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Volume 58, Issue 6
Displaying 1-7 of 7 articles from this issue
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Original Article
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Takehiro YUI, Hisayuki KATO, Tatsuyoshi OKADA, Kazuo SAKURAI, Naoki YA ...2012 Volume 58 Issue 6 Pages 255-260
Published: 2012
Released on J-STAGE: November 01, 2013
JOURNAL FREE ACCESSBackground : HPV-related oropharyngeal squamous cell carcinoma (OSCC) seems to be more responsive to chemotherapy and radiation than diseases unrelated to HPV. Therefore, it is accepted that HPV testing plays an important role as a biomarker in the management of patients with OSCC. Purpose: We aimed to find an optimal HPV detection algorithm using formalin-fixed paraffin embedded (FFPE) specimens. Methods: Archival biopsies from 68 patients with OSCC were evaluated. HPV DNA was detected by polymerase chain reaction (PCR) for HPV16, 18, 31, 35, 51, 52, 58, in situ hybridization (ISH) was performed for HPV16 or 18, and p16 was detected by immunohistochemistry (p16-IHC). Results : Of the 68 samples, HPV was positive in 25 by PCR (36.8%), 22 by ISH (32.4%), and p16 was overexpressed in 30 samples (44.1%). We defined that samples positive by more than two methods (PCR, ISH and/or p16-IHC) were HPV positive. The sensitivity, specificity, positive predictive value and negative predictive value were : 92%, 93%, 88% and 95% for PCR, 92%, 100%, 100% and 96% for ISH, 100%, and 86%, 80% and 100% for p16-IHC, respectively. Conclusion : We recommend that OSCC patients should undergo tumor evaluation for p16-IHC as a screening test and then HPV determination, preferably using an ISH assay.View full abstractDownload PDF (604K) -
Yutomo SEINO, Sanae OKABE, Tomoe MIYAZAKI, Tatsutoshi SUZUKI, Makito O ...2012 Volume 58 Issue 6 Pages 261-267
Published: 2012
Released on J-STAGE: November 01, 2013
JOURNAL FREE ACCESSA swallowing support team (SST), which is characterized by multidisciplinary cooperation between departments, was started at Kitasato University Hospital. The aim of the team was to evaluate the swallowing function, daily rehabilitation, etc., or patients with swallowing difficulty. In the seven months after establishing the SST, there were 120 consultations concerning 63 cases. Two or more investigators assessed each patient. The main primary diseases in the patients varied. There were 31 patients who had a past history of intubation and five with a tracheostoma. In the 49 cases who had final goals, 24 cases aimed for a discharge, and 21 cases aimed for a transfer to another hospital. Regarding oral intake, 18 cases were finally able to have oral intake in the group that aimed for a discharge, while in the other eight cases, this was impossible. Among the 30 patients who were provided total parenteral nutrition or enteral nutrition, we were finally able to offer oral intake in 21 cases. We forbade three patients from taking their diet orally because their swallowing dysfunction was deemed to be too severe. These patients who underwent intervention by SST needed to be assessed separately because they had various background disorders and severities of dysfunction. The plan could be immediately discussed at the bedside, and cooperation with the ward could be more easily obtained. Because of the short hospitalization period in this study, further studies should therefore be performed to fully clarify the usefulness of SST.View full abstractDownload PDF (981K) -
Chie OSHIKAWA, Reiko KISHIKAWA, Eiko KOTO, Nobuo SOU, Chizuko KAMORI, ...2012 Volume 58 Issue 6 Pages 268-277
Published: 2012
Released on J-STAGE: November 01, 2013
JOURNAL FREE ACCESSWe investigated the Cryptomeria japonica and Cupressaceae pollen count statistics for the 23-year period from 1988 to 2010 monitored at 17 locations in Fukuoka Prefecture. C. japonica and Cupressaceae pollen steadily increased, with a remarkable annual fluctuation. The average pollen count for the ten-year period from 2001 to 2010 was found to increase by 1.4-fold for C. japonica pollen and by 2.1-fold for Cupressaceae pollen in comparison to the ten-year period from 1988 to 1997. The increase in the Cupressaceae pollen was especially noteworthy. We compared the number of Japanease Cedar pollinosis patients consulting the otolaryngology and ophthalmology departments with the C. japonica and Cupressaceae pollen counts. The number of Japanease Cedar pollinosis patients was significantly associated with the pollen count, and therefore the pollen count is considered to be extremely useful medical information for pollinosis patients.View full abstractDownload PDF (2760K) -
Yoshifumi FUJITA, Kazumasa SUZUKI, Yoshiaki MORI, Ai KOMATSU, Takashi ...2012 Volume 58 Issue 6 Pages 278-284
Published: 2012
Released on J-STAGE: November 01, 2013
JOURNAL FREE ACCESSWe treated a case of intrathyroidal parathyroid adenoma which had not been detected by CT or ultrasonography, but was detected by 99mTc-sestamibi scintigraphy. The patient was a 72-year-old female who was diagnosed with diabetic nephropathy in 2003, and in 2011, was started on hemodialysis. In January 2012, she developed a femoral neck fracture and showed an increased value on Ca and intact-PTH. At the first examination, a right thyroid adenoma was pointed out by CT and ultrasonography, but parathyroid adenoma was not detected. However, during 99mTc-sestamibi scintigraphy, an increased accumulation of the radionuclide was seen in the right lobe of the thyroid gland. In March 2012, we performed a right thyroid lobectomy. A histological examination revealed an ectopic intrathyroidal parathyroid adenoma. Using non-invasive examinations, including CT, ultrasonography, and especially 99mTc-sestamibi scintigraphy, can provide important assistance in the diagnosis of an ectopic parathyroid gland.View full abstractDownload PDF (1661K) -
Shuji ISOGAWA, Ryuzo TORIYA, Fumiaki TANAKA, Takafumi TORIYA, Masatake ...2012 Volume 58 Issue 6 Pages 285-291
Published: 2012
Released on J-STAGE: November 01, 2013
JOURNAL FREE ACCESSThe mean cedar pollen count in Kumamoto Prefecture over the past 10 years has been approximately 2,000 grains/cm2. The leukotriene receptor antagonist (LTRA) montelukast was effective in the initial therapy for cedar pollinosis during the 2009 pollen season, when a massive dispersal of 4,289 grains/cm2 was observed. The present study applied the same initial therapy during the 2010 pollen season, which ultimately had a relatively low pollen count of 815 grains/cm2, and investigated whether the effectiveness of the initial therapy using montelukast varied depending on the level of cedar pollen dispersal. The subjects consisted of 82 patients with cedar pollinosis treated at one of 10 facilities in Kumamoto Prefecture between January and March 2010. Nasal symptoms were successfully controlled from the initiation of montelukast monotherapy to the end of the pollen season in a total of 54 patients (65.9%). This rate was higher than in 2009 (40.7%), thus suggesting that montelukast monotherapy had a higher rate of successful control of symptoms when the pollen count was low. In addition, an analysis of eight patients that received initial therapy using montelukast in both 2009 and 2010 showed that all four of the patients that responded in 2009 also responded in 2010, while three of the four patients that did not respond in 2009 also did not respond in 2010, when the pollen count was lower. These patients were thought to be “LTRA non-responders”, in other words patients for whom the effects of LTRA can not be expected regardless of the pollen count.View full abstractDownload PDF (643K) -
Michio TOMIYAMA2012 Volume 58 Issue 6 Pages 292-301
Published: 2012
Released on J-STAGE: November 01, 2013
JOURNAL FREE ACCESSThis study evaluated the efficacy and safety of a high-dose cefditoren pivoxil (CDTR-PI ; 6 mg/kg, t.i.d.) in 194 children that were diagnosed with severe acute rhinosinusitis according to “the 2010 Clinical Practice Guidelines for the Diagnosis and Treatment of Acute Rhinosinusitis” and had no response to clavulanic acid/amoxicillin ( 1 : 14 ; CVA/AMPC ⟨1 : 14⟩) therapy for 5 days. The rate of improvement obtained as a result of the administration of CDTR-PI to the children for 5 days was 91%. Two hundred eighty-eight pathogenic bacterial strains were isolated from purulent nasal discharge, Streptococcus pneumoniae (65 strains) and Haemophilus influenzae (169 strains) accounting for 82% of the total. The MIC90 of CDTR was 0.5μg/ml for both S. pneumoniae and H. influenzae. The pathogen was H. influenzae in all 17 of the cases that did not respond to the CDTR-PI treatment, and all of these cases were cured by the administration of azithromycin for 3 days and nasal aspiration daily. A dverse reactions to CDTR-PI included 21 cases of diarrhea (11%). In conclusion, the results support the efficacy of high-dose CDTR-PI for children with severe acute rhinosinusitis that do not respond to CVA/AMPC ( 1 : 14) therapy.View full abstractDownload PDF (865K)
Clinical Note
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[in Japanese]2012 Volume 58 Issue 6 Pages 302-304
Published: 2012
Released on J-STAGE: November 01, 2013
JOURNAL FREE ACCESSDownload PDF (2836K)
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