巻号一覧
70 巻, 4 号
選択された号の論文の7件中1～7を表示しています
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小松 彦太郎, 永井 英明, 佐藤 紘二, 倉島 篤行, 宍戸 春美, 町田 和子, 川辺 芳子, 赤川 志のぶ, 大塚 義郎, 長山 直弘 ...1995 年 70 巻 4 号 p. 281-284
発行日: 1995/04/15
公開日: 2011/05/24
ジャーナル フリーThe association of pulmonary tuberculosis and bronchogenic carcinoma has beenreported by many authors, however, there are rather few studies about the association ofpulmonary tuberculosis and other malignant diseases and how the latter affects theoutcome of the former.
Between 1980 and 1993, we had in our hospital 104 patients who had both activepulmonary tuberculosis and malignant diseases. Pulmonary tuberculosis was diagnosed at the time or after the diagnosis of malignant diseases in 74 patients, of whom 92% (68patients) were males and 42% (31 patients) were over the age of 70. There were 23 stomachcancer (31%), and 15 lung cancer (20%). In 11 patients tuberculosis developed after theinitiation of radiation and/or chemotherapy. 67 patients could be followed up for morethan 6 months after the initiation of chemotherapy for tuberculosis and the negativeconversion rate was as high as 95.5% at 3 months.
The fact indicates that the association of malignant diseases dose not influence thecourse of tuberculosis and that these patients could be treated safely in general hospitals, provided the diagnosis is made properly without unnecessary delay.抄録全体を表示PDF形式でダウンロード (497K) -
鈴木 秀和, 斎藤 肇, 佐藤 勝昌, 冨岡 治明1995 年 70 巻 4 号 p. 285-292
発行日: 1995/04/15
公開日: 2011/05/24
ジャーナル フリーJTP3309, a newly synthesized lipid A-subunit analogue, was examined for in vitro andin vivo antimycobacterial activities. Firstly, the effect of JTP3309 on the in vitro antimycobacterial activity of murine peritoneal macrophages (Mos) was studied. When residentperitoneal MOs from CBA mice which had phagocytosed Mycobacterium avium were treated with JTP3309 once from 0 hr to 24hr after the initiation of MOs cultivation or three timesfrom 0 hr to 24hr, 48hr to 72hr and 96hr to 120hr of culture period, there was no increasein the anti-M. avium activity of the treated MOs. On the other hand, the bacterial growthwas slightly inhibited in peritoneal MOs from mice which had been injected with JTP 3309, in comparison with that seen in resident MOs. Secondly, protective and therapeuticefficacies of JTP3309 against M. avium and M. fortuitum infections in mice were studied, based on the suppression of the bacterial growth in the visceral organs including the lungs, kidneys and spleen. BALB/c mice infected i. v. with M. avium were given JTP3309 i. v. at thedoses of 10 and 20μg/mouse according to the following protocols; protocol A, twoinjections 4 and 1 day (s) before the infection; protocol B, once daily at days 1, 3, 5, 12, 19, 26, 33, 40, 47 and 54 after the infection; protocol C, once daily at days 1, 8, 15, 22, 29, 36, 43 and 50 after the infection. Only protocol A could reduce the number of CFU recoveredfrom the spleen of infected mice. A/J mice infected i. v. with M. fortuitum were givenJTP3309 i. v. at doses of 10 and 20-Eg/mouse, in the same administration schedules as aboveexcept for mice killed on day 28. Only mice given JTP3309 in the protocol A were protectedfrom the death and the number of CFU recovered from their spleen on day 28 weresignificantly reduced. These results show that JTP3309 possesses protective but nottherapeutic activity against M. avium or M. fortuitum infection.抄録全体を表示PDF形式でダウンロード (983K) -
照屋 勝治, 川上 和義, 當山 雅樹, 斎藤 厚1995 年 70 巻 4 号 p. 293-299
発行日: 1995/04/15
公開日: 2011/05/24
ジャーナル フリーThe present study was performed in order to define the responding populations andprofiles of cytokine production in BCG-primed spleen cells restimulated in vitro withantigen. Spleen cells from DBA/2 mice, one of BCG-resistant strains (Bcgr), infected with Mycobacterium bovis BCG vigorously proliferated by restimulation with heat-killed BCG.
This response peaked as early as on day 3 after BCG infection, and then decreased to thebasal level by 3 weeks. Blocking of IL-2Ra chain or IL-4 by each antibody partiallyinhibited it, but anti-IFN-A antibody did not, suggesting that both IL-2 and IL-4 wereinvolved in the proliferation of primed spleen cells. CD4+and A TCR-bearing T cell wereresponding populations to BCG, but CD8+T cell was not, because depletion of CD4+ or A Tcells by the treatment with each antibody and complement inhibited proliferation and IL-2/IL-4 production, but that of CD8+ T cells did not. Further study demonstrated that spleencells from BCG-resistant DBA/2 mice produced more IL-2/IL-4 than those from BALB/cmice, one of BCG-susceptible strains (Bcgs), in response to BCG.
These results suggest that both CD4+and ATCR-bearing T cells play an importantrole in the host defense against M. bovis BCG infection, and that the magnitude of cytokineproduction is one of the critical factors to define the susceptibility of mice to this pathogenin the late phase of infection.抄録全体を表示PDF形式でダウンロード (937K) -
松本 建志, 上田 眞太郎, 堀江 孝至1995 年 70 巻 4 号 p. 301-305
発行日: 1995/04/15
公開日: 2011/05/24
ジャーナル フリーA case of pulmonary tuberculosis complicated with tuberculous of oral mucosa, mandible and cervical lymph nodes in 53-year-old man is reported. He was firstly treatedfor right side dental caries. He also received routinely an empiric antibiotic therapy, butdischarge of pus continued. Then, pain of oral cavities spread to the right shoulder. Thediagnosis of oral mucosa, osteomyelitis of mandible and lymph node tuberculosis was madeby the histological examination of biopsy specimens and positive smear test for M. tuberculosis in granulation. The chest X-ray film showed multiple nodular shadows inbilateral lungs.
The combination of INH, RFP and SM was applied initially and then SM was replacedby CS due to its side effect. Negative smear test for M. tuberculosis of oral mucosa wasachieved five months after the initiation of treatment.抄録全体を表示PDF形式でダウンロード (1448K) -
小笠原 智彦, 千田 嘉博, 戸谷 康信, 鈴木 雅之, 大鹿 裕幸, 前田 浩義, 服部 典子, 阿部 知司1995 年 70 巻 4 号 p. 307-311
発行日: 1995/04/15
公開日: 2011/05/24
ジャーナル フリーA case of pulmonary tuberculosis manifested as infected bulla complicating withtuberculous pneumonia is reported. A 63-year-old male visited our hospital because ofchest X-ray abnormality detected by his home doctor. He complained of pyrexia andproductive cough. Chest X-ray showed large bulla with air-fluid level, associated withsurrounding infiltration at right upper lobe. On the diagnosis of infected bulla empiricalantibiotic therapy was started on out-patient basis and continued after admission, butchest X-ray findings worsened, although subjective symptoms were once relieved. Surgicalintervention was recommended, but after short interval pulmonary infiltrates rapidlyworsened and expanded to other lobes. Sputum was reexamined and Mycobacterium, laterproved as Mycobacterium tuberculosis with DNA probe method, was detected in the sputumspecimen. Anti-mycobacterial drugs were administered and subjective symptoms, laboratory, and chest X-ray findings improved.
Infected bulla caused by Mycobacterium tuberculosis is rare, but when it is resistant tocommon empirical therapy, Mycobacterium tuberculosis should be considered as one of itscausative agents.抄録全体を表示PDF形式でダウンロード (1094K) -
Richard E. Chaisson1995 年 70 巻 4 号 p. 313-320
発行日: 1995/04/15
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (1027K) -
1995 年 70 巻 4 号 p. 331-333
発行日: 1995/04/15
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (315K)
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