巻号一覧
29 巻, 6 号
選択された号の論文の7件中1～7を表示しています
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第2報BCG脱水素酵素に及ぼす影響に就いて山本 実1954 年 29 巻 6 号 p. 195-199
発行日: 1954年
公開日: 2011/05/24
ジャーナル フリーUsing the Thunberg's methylene blue decoloration method, the influence of INAH and its derivatives on the dehydrogenation of various substrates by BCG suspension were examined. Following results were obtained:
1. The inhibitory influence of INAH was observed in the dehydrogenation of lactic acid, malic acid, glucose, formic acid, ethyl alcohol, glutamic acid and pyruvic acid by BCG suspension, on the other hand, in case of histidine and succinic acid, it was not found.
2. The inhibitory influence of INAH on the dehydrogenation of lactic acid by BCG suspension was decreased to some extent by the addition of a large amount of cozymase.
3. The inhibitory influence of INAH on the dehydrogenation of various substrates by BCG resistant to 100 mcg/ml INAH was found to be remarkably weak.
4. N-isonicotinyl-N'-glucosyl hydrazine and N-isonicotinyl-N'-isopropyl hydrazine inhibited the dehydrogenation of various substrates by BCG suspension, however, they were weak compared with INAH.抄録全体を表示PDF形式でダウンロード (1060K) -
倉金 丘一, 高崎 秀雄1954 年 29 巻 6 号 p. 200-204
発行日: 1954年
公開日: 2011/05/24
ジャーナル フリーThe potency of 2 samples of the BCG purified tuberculin (BCGPT) obtained after Kurakane's (one of the authors) procedure, was investigated on 1399 persons who had not been vaccinated with BCG and 944 persons who had been vaccinated in comparison with the respective findings of the old tuberculin (0.1 ml of a 1: 2, 000 dilution) (OT) standardized by the National Institute of Health in Tokyo, and the following results were obtained抄録全体を表示PDF形式でダウンロード (1183K) -
その2結核アレルギーに関する実験的研究中村 滋, 小川 弥栄, 平山 稔, 高 啓一郎, 矢坂 茂, 山村 雄一1954 年 29 巻 6 号 p. 205-210
発行日: 1954年
公開日: 2011/05/24
ジャーナル フリーIn the 1st report, the method to produce the experimental tuberculous cavities in rabbit's lung which was successful in high percentage was reported. In this article, the pathohistologic findings of these cavities are reported.抄録全体を表示PDF形式でダウンロード (4508K) -
第1報2,000倍,10,000倍稀釈液を用いた前臆屈側と伸側との比較伊東 恒夫, 前田 道明, 柳沢 謙1954 年 29 巻 6 号 p. 211-215
発行日: 1954年
公開日: 2011/05/24
ジャーナル フリーVariability of tub3roulin reactions depending on the difference in the locality of the skin tested, has been already reported by many workers. Tuberculin reactions tested on the flexor surface and the extensor surface of the forearm were compared, for in our country the test has been made on the flexor surface while the workers of WHO advocate the other side.
Children of primary and secondary schools totaling 2, 448 were divided into two groups. One group received four injections of each 0.1 ml on the flexor and extensor surfaces of both forearms, the left with the 1: 2, 000 dilution and the right with the 1: 10, 000 dilution of OT. The other group was treated likewise except that the left side forearm received the 1: 10, 000 dilution and the right side 1: 2, 000 dilution of OT. Readings were made 48 hours later, the results of which were as follows:
1. The grade of positivity as well as the intensity of redness was better on the flexor surface than on the extensor surface on both left and right forearms and their distribution was also different.
2. The intensity and frequency of induration, on the contrary, were stronger and higher on the extensor surface than on the flexor surface on both forearms. There were 34.7% induration positive cases by 1: 2, 000 dilution on the extensor surface while the flexor surface showed no reaction.
3. The formation of double redness was also higher on the extensor surface than on the flexor surface.
4. Except some difference in intensity, the reactions responded to the 1: 10, 000 dilution of OT were of the same tendency.抄録全体を表示PDF形式でダウンロード (914K) -
関根 修1954 年 29 巻 6 号 p. 216-220
発行日: 1954年
公開日: 2011/05/24
ジャーナル フリーAdvantage in the use of supersonic wave as a homogenizer for the preparation of BCG vaccine lies in the relative easiness of producing a large quantity of concentrated emulsion with good dispersibility of the bacilli in a rather short time.抄録全体を表示PDF形式でダウンロード (1164K) -
橋本 達一郎, 吉田 幸之助1954 年 29 巻 6 号 p. 221-224
発行日: 1954年
公開日: 2011/05/24
ジャーナル フリーSince the standard strains of human type of tubercle bacilli are not always constant in their viru lence, the experimental studies on their virulence often encounter with great dfficulties. In order to analyse the factors influencing on their virulence, guinea pigs were inoculated with H2 or H37Rv subcu taneously and autopsy findings were examined.
The results revealed that it was impossible to estimate the degree of their virulence from the standpoint of the size of inoculum (semidry weight or viable units) or culture days etc., because of the unexpected qualitative variations in their virulence in every generation cultivated on potato-media. The instability in their virulence may due to the irregular variation in the population of lowly virulent mutants influenced by some unknown conditions.
As a practical method adequate for the stabilization or their virulence, therefore, freeze-drying procedure was adopted which enabled to fix the population of highly virulent bacilli. Guinea pig inoculation showed that these freeze-dried strains maintained their virulence fairly well being unchang ed even 10 months after drying. This freeze-drying method made it possible to undertake animal experiments with virulent bacilli of known virulence and viable units.抄録全体を表示PDF形式でダウンロード (1031K) -
本橋 政男1954 年 29 巻 6 号 p. 225-231
発行日: 1954年
公開日: 2011/05/24
ジャーナル フリーNasal mucosa is always exposed to the danger of the invasion of microorganisms as the opening of respiratory system, therefore, it is very much likely that this part of the body might possess some particular function which would prevent the invasion of pathogenic agents such as tubercle bacilli. As it was not practicable to inoculate virulent tubercle bacilli into human nasal mucosa, tuberculin injection was made into the nasal mucosa and the reactions produced were examined pathohistologically in order to know some aspect of such defensive function.抄録全体を表示PDF形式でダウンロード (1697K)
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