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Volume 25, Issue 2
Displaying 1-15 of 15 articles from this issue
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Hiro-omi TAKAHASHI, Makito OKAMOTO, Touru SUZUKI, Akira SAITO, Kazuo Y ...1979 Volume 25 Issue 2 Pages 431-435
Published: March 20, 1979
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSBCG, OK-432, SPG or PS-K, either of which is now considered to be an effective drug for cancer immunotherapy, has been used together with radiotherapy or operation in patients with head and neck cancer in our clinic since 1973. The clinical results so far obtained are summerized as follows.
The local and systemic administration of BCG was done in our clinic. Especially in patients with cancer of maxilla treated with local application, most excellent results were obtained, showing 2-years survival rate of 86.7% (13/15).
OK-432 of 10 KE a time was locally applied to 7 cases of maxillary cancer. As compared with BCG, the local reaction was relatively weak but no side effect was noted. At present, 6 out of 7 cases are surviving over 1 year without recurrence.
SPG was administered 5-20mg a time to 25 patients with head and neck cancer. PHA skin reaction was stimulated and an increase of T cells in the peripheral blood counted more than 1000/mm3 was noted in 47.1% of these patients.
PS-K was administered to 12 cases at the same time with radiotherapy. It was noted by the decrease of T cells in the peripheral blood due to radiotherapy were prohibited as compared with 12 control cases in which radiotherapy was singly performed.View full abstractDownload PDF (5705K) -
Hiro-omi TAKAHASHI, Makito OKAMOTO, Toru SUZUKI, Akira SAITO, Kazuo YA ...1979 Volume 25 Issue 2 Pages 436-442
Published: March 20, 1979
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSSPG is a new polysaccharide which has been extracted from the fermentation juice of Suehirotake (Schizophyllum commune). It has been reported to exhibit a unique antitumor effect, based on its immunoactivity enhancing effect.
Since October 1976, our clinical study has been carried out 26 patients with head and neck cancer who had been treated with SPG, singly or combination with other therapies. SPG was administrated intramuscularly, intravenously or locally in the dosage of 5-30mg for the longest possible periods. The frequency of administration was adjusted to every day, every other day, once or twice per week or month, depending on the conditions of the patients.
No adverse reaction in hematogenesis organ, liver and kidney was observed.
In most cases, immunoglobrin and aiantitrypsin values were returning towards normal ranges after treatment with SPG. Peripheral blood T lymphocyte was increased in 8 out of 17 cases in which its time course could be examined (over 1000/mm3, over 60% respectively). Positive PPD skin reaction was seen more frequently in patients treated with SPG-BCG combination, though some cases treated with SPG alone gave positive reaction.
These results indicate that SPG is capable of enhancing nonspesific cellular immunoactivity in patient with head and neck cancer, restoring immunoglobulin, aiantitrypsin to normal levels.View full abstractDownload PDF (625K) -
A Possible Role of Plasmin for the Development of Laryngeal EdemaTadayoshi KOSUGI, Tamotsu MORIMITSU, Matsuo HAMAYA1979 Volume 25 Issue 2 Pages 443-447
Published: March 20, 1979
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSIn 1966 Hiroto reported the of of systemic administration of antiplasminic drug for acute laryngitis. However, the prolonged medication of this drug might exacerbate the inflammatory process because of the inhibition of the local fibrinolysis due to the abnormality of the blood fibrinogen metabolism. The topical application of this drug therefore should be more benificial than the systemic administration. In this paper, the clinical results in 20 cases of acute laryngitis, in whom 1ml of 5% Transamin was inhaled through a nebulizer once a day for about a week, were reported. The results obtained were remarkable effect in 5 cases, moderate effect in 9 cases, slight effect in 3 cases and no effect in 3 cases. The effectiveness of this treatment was recognized in about 70% of the patients.
From this clinical experiences, it was supposed that the laryngeal edema observed in acute laryngitis might be occured on the basis of the abnormality in plasmin and complement system in blood and furthermore in some cases the increase of fibrinolytic activity in local site and decrease of inhibitor of complement system act an important role in the inflammatory process in the larynx.View full abstractDownload PDF (667K) -
Youichi TORIYA, Midori NAGAI, Tadashi NAKASHIMA, Ikuichiro HIROTO1979 Volume 25 Issue 2 Pages 448-452
Published: March 20, 1979
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSThe relationship between cigarette smoking and polypoid lesions of the vocal fold, such as vascular polyp, singer's nodule, sessile polyp and polipoid hypertrophy, was statistically studied on 1620 cases of laryngeal diseases which consulted the outpatient clinic of Kyushu University Hospital for 4 years from 1966 to 1970.
The other laryngeal diseases excluding carcinoma were employed as the control group, in which the ratio of smoking was 54% in 643 male cases and 20% in 382 female cases. In vascular polyp, 75% of 161 male cases and 17% of female cases were cigarette smokers. It indicates that polyp is more frequently found in smoker than non-smoker in male cases; however, smoking is not considered to be a true origin of the polyp, since the sexual difference cannot be existent in the cause of this disease. In singer's nodule, 15% of 53 male cases and 10% of 71 female cases were found to be a smoker. It means that smoking is scarcely related to singer's nodule. In sessile polyp and polypoid hypertrophy, 76% of 59 male cases and 61% of 46 female cases belonged to the smoker's group. Therefore, it is concluded that smoking significantly plays an important part in occurence of these diseases.View full abstractDownload PDF (549K) -
Mamoru SUZUKI, Yoshiro SUGIMOTO, Seiichi KAWAMATA, Yasuo HARADA1979 Volume 25 Issue 2 Pages 453-457
Published: March 20, 1979
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSStatistical analysis of 39 BPPV (Benign Paroxysmal Postural Vertigo) cases was made in reference to clinical features and therapeutic prognosis. Eighty percent of the total cases were those aged from 30 to 60 years old. As a clinical symptom, rotatory vertigo was most common (84.6%), while tinnitus and hearing loss were uncommon (41%). All of the cases showed nystagmus of either rotatory or horizontal-rotatory type. Direction-fixed rotatory nystagmus was frequently observed in the positional nystagmus test, while direction-changing rotatory nystagmus was found in the positioning nystagmus test. Caloric and blood pressure test showed abnormal findings only in 23% and 7.7% respectively. For relief of vertigo, vasopressor, vasodilator agents, vitamines, sodium bicarbonate and tranquilizers were administered. As a whole, the vertiginous symptom subjectively relieved in 2 weeks after the initial treatment. Good prognosis is one of the features of BPPV. However, the postural vertigo of central lesions is to be ruled out in order to establish appropriate therapeutic schedule.View full abstractDownload PDF (657K) -
Naoko HIRASHIMA1979 Volume 25 Issue 2 Pages 458-462
Published: March 20, 1979
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSIn 1974-1978, the auther experienced 9 patients with sensoryneural deafness in pregnancy. Two patients had a bilateral hearing loss and the other seven a unilateral hearing loss. One patient developed total deafness with vertigo, nausea and vomitting and the other eight partial deafness without vertigo. They were treated with intravenous injection of a contrast media; methylglucamine and sodium diatrizoate or methyl-glucamine and sodium iodamide. Six of them showed a recovery of their hearing.View full abstractDownload PDF (640K) -
Hisao KITAMURA, Tadao WAKUTANI, Hitokazu KOBAYASHI1979 Volume 25 Issue 2 Pages 463-467
Published: March 20, 1979
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSA case of mucoepidermoid carcinoma at the base of the tongue was reported. The patient was a 28-year-old woman and complained of sore throat for about three years. The tumor was surgically removed with surrounding tissue. Its size was little-finger's head size. The tumor was determined well-differentiated low grade mucoepidermoid carcinoma by histpathological examination. She has had no evidence of local recurrence and distant metastasis during 21 months after the operation. She has left no functional disorders.
According to the previous literatures, surgical excision is the treatment of the first choice for this type of carcinoma.View full abstractDownload PDF (3402K) -
Masakazu OHNO, Ikuo OHNO, Makoto YAMAMOTO1979 Volume 25 Issue 2 Pages 468-471
Published: March 20, 1979
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSA 64 year-old man with chronic arsenical poisoning was diagnosed as having supraglottic cancer (T2N0M0). The carcinogenicity of arsenicals has been clinically and epidemiologically confirmed. The laryngeal cancer which has been induced by arsenicals is extremely rare, still we believe the cause of this case is these metalloids for reasons of following described.
1) He had been exposed for a long time to the dust contaminated with arsenicals.
2) He was suffered from the chronic arsenical poisoning, including dermal neoplastic lesion (basal cell carcinoma) of trunk.
3) The tumor was present in the middle portion of the supraglottic region, where was much susceptible to the chemical stimulants.
4) He had been a light smoker. The chronic arsenical poisoning was further discussed from the otorhinolaryngological aspect.View full abstractDownload PDF (3000K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1979 Volume 25 Issue 2 Pages 472-477
Published: March 20, 1979
Released on J-STAGE: May 10, 2013
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Satoshi FUKUDA, Seiichi YAMAJI, Kohji HASHIMOTO, Yoshihiko TERAYAMA1979 Volume 25 Issue 2 Pages 478-485
Published: March 20, 1979
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSDelayed hypersensitivity skin reactions to four recall antigens (candida extract, candida broth, SK/SD, PPD) and one new antigen (DNCB) were examined as para-meters of host immune response in 81 patients with malignant head and neck tumors. The results were as follows. 1) Skin reactions to Candida extract, PPD DNCB (especially to candida extract) were significantly decreased compared to the normal controls and benign diseases. The tendency became more significant in the advanced cancer patients. 2) The incidence of anergy increased compared to the normal controls and benign diseases, and in malignancy the incidence of anergy increased when the disease was advanced and the general physical condition of the patients was regarded as poor. 3) When the various delayed hypersensitivity skin reactions including candida extract are examined in patients with malignant head and neck tumors, the results bring valuable information for host cellulary immunity, judgment of prognosis, and possible detection of the recurrence of the cancer.View full abstractDownload PDF (1000K) -
Toshio HAGIWARA, Tamotsu MORIMITSU, Shizuo KOMUNE1979 Volume 25 Issue 2 Pages 486-492
Published: March 20, 1979
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSA depression of cochlear microphonics (CM) due to intermittent intense sound stimuli was observed in normal and CoQio treated guinea pigs. It was studied whether an effect of a certain medicine on cochlear fatigue could be detected from this experimental method.
1) CM was recorded by the differential electrode method from the basal turn of the cochlea. Intensity function of CM was derived in order to monitor the difference in susceptibility among the individuals.
2) An intense pure tone stimulus of 1 min. duration and 5 min. interval was repeated 10 times. The chronic depression rate and the temporary depression rate of CM after each stimulus were observed.
3) The result for the control animals indicated that the chronic depression of CM progressed in an exponential way during the stimulation was repeated, while the temporary depression rate after each stimulus kept approximately constant value.
4) Being compared with the control group, the chronic depression of CoQio treated group was slighter and the temporary depression rate of it was similar.
5) A discussion was made about the effect of CoQ10 on auditory fatigue and some technical problems concerned with the experimental procedure.View full abstractDownload PDF (763K) -
OK-432 for the PatientRyo SASAKI, Keiko ANDO1979 Volume 25 Issue 2 Pages 493-498
Published: March 20, 1979
Released on J-STAGE: May 10, 2013
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[in Japanese]1979 Volume 25 Issue 2 Pages 499-500
Published: March 20, 1979
Released on J-STAGE: May 10, 2013
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[in Japanese]1979 Volume 25 Issue 2 Pages 501-509
Published: March 20, 1979
Released on J-STAGE: May 10, 2013
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[in Japanese]1979 Volume 25 Issue 2 Pages 510-518
Published: March 20, 1979
Released on J-STAGE: May 10, 2013
JOURNAL FREE ACCESSDownload PDF (1157K)
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