Six cases of the cervical esophageal carcinoma were treated with bleomycin. The drug was effective even for the advanced cancer. Excluding two cases, four of them are going on well.
By administration of bleomycin, the remarkable degeneration and necrosis of the tumor cells were microscopically observed. When the drug was applied during radiation therapy, most cancer cells were destroyed.
The combined use of
60Co 3000 rads and bleomycin was thought to be more effective than irradiation of
60Co 6000-7000 rads. In other words, when bleomycin was used during radiation, it seemed to act multiplicatively on the tumor cells. Based on the histological changes of the tumor cells, some cases of the cervical esophageal carcinoma might be cured by the adequate combined treatment of bleomycin 200-300 mg and irradiation of
60Co 4000-5000 rads in tumor dose.
Direct injections of bleomycin to the primary tumor or to the metastatic neck tumor through the skin were significantly effective.
No favorable result was obtained in the case whom bleomycin was given after radiation therapy.
Administration of bleomycin produced the ill effects such as fever, anorexia and pigmentation of the skin, but these were not so severe. Even in the cases which were treated with the combined method of bleomycin and irradiation, no leukopenia occurred.
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