We herein present the case of benign granular cell tumors (GCT) arising from the hypopharynx and the lower esophagus in a 29-year-old female. An excision under microlaryngoscopy witha CO
2 laser was performed on the lesion of the hypopharynx, and an endoscopic mucosal resection was performed on the lesion of the esophagus. The histopathologic study of the surgical specimens revealed the lesions to be GCTs. The postoperative course was uneventful. The patient has been asymptomatic without any evidence of recurrence after 6 months of postoperative observations. A resection under microlaryngoscopywith a CO
2 laser, when technically feasible, is a useful treatment for a GCT arising from the hypopharynx. To detect multiple lesions, especially esophageal lesions, upper gastrointestinal endoscopy should be performed. The patients who have undergone a surgical resection for a GCT should be followed up for at least 2 postoperative years to detect any recurrence.
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