We examined cases of dental maxillary sinusitis in patients treated with endoscopic endonasalsinus surgery (ESS). Even in patients with dental maxillary sinusitis, inflammation was confined to half or less of the maxillary sinus, and more than half of the patients had inflammation spreading to other paranasal sinuses. In addition, in most cases, lower and middle nasal turbinate formation, nasal septum remediation, and other nasal cavity improvement proce. Furthermore, in 3 of the 6 patients diagnosed with apical periodontitis, the symptoms did not improve with tooth extraction alone, and ESS was performed after tooth extraction. ESS, which treats multiple paranasal sinuses at the same time and can be simultaneously combined with nasal cavity improvement procedures, is useful for treating dental maxillary sinusitis that does not show improvement with conservative treatment.

We performed super-selective intraarterial injection chemotherapy combination radiation therapy (RADPLAT) by administering CDDP 100 mg/m²/session for advanced maxillary sinus cancer every week during the treatment course. We examined the histological curative effect in 25 cases treated from February 2011 to August 2017. There were no cases of a complete response according to an evaluation by RECIST with 40 Gy irradiation, but a partial response was noted in 23 cases, while stable disease and progressive disease were noted in one case each. As administering a full dose of radiation treatment (70 Gy) was deemed to be difficult, we performed surgery in all cases. Approximately half (n=13) of all cases were found to have Grade 3 disease according to the established criteria. In 1 Grade 1a case (T4a, intraarterial injection 4 times), we performed an additional 30 Gy of irradiation because the resected edge of the maxillary sinus rear wall showed positivity. No consistent tendency was noted in the association between the T classification, the number of intraarterial injections, the differentiation degree and the findings of the histological curative effect of the tumor. In addition, the evaluation by RECIST and the evaluation of the histological curative effect showed no particular correlation in these cases.

We treated 26 cases of cervical lymph node metastasis from unknown primary sites at Kyushu University between 2007 and 2016. The N classifications of the cervical lymph nodes were as follows：N1, 1；N2, 23；N3, 2. The histopathological diagnosis of the cervical lymph nodes was squamous cell carcinoma in all cases. The 3-year overall survival rate was 52%. Seven cases showed the expression of p16 in the metastatic lymph node. The primary site was found in 5 of 7 p16 positive cases. They primary tumor sites were the tonsil, (n = 4) and the hypopharynx (n = 1). Further study usingof a larger cohort is therefore needed.

We retrospectively reviewed the safety and efficacy of treatment with lenvatinib for thyroid cancer. Eight patients with thyroid cancer (five with papillary carcinoma, two with medullary carcinoma, and one with squamous cell carcinoma) were analyzed. Five patients were male, and three were female. The median age was 67.8 years. Five patients were treated for recurrent disease after definitive therapy, and three were treated as primary therapy for metastatic or unresectable disease. The median overall survival was 12.9 months. The best objective responses were a partial response for six cases, stable disease for one case, and progressive disease for one case. The response rate was 75%. Common adverse events were as follows：hypertension, fatigue, palmar-plantar erythrodysesthesia syndrome, diarrhea, nausea/vomiting, and decreased platelet count. All patients experienced drug withdrawal and dose reduction. All but one patients achieved disease control at three months. At 12 months, a long-term response had been achieved by 5 patients. A rare case of thyroid squamous cell carcinoma is described.

Receiving a cochlear implant is the only way for deaf patients to acquire hearing. Recently, bilateral early implantation has been the ideal solution for providing the best hearing outcome. In Japan, the number of patients with bilateral cochlear implants has gradually increased since 2014 when the new criterion for pediatric cochlear implantation was approved. In this situation, cosmetic considerations for bilateral cochlear implants are becoming increasingly important. To implant bilateral implants symmetrically, several pre-surgical tips need to be reviewed. In this report, we introduce our pre-surgical tips concerning the implantation of devices at the same position on both sides.