A histological stromal reaction, cell infiltration in particular, and pathological course in laryngeal cancer was carried out in whole sections of 67 larynxes removed under diagnosis of carcinoma, with the following results:
The course was relatively favorable in cases in which the advancing margin of the lesion had infiltrating cells closely collected about it.
Comparative examination of specimen tissues, surgically removed and taken out for autopsy, disclosed that cell infiltration was considerably reduced with the approach of death.
The lesion was slow to sprout and the rate of long-term survival high in all cases in which the cancer had thick cell infiltration and increased connective-tissue proliferation about its advancing margin.
It was impossible to deny that in laryngeal cancer too stromal reaction of some kind is a form of vital reaction against cancer.

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The study on the function of auditory organ related to the cervical sympathetics is one of the recent problems. In our experiments with cats, the electrical stimulation of the superior cervical sympathetic ganglion revealed the remarkable decrease of reacting potential of cochlear microphonics and its lowering of response was especially significant in high tone area.
When the sympathetics were blocked by topical novocainization the marked increase of responsive microphonic potential, in low and middle tone area, was observed, and at 2 hours after topical treatment, in general, the responsive change recovered to the initial potential value.
The excision of the sympethetic ganglion resulted in decrease of the microphonics which was remarkable in middle and high tone area, and this change in response generally recovered at 2 hours after operation. The extirpation of the same ganglion after electrical stimulation excessively accelerated the recovery to initial potential value and this phenomenon was markedly in low tone area.
Accordingly it is supposed that the superior cervical ganglion has an intimate relation to auditory organ. And authors summarize that the vasomotoric changes of the ladyrinthine artery is affected by the behavior of this ganglion, namely hyperfunction or hypofunction of this ganglion results in the constriction or dilation of the labyrinthine artery respectively, and then the ischemia or stasis diminishes the labyrinthine function, on the contrary, the profuse supply of blood stream promotes labyrinthine function.

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The number of ceruminous glands and areas in which they are distributed in fetal and extra-uterine life were examined with following conclusion' reached.
1) Ceruminous glands are not yet found in the 16th week of fetal life.
2) In the 18 th week of fetal life one cerminous gland is found on either side, not infrequently on one side of the archecenter of hair.
3) The archecenter of each ceruminous gland begins to divide into an excretory part and a duct in the 21 st week and assumes, in the 24 th week, the complete form of a gland in any area of the auditory canal, with its excretory part located in the corium. The number of ceruminous glands, amounting to 175 or so, is greatest in the middle part of the external auditory canal and reduced by degrees towards its opening and the myrinx.
4) 189 cerminous glands are counted in the 28 th week of fetal life, 182 in the 32nd, and 193 in the 38th.
5) They number 196 in a child of 5 years old 212 in a person of 30 years old. The glands are ill-defined and uncountable with their lumen enlarged in old persons.
6) The glands are most abundant in the middle part of the external auditery canal at any stage of life, in fetal life and in old age.
7) The cerminous glands appear first in the lower wall, the number of the glands increase medialwards and decrease beyond the middle part, no such glands being found in the bony part of the canal. The glands appear to be distributed more or less in greater numbers in the upper wall than in any other part of the canal wall.
8) Most of the glands are formed at the same time. Those formed afterwards are very small in number and few or none are formed after birth.
9) The glands found in the external auditory canal numbered some 190 to 210 in one case.

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Nowadays, a more detailed study should be desired, though many studies on the changes of auditory acuity of the experimental animals before and after of experimental acoustic trauma have been carried out. On the other hand we know the difficulty to get some satisfactory expeimental procedure, estimating auditory threshold of animals.
The author reported the objective audiometry of human beings who were built the conditioned salivary response by Pavlov's method in the previous paper.
Now the author has been studied to estimate the auditory threshold of the dog, cat and guinea-pig as a same chart of human audiogram, by use of conditioned response method.
In this way I could get useful audiograms to see the hearing variation after experimental injuries for many kinds of animals in accordance with various conditions, The most important problem in the audiometry by means of conditioned response is the conditioning duration.
Culler and Finch said that they repeated conditioning move more than 100 times in the differentiating experiments for pure tones.
Schuknecht reported that he expended 13 hours to get an audiogram by the cat.
In the author's experiment 10 or 20 days were demanded to take an audiogram of a dog when it was selected. The guinea-pigs required the longest term to taken their complete audiograms and the term of 2 months was necessary for this purpose. A excellent noisegenerator was prepared for these experimental serieses by author, making it possible to get intense noise of various frequency-characteristics. The author studied the following experiments with the conditioned dogs, cats and guinea-pigs impaired by acoustic trauma.
1) On the injuries by a definete intense thermal noise in different durations of acoustic trauma.
2) On the state of recovery after exposing to the noises in different durations.
3) On the injuries by the different intense noises in a definete duration.
4) On the state of impairments by different charateristic but with the same intensity.
5) On the difference among the continuous and discontinuous thermal noise as acoustic trauma.
6) On the difference of impairment among the dog, cat and guinea-pig which are exposed to intense thermal noises in short time duration.
7) Long time exposing experiments to intense noise,
were performed in the extent of such a condition where the experiment with human body might be impossible concerning to the tolerance.

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This is a cutline report on the result of our clinical and patho-histological study of socalled tonsillitic heart disease.
Tonsillectomy was performed in 31cases of various heart diseases with subjective and objective symptoms of chronic palatine tonsillitis, and 32 tonsils extirpated from 19 of the 31 cases were subjected to patho-histological examination.
What were kept in view as matters of the highest clinical importance:
1) the method of diagnosis;
2) possibility of safe operations; and
3) probability of desired remote results.
of the conditions to be diagnosed, chronic palatine tonsillitis and heart disease, the latter was left untreated as a conbition to be examined in internal medicine and the former subjected to surgical treatment. The operation was performed by Prof. Sasaki's method, without using the snare at any stage. Death caused 4days after the operation in one case was apparently ascribable to cardiac insufficiency due to insufficient care on our part and not to the operation itself, tonsillectomy being no dangerous operation when performed with sufficient care.
Examination of the remote result of the operation in 20 cases showed that subacute infectious endocarditis was practically cured in 3 of 4 cases and much improved in the remaining one, cardiac neurosis almost cured in either of 2 cases, spasmodic disorder of heart best almost cured in either of 2 cases, and the condition more or less improved in the rest of the 20 cases except in one in which heart disease resulted in death just 5 years after the operation.
Histological examination disclosed as the more prominent features of this type of tonsillitis that
(1) marked changes were produced in the crypts; particulary in the Fossa tonsillaris superior (Sasaki), indicating the occurrence of acute and chronic types of inflammation mixed together; that
(2) there were some vascular changes produced, such as inflammation and thickening of the lining membranes of small arteries; that
(3) the walls of small arteries and surrounding tissue were in state of fibrous swelling, with eosinophils appearing in them; that
(4) 90.6% of the entire tissue was composed of bacterial masses and 75% of masses of actinomyces; and that
(5) there were cysts of different kinds formed in considerable numbers.

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