatment of this rare disease after reviewing the literature. The patient was a 52-year-old woman with a painless swelling of the left preauricular lesion, of three months duration. The CT sialography clearly delineated a tumor arising at the left mandibular ramus; the tumor was removed with preservation of the facial nerve. The tumor was diagnosed as chondrosarcoma by histopathological examination. A half year later, the tumor recurred at the lower end of the ramus. Wide total removal of the tumor with hemimandibulectomy was performed and 6000 rad postoperative radiation was given. No recurrence was seen for a year postoperatively.

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Radioimmunotherapy with PS-K and SPG for Carcinoma of the Larynx

Hiroomi TAKAHASHI, Makito OKAMOTO, Kazuo YAO, Takashi MATSUBAYASHI

1984 Volume 30 Issue 2 Pages 120-125
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_120

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Eighty six patients with laryngeal carcinoma were treated with a radical course of Linac X-ray therapy. The radiotherapy was followed by surgery, only when local recurrence became evident. Thirty cases out of 86 patients were given PS-K or SPG as non-specific immunopotentiators at the same time as radiotherapy. For these 30 cases, the immunological parameters, two-year survival rate and two-year preservation rate of the larynx, were compared with those of the remaining 56 cases given irradiation alone. There were no significant differences in the parameters of the humoral factors (CH 50, serum immunglobulin) between 30 cases of radioimmunotherapy and the control group. The parameters of cellular immunity, peripheral blood lymphocyte counts and T-cell counts, decreased similarly with not only radiotherapy but also radioimmunotherapy in the six months after the beginning of the therapies. The PHA blastformation rate of the peripheral blood lymphocytes returned to the pretreatment level within five months of the beginning of the radioimmunotherapy, while in the control group it did not return within seven months. The two-year survival rates were 93% (28/30) in the group of radioimmunotherapy and 86% (48/56) in the control group. The rates of those with the larynx preserved reached 73% (22/30) and 57% (32/56) respectively.

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[in Japanese], [in Japanese], [in Japanese], [in Japanese]

1984 Volume 30 Issue 2 Pages 126-130
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_126

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A Basic Study on the Vocal Fold Vibration from the Viewpoint f the Layer System of the Vocal Fold

Tohru TSUZUKI

1984 Volume 30 Issue 2 Pages 131-152
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_131

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This study has been performed mainly in order to clarify the vibratory mode observed in the muscle layers of the vocal fold. It was also the purpose of this study to observe how the muscle layer influences on the vocal fold vibration itself during the phonation. An experimental sound was obtained by use of canine larynges. As constrasting media, lead pellets were inserted into various areas of the vocal fold, under the epithelium, inner layer, and also deep inner layer (muscle layer). For data collection, an X-ray stroboscope developed in our laboratory was driven by a trigger from a laryngostroboscope. The experimental sounds were produced while 1) all the internal laryngeal muscles were activated, 2) all the internal laryngeal muscles but the cricothyroid were activated and 3) only the cricothyroid was activated. Pellets movements were X-ray cinematographically taken and analyzed afterwards with a film motion analyzer. Regular movements were not obtained in the pellets inserted into the muscle layer in all cases. From these results mentioned, it was concluded that the muscle layer might not play an important roll as a vibratory body for producing sound while the motion of the epithelium membrane of the vocal fold must be essential for it.

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Studies on Tissue Distribution of ¹⁴C-DL-8280 in Otorhinolaryngological Field

Kanetaka MURAI, Shunkichi BABA, Haruo TACHIZAWA, Mitsuyoshi TSUMURA

1984 Volume 30 Issue 2 Pages 153-156
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_153

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The distribution of antimicrobial agents in infected tissue would be essential for their application to the sites of infection. Taking accounts of the viewpoint, we had reported the distribution of 2 nalidixic acid analogs in the tissues which are related to otorhinolaryngology. We investigated here the distribution of nalidixic acid analog DL-8280. This agent was supplied by Daiichi Seiyaku Co., Ltd. Autoradiography was performed 30 minutes after intravenous administration of ¹⁴C-DL-8280 in 100 μCi/20mg/kg to JAW rabbit. Such care was taken in filling the carboxymethylcellulose paste into paranasal cavity, nasal cavity, oral cavity and external ear canal not to damage mechanically. Horizontal frozen sections parallel to mandibular basis were cut in 50cm thickness in a cryostadt. Blackening of ¹⁴C-DL-8280 was most significant in soft palate and its expanse which was apparently the same gland-like tissues as soft palate when stained which hematoxyline and eosin. Significant radioactivity was recognized in pharynx, the cartilage of external ear canal and muscle. The levels were low in septal cartilage, concha nasalis and cochlea. Blackening was scarcely seen in brain. Macro-autoradiography can be one of the useful means for the evaluation of chemotherapeutic agents for possible clinical application.

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Experimental and Pathohistological Study of theInfluence of Cefmenoxime Ototopical Solution on the Cochlear Organ

Kiichi SATO, Akira OGAWA, Takumi MIYAZAKI, Ritsuko DEJIMA

1984 Volume 30 Issue 2 Pages 157-166
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_157

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Ototopical solution with some kinds of antibiotics induced sensorineural deafness, if it was administered to the middle ear for long duration. By the above reason, it is important examination toclarify the ototoxicity of new developing ototopical solution of CMX (cefmenoxime) before clinical application. 31 animals of Hartley strained guinea pigs were used in this study. In 28 animals, after performing of artificial perforation at each ear drum, eachleft sided middle ear cavity was received 1% CMX ototopical solution 0.2 ml for 5 days. Three animals were received 1% CMX through the minute tubes which were touched with left middle ear cavity. Other right sided ear cavities were received 0.5% CP ototopical solution in 6 animals, 0.3% GM in 5 animals and2.0% KM in 5 animals. Among the remained animals, right cochleae of 8 animals were destroyed by surgery for the purpose of unilateral ABR recording. After performing of artificial perforation, right middle ear cavities of 4 animals were observed without administration of drug, and 3 animals of control group were not received any treatment. Afterfinishing the above procedure, each animal wasfixed by the method of intravitalfixation with 10% neutral formalin solution for pathohistological examination. The microscopic observation was focused the damage of Corti's organ, especially degeneration of the hair cells. As the results of the above experimental procedure, no remarkable changes of Corti's organ were present in 31 ears, which were received CMX. Degeneration of outer hair cells at lower part of basal turn was appeared in only one animals of KM receiving animals.

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Clinical Effect of Ketotifen Syrup Against Nasal Allergy in Children

Kaoru TOSAKA, Keisuke MASUYAMA, Kenjiro KITAO, Yuko KITAO, Takeru ISHI ...

1984 Volume 30 Issue 2 Pages 167-175
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_167

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Twenty eight children (6-15y), who were suffered from nasal allergy, were treated with Ketotifen syrup. Patients received Ketotifen syrup (0.8-2.0mg/day) in two divided dose for oral administration. And we obtained following results.(1) The efficacy rate in sneezing attack was 65.4%, in nasal discharge was 52%, in nasal obstruction was 62.5%.(2) Some improvements in at least one of three major symptoms were noted within 3 days after administration of the drug in 14.3% of the patients, within 1 week in 60.7%, within 2 weeks in 75%, within 3 weeks in 78.6%.(3) Side effect was observed only in one patient with erythema. These results suggested that Ketotifen syrup was highly effective in the treatment of nasal allergy in children.

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The Content of β-Endorphin andCatecholamine in Response to Cold Pressor Test in Patients with Nasal Allergy

Hitoshi MAEDA, Tetsuzo FUZITANI

1984 Volume 30 Issue 2 Pages 176-182
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_176

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Various kinds of stress may contribute to develop the symptom of nasal allergy. The plasma content of Noradrenalin (N. A.) and β-Endorphin (β-End) was measured in response to Cold Pressor Test (CPT) loaded as a stress factor in 11 patients with nasal allergy and in 10 healthy controls. N. A. was measured by HPLC with a voltammeter and β-End by radioimmunoassay. Plasma N. A. is an appropriate index of sympathetic nervous function and β-End is a parameter of emotional stress. Blood pressure significantly raised by CPT in both groups. Plasma N. A. and β-End significantly increased by CTP in the allergic group. Thus, patients with nasal allergy have hyperreactivity of the sympathetic nervous system and emotional hyperresponsiveness by CPT. Cornell Medical Index (CMI) of 121 subjects with nasal allergy was investigated, resulting in a characteristic tendency of inadequacy, hypersensitivity, anger and especially easy irritability. These excessive reactions which are believed to associate the central pathway may have a causative relationship to the nasal hyperreactivity of nasal allergy.

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[title in Japanese]

[in Japanese]

1984 Volume 30 Issue 2 Pages 183-185
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_183

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[in Japanese]

1984 Volume 30 Issue 2 Pages 187-189
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_187

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[in Japanese]

1984 Volume 30 Issue 2 Pages 190-195
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_190

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[title in Japanese]

[in Japanese]

1984 Volume 30 Issue 2 Pages 196-198
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_196

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[title in Japanese]

[in Japanese]

1984 Volume 30 Issue 2 Pages 199-203
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_199

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[title in Japanese]

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1984 Volume 30 Issue 2 Pages 204-207
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_204

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1984 Volume 30 Issue 2 Pages 208-210
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_208

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[in Japanese]

1984 Volume 30 Issue 2 Pages 211-214
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_211

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[title in Japanese]

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1984 Volume 30 Issue 2 Pages 215-218
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_215

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1984 Volume 30 Issue 2 Pages 219-221
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_219

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[title in Japanese]

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1984 Volume 30 Issue 2 Pages 222-225
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_222

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1984 Volume 30 Issue 2 Pages 226-228
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_226

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[title in Japanese]

[in Japanese]

1984 Volume 30 Issue 2 Pages 229-231
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_229

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[title in Japanese]

[in Japanese]

1984 Volume 30 Issue 2 Pages 232-235
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_232

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Clinical case study of head and neck cancer chemotherapy combined with Angiotensin II

Toshiichi AWATAGUCHI, Tomonori TAKASAKA, Jun KUSAKARI, Kazutomo KAWAMO ...

1984 Volume 30 Issue 2 Pages 236-240
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_236

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The enhancement of cancer chemotherapy by Angiotensin-induced Hypertension is based on the fact that the autoregulation of blood flow is lacking in tumor tissues. Therefore, the selective increase in tumor blood flow enhances the chemotherapeutic effect by increasing the delivery of anticancer drug administrated systemically. We induced hypertension with Angiotensin II in 11 head and neck cancer patients when anti-cancer drugs were administrated systemically or infused into the artery. The good clinical response was observed in 5 out of 11 (45.5%)(5 cases including 2 complete (CR) and 3 partial responses (PR)). These results indicate that the effect of anti-cancer drugs was markedly enhanced by this procedure. Furthermore, the effect of the drugs appeared in far earlier than in the treatment without induced hypertension.

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1984 Volume 30 Issue 2 Pages 241-242
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_241

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[title in Japanese]

[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...

1984 Volume 30 Issue 2 Pages 243-246
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_243

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1984 Volume 30 Issue 2 Pages 247-251
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_247

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1984 Volume 30 Issue 2 Pages 252-254
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_252

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[title in Japanese]

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1984 Volume 30 Issue 2 Pages 255-258
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_255

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[title in Japanese]

[in Japanese]

1984 Volume 30 Issue 2 Pages 259-261
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_259

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[title in Japanese]

[in Japanese]

1984 Volume 30 Issue 2 Pages 262-265
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_262

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[title in Japanese]

[in Japanese]

1984 Volume 30 Issue 2 Pages 266-267
Published: March 20, 1984
Released on J-STAGE: May 10, 2013

DOIhttps://doi.org/10.11334/jibi1954.30.2_266

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