A clinical survey was mede of 24 cases of laryngeal cancer treated with interstitial radium irradiation during the period of 1937 to 1956 at the Otorhinolaryngical Clinic, Faculty of Medicine, Kyushu University and 9 of them who were also cases of perichondritis were subjected to a pathohistological examination. The following was the conclusion reached.
1) Histologically, the cases examined were all those of cancroid, the paients being all male.
2) Recovery was effected in 68.8% of cases, relapse noted in 31.2%, and perichondritis induced in 39.1%.
3) Hawever, of those cases in which the treatment was rightly indicated 83.3% were cured, illustrating the importance of a careful choice of condition in employing this radium therapy.
4) Of the cases of perichondritis, one was of perichondritis radiochirurugica and the rest were of perichondritis radiotherapeutica.
5) Perichondritis was acute late-stage perichondritis in type in almost all cases, developing 5 months to 2 years after operation.
6) The fast factor in the development of perichondritis in these cases was radiuminduced regressive degeneration of the thyroid cartilage and its surrounding tissue. The epiglottis and the hyoid bone were also affected when the irradiation was particulary intense.
7) 2500 mg-hour appeared to be the maximum total dose if perichondritis was to be effectually prevented.
8) The development of perichondritis was extremely high in incidence amang the patients retreated. It seemed necessary for cure of the tumor and prevention of the possible development of perichondritis that total laryngectomy schould be performed in relaped laryngeal cancer occuring after interstitial radium therapy.

View full abstract

Electromyographic study of the M. glosso-palatinus and M. pharyngo-palatinus was carried out In 60 cases of chronic palatine tonsilitis and 4 of the tumor of the palatine tonsil, with the following conclusion reached.
1) The two muscles were practically normal in chronic palatine tonsilitis.
2) The two muscles were low in voltage in chronic palatine tonsilitis, as examined 7 to 10 days after tonsilectomy for the disease.
3) The two muscles were found either practically unaffected or rather strengthened, and the articulation structure improved instead of being impaired after tonsilectomy in these cases in which the surgical trauma wound was healed and the palatine arches left unremoved, without any scar formed or any adhesion produced.
4) M. pharyngo-palatinus assumed the nature of M. glosso-palatinus and became lowered in voltage in those cases in which adhesion of the two palatine arches was induced after recovery of the wound.
5) The two muscles gave off no electric discharge and the articulation structure appeared to be disturbed when there was a cicatrix formed after recovery of the wound.
6) Removel of the palatine tonsil caused no disturbance of the articulation structure in case the coating membranes were separated with suffieient care and neither palatine arch impaired.
7) The two muscles gave off no discharge and the articulation structure appeared disturbed when there was cicatri caused after tonsilectomy for a tumor of the palatine tonsil.

View full abstract

Thirty-three cases of cancer of the larynx were divided into four groups according as the cancer was intrinsic, endolaryngeal, subglottic or extrinsic and in each group of cases was made an electromyographic examination of M. vocalis,(M. internus), M. cricoarytaenoideus dorsalis (M. posticus) M. arytaenoideus,(M. transversus), M. cricothyreoideus (M. anticus), and M. cricoarytaenoideus lateralis (M. lateralis).
Result.
1) During vocal activity in humans the contracting power of the inner laryngeal muscles is varied in decreasing order for M. anticus, M. lateralis, M. transversus, M. Posticus, and M. vocalis.
2) M. vocalis on the affected side, only invaded in an intrinsic cancer.
3) In an endolaryngealcancer, M. vocalis, and M. posticus on the affected side, and occasionally M. vocalis and M. lateralis on the unaffectedside, become attacked.
4) In a subglottic cancer, M. vocalis, and M. posticus on the affected side and occasionally M. anticus and M. lateralis, and M. vocalis, and M. posticus on the unaffected side are attcked.
5) In an extrinsic cancer the muscles infiltrated give off no electric discharg, and of those apparently uninfiltrated and normal same have their electric activity reduced or eliminated and others not baffling any clear-ent distinction.

View full abstract

The clinical picture of chronic sinusitis……particularly that of punctates form, and of the contrast-media excreting function of the affected sinus, the pathological picture of, and the radical treatment for the disease, the possible relationship between Alergy and this disease, and so forth were observed and examined in children with the following results:
1) a) Examination by puncture showed that the maxillary sinus contained a secretionaaccumulation in 95 % of 113 cases in 79 patients and that the accumulation was so large as to present the appearance of empyema in no small number of advanced cases.
b) A test for the excretionsfunction of Moljodol of the maxillary sinus disclosed that the function was disturbed more than moderately in the majority of 87 cases in 61 patients.
These two findings, a) and b), showed that the incidence of the condition was as highamong children as among adult.
2) The result of Luc-Caldwell's operation performed on 33 children, 10 to 14 years old, proved that the operation could easily be performed under local anesthesia on children ten or more years old, that the remote result of the operation was remarkably satisfactory in 72% of the cases, and that the operation was not followed by the development of any marked sequla. It appears from the result that the radical surgical treatment may safely be indicated in some particular types of sinusitis in children.
3) A pathologic examination of the mucosa of the maxillary sinus in 58 cases in 33 patients showed that the mucosa, though essentially alike in adults and in children, was less fibrillated in the latter, indicating that chronic sinusitis in children may be an initial or a little more advanced stage of development in almost all cases.
4) The relationship between chronic sinustiis and allergy in children was investigated by examining: a) the interrelationship in 58 cases of the predisposition to allergy, the increase in the number of eosinophils in the blood and sinusal secretion, and pale edematous swelling of the nasal conchae and the presence of nasal polypi b) the interrelationship in 33 cases of the pathohistologic picture of the area the edema and eosinophil infiltration occurring there, in particular,the predisposition to allergy, and the increase in the number of eosinophils in the blood and sinusal secretion. The result showed that the disease was related to allergy of the atopic type in 17.2% of cases, as indicated by the first examination a), and in 18.0%, as shown by the second examination b). The figures make it conceivable that chronic sinusitis originating from allergy of the atopic type is extremely low in incidence among children in Japan.

View full abstract