We herein report a case of Ramsay Hunt syndrome with generalized herpes zoster, which is considered to be relatively rare. A 74-year-old male with a past history of diabetes mellitus and pancreatic carcinoma, demonstrated left aural vesicles occurring with a febrile attack. Within 24 hours of admission to the hospital, eruptions spread systemically and ipsilateral facial paralysis also developed. He was therefore diagnosed to have Ramsay Hunt syndrome. Since the grade of facial palsy was severe, 60 mg of predonisolone and 3,000 mg of valacyclovir were thus administered. Electroneuronography (ENoG), showed total denervation, and a rehabilitation program was therefore designed for the patient. His facial movement slowly recovered, and pathological synkinesis was thereafter observed. A serological examination showed a significant elevation in the anti-VZV immunoglobulin level. It is therefore important, but clinically difficult to differentiate generalized herpes zoster from a varicella-zoster virus (VZV) reinfection. Viremia following VZV reactivation might cause the onset of generalized herpetic eruptions. In addition, one of the factors for generalized herpes zoster is supposed to be an immunosuppressive condition based on such factors as a relatively old age, the past history of the diabetes mellitus and the pancreatic cancer. Considering the outcome of the present case, the question remains regarding whether or not high dose steroids and drip infusion of acyclovir should have been administered.
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