jibi to rinsho
Online ISSN : 2185-1034
Print ISSN : 0447-7227
ISSN-L : 0447-7227
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Volume 56, Issue Suppl.1
Displaying 1-15 of 15 articles from this issue
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The 15th Japan Head & Neck Cancer Chemotherapy Conference Group (JHNCCCG)
  • [title in Japanese]
    2010 Volume 56 Issue Suppl.1 Pages S1-S2
    Published: 2010
    Released on J-STAGE: November 01, 2011
    DOIhttps://doi.org/10.11334/jibi.56.S1
    JOURNAL FREE ACCESS
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  • Surgical approach for T1 - T2 oropharyngeal cancers
    Kenji OKAMI, Ryousuke SUGIMOTO, Akihiro SAKAI, Koji EBISUMOTO, Daisuke ...
    2010 Volume 56 Issue Suppl.1 Pages S3-S11
    Published: 2010
    Released on J-STAGE: November 01, 2011
    DOIhttps://doi.org/10.11334/jibi.56.S3
    JOURNAL FREE ACCESS
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    According to NCCN guideline, the treatment modality of T1-2, N0-1 oropharyngeal cancer (OPC) includes the definitive radiation therapy, the excision of the primary and neck dissection, and the chemoradiation (only for T1-2, N1 ). We report the operation indication and the surgical approach for T1-2, N0-1 oropharyngeal cancers. Twenty - eight OPC patients were treated at Tokai University hospital. Surgery was indicated for 14 (TLO for 6, lower cheek flap approach for 7, and mandibularswing approach for 1). Other 14 cases underwent radiation therapy. Five year disease specific survival rate was 100% in surgery group, and 69% for radiation group. Minimally invasive surgery and open surgery with Gehanno's reconstruction were effective for the function preserving treatment.
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  • Chemoradiotherapy for T1/T2 oropharyngeal squamous cell carcinoma
    Takenori OGAWA, Kiyoto SHIGA, Yukinori ASADA, Kengo KATO, Kazuto MATSU ...
    2010 Volume 56 Issue Suppl.1 Pages S12-S20
    Published: 2010
    Released on J-STAGE: November 01, 2011
    DOIhttps://doi.org/10.11334/jibi.56.S12
    JOURNAL FREE ACCESS
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    The treatment strategy for T1/T2 oropharyngeal squamous cell carcinoma has been controversial. To assess appropriate therapies including surgical treatment and (chemo) radiotherapy ((C) RT), we conducted a retrospective chart review of 58 squamous cell carcinomas of oropharynx in 55 cases treated by (C)RT. These cases included 48 males and 7 females, aged from 38 to 85 years (median age : 68 years old). The primary sites included the upper wall in 3 cases, the anterior wall in 8 cases, the lateral wall in 46 cases and the posterior wall in 1 case, respectively. The disease specific 3-year survival rates of patients with stage I, II, III and IVa tumors were 59.3%, 75.4%, 71.4% and 78.6%, respectively. There were no statistical differences between these survival rates. We also found no statistical differences between the survival rates of patients classified according to their primary sites. However, we could emphasize the benefit of (C)RT in T2N0 cases. Furthermore, we conclude that the smoking was found to portray poor prognostic factor in groups of oropharyngeal cancer patients treated by (C)RT.
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  • Human papillomavirus (HPV) and oropharyngeal squamous cell carcinoma
    Yutaka TOKUMARU, Masato FUJII, Noboru HABU, Yoko YAJIMA
    2010 Volume 56 Issue Suppl.1 Pages S21-S24
    Published: 2010
    Released on J-STAGE: November 01, 2011
    DOIhttps://doi.org/10.11334/jibi.56.S21
    JOURNAL FREE ACCESS
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    Human papillomavirus (HPV) has previously been reported to be associated with squamous cell carcinoma of the head and neck (HNSCC). Especially subgroup of oropharyngeal squamous cell carcinoma (OPSCC) revealed the presence of high risk types of HPV in tumor cells, predominantly HPV type 16. In the USA, incidence rates for HNSCC of HPV sites such as the tongue base and tonsil were increasing whereas the rates of remainder of head and neck sites were decreasing which is consistent with reduced levels of cigarette smoking. HPV associated OPSCC has a molecular, epidemiological and clinical profiles that is distinct from non-HPV associated HNSCC. HPV-positive tumors are more likely than HPV-negative tumors to occur in the nonsmoker and ex-smoker. Furthermore HPV-positive tumors were less likely to harbor p53 mutations than HPV-negative tumors. Several studies have revealed that OPSCC patients with HPV-positive have a better prognosis than patients with HPV-negative. We should need to recognize the differences in the HPV positive OPSCC, suggesting novel treatment strategies should be selected for those tumors.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    2010 Volume 56 Issue Suppl.1 Pages S25-S36
    Published: 2010
    Released on J-STAGE: November 01, 2011
    DOIhttps://doi.org/10.11334/jibi.56.S25
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese]
    2010 Volume 56 Issue Suppl.1 Pages S64-S65
    Published: 2010
    Released on J-STAGE: November 01, 2011
    DOIhttps://doi.org/10.11334/jibi.56.S64
    JOURNAL FREE ACCESS
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  • Rapid superselective high-dose cisplatin infusion with concomitant radiotherapy for hypopharyngeal cancer
    Akihiro HOMMA, Nobuhiko ORIDATE, Fumiyuki SUZUKI, Toshihiro HARA, Hiro ...
    2010 Volume 56 Issue Suppl.1 Pages S66-S70
    Published: 2010
    Released on J-STAGE: November 01, 2011
    DOIhttps://doi.org/10.11334/jibi.56.S66
    JOURNAL FREE ACCESS
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    The survival and functional outcome for hypopharyngeal cancer (HPC) still remains poor despite aggressive standard treatment involving debilitating surgery and postoperative radiation therapy. We reviewed our experience in the management of advanced HPC using rapid superselective high-dose cisplatin infusion with concomitant radiotherapy (RADPLAT) as organ preservation therapy. Twenty-one previously untreated patients with HPC were given superselective intra-arterial infusions of cisplatin (100-120 mg/m2/week) with simultaneous intravenous infusion of thiosulfate to neutralize cisplatin toxicity and conventional external beam radiotherapy from 2000 through January, 2009. During the median follow-up period of 43 months, the 5-year overall survival and local control rate were 42.8% and 77.8%, respectively. All patients with N0-1 (n=10) are alive wiyhout disease so far. However, the 5-year overall survival of patients with N2b-3(n=24) were 19%. It is not technically easy and sometimes dangerous to treat patients with HPC by intra-arterial chemotherapy. Recently, we consider that patients with T3-4a and N0-1, and primary tumor limited in one side are good candidate for RADPLAT.
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  • Transoral partial pharyngectomy using a distending laryngoscope with a rigid endoscope for hypopharyngeal cancer
    Yorihisa IMANISHI, Ryoichi FUJII, Seiji SHIGETOMI, Kuninori OOTSUKA, K ...
    2010 Volume 56 Issue Suppl.1 Pages S71-S80
    Published: 2010
    Released on J-STAGE: November 01, 2011
    DOIhttps://doi.org/10.11334/jibi.56.S71
    JOURNAL FREE ACCESS
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    We presented the surgical procedure and instrumentation customized for transoral partial pharyngectomy using a distending laryngoscope with a rigid endoscope, together with the preliminary treatment outcomes. This surgical setting provided a broad field of intraluminal view and a wide working space, facilitating bimanual direct handling and application of the ready-made straight-form surgical instruments including forceps for laryngomicro surgery and electric scalpel devices for laparoscopic surgery. Since April 2007 in our department, we have applied this procedure to transoral partial pharyngectomy for 25 patients with hypopharyngeal cancer staged at Tis, T1, T2,and selected T3 according to size criteria. Neck dissections were added to 14 patients with lymph node metastasis. The average period before oral alimentation was 2.2 days after surgery. All patients could regain their normal food intake. To date, local and regional lesions have been controlled in all patients, although the average period of follow-up was as short as 20 months. These preliminary results suggest that transoral partial pharyngectomy using aforementioned setting and instruments can be one of the less-invasive surgical options of laryngeal preservation strategy for hypopharyngeal cancer.
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  • Laryngeal preservation surgery of hypopharyngeal carcinoma
    Yoichi SEINO, ISHIDA Katsuhiro, Takakuni KATO
    2010 Volume 56 Issue Suppl.1 Pages S81-S88
    Published: 2010
    Released on J-STAGE: November 01, 2011
    DOIhttps://doi.org/10.11334/jibi.56.S81
    JOURNAL FREE ACCESS
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    In this retrospectives study, we reported on 16 patients with hypopharyngeal squamous-cell carcinoma who underwent hypopharynx partial excision at the Department of Otolaryngology, Jikei University Hospital between February 2005 and February 2009. Regarding postoperative staging, two patients were at stage I, 4 patients ; stage II, 3 patients ; III, and 7 patients ; stage IV A. 7 patients had a primary cancer lesion at the piriform sinus (PS). 3 patients had at the posterior wall (PW), one patient at the post-cricoid area (PC) and 2 patients between PS and PW. We performed hypopharynx partial excision and reconstruction with free flap for all patients to conserve larynx. No patients had any troubles with swallowing and phonation postoperatively. But, four patients relapsed in cervical lymph node and one patient relapsed in primary site. These patients were underwent current chemoradiation and 2 patients died of recurrence. The cause-specific 2-year survival rate by Kaplan-Meier was 84% in all patients and 63% in stage IV A. We underwent hypopharynx partial excision for a laryngeal preservation surgery and were able to keep patient's post-operative function of the swallowing and phonation at a good condition. Moreover, only one of 16 patients relapsed at primary site, and the cause-specific 2-year survival rate was as high as 84%. Therefore, these results suggest that hypopharynx partial excision is suitable for patients with hypopharyngeal squamous-cell carcinoma as surgery with conservation of larynx.
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    2010 Volume 56 Issue Suppl.1 Pages S89-S98
    Published: 2010
    Released on J-STAGE: November 01, 2011
    DOIhttps://doi.org/10.11334/jibi.56.S89
    JOURNAL FREE ACCESS
    Download PDF (625K)
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