巻号一覧
49 巻, 11 号
選択された号の論文の11件中1～11を表示しています
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砂原 茂一1974 年 49 巻 11 号 p. 357-358
発行日: 1974/11/15
公開日: 2011/05/24
ジャーナル フリーIn accordance with the rapid decrease in tuberculosis mortality and prevalence, it seems that research workers in tuberculosis and the Japanese Society for Tuberculosis itself has been losing their self-confidence, though they should have been very much proud of the success in tuberculosis control. Does marked reduction in the prevalence of disease due to advances in disease research necessarily bring about unconcern in the research itself ?抄録全体を表示PDF形式でダウンロード (356K) -
1.細菌学・免疫学の立場から武谷 健二1974 年 49 巻 11 号 p. 359-362
発行日: 1974/11/15
公開日: 2011/05/24
ジャーナル フリーFuture aspects based on the present progress in the field of bacteriology and immunology of tuberculosis were presented. From the parasite-side, problems of classification and nomenclature of mycobacteria and those of bacteriocin-typing of human type tubercule bacilli were discussed. From the host-side, problems of the nature of protective immunity to tuberculosis, those of immune-response gene in tuberculosis, those of immune deviation-like phenomenon as known in leprosy and the those of BCG treatment of tumors were discussed.抄録全体を表示PDF形式でダウンロード (808K) -
2.化学の立場から山村 雄一1974 年 49 巻 11 号 p. 363-366
発行日: 1974/11/15
公開日: 2011/05/24
ジャーナル フリーSeveral important problems in biochemical and immunochemical standpoint of view were reviewed.
It was emphasized that Mycobacterium and related micro-organisms will become one of the most important materials for the study of immunological problems, such as adjuvanticity, stimulation of T-cell activity, delayed type hypersensitivity and tumor immunotherapy in the future.
Researchers in tuberculosis should have their interests not only for the disease due to tubercle bacilli but also for broad field of immunology.抄録全体を表示PDF形式でダウンロード (990K) -
3.結核対策の実際に関連した分野岩崎 龍郎1974 年 49 巻 11 号 p. 367-370
発行日: 1974/11/15
公開日: 2011/05/24
ジャーナル フリーThe eradication of tuberculosis is now technically possible by utilizing existing measures for the control of tuberculosis. The problem is have to promote adequate implementation of the measures, that is, operational difficulties. In this respect the operational research in different fields of tuberculosis control programme is urgent to find out suitable way for Japanese situation.
Of course it is necessary as before to promote basic as well as clinical researches i n tuberculosis, because the development of new technique often solves the operational difficulties.
It is also important to find out useful results from studies of the past, whic h were carried out only from academic interests but very useful at present from practical stand point.
Tuberculosis is still an important public health problem of the world, especially in developing countries. Japan is in the situation to cooperate with these countries in the control of tuberculosis, so in the field of research in tuberculosis, the practical implementation of the control programme of these countries should be also taken into consideration.
From these principles the following problems in the c ontrol of tuberculosis were discussed; epidemiological index of tuberculosis, method of surveillance of tuberculosis, vaccination of tuberculosis, research on tubercle bacilli including bacteriological examination of clinical material, factors of breakdown of tuberculosis, method of screening of risk group, diagnosis of activity of tuberculosis, supervision in chemotherapy, shortening of the duration of chemotherapy and development of antituberculous drugs especially effective on tubercle bacilli of resting state, etc.抄録全体を表示PDF形式でダウンロード (1004K) -
志摩 清, 安藤 正幸, 樋口 定信, 福田 安嗣, 徳臣 晴比古1974 年 49 巻 11 号 p. 371-374
発行日: 1974/11/15
公開日: 2011/05/24
ジャーナル フリー0.4 ml of an emulsion containing 25 mg of 2% phenolized BCG per milliliter was prepared with equal amount of steril saline and incomplete Freund adjuvant.0.1 ml of its portions were injected into all four foot-pads of the guinea pigs. From the same day of the above immunization, Rifampicin (RFP) 100 mg/kg in propylenglycol (propy. ) was injected into the muscle of guinea pigs daily for 16 days and the saline or propylenglycol alone was injected as the control. Tuberculin testing (old tuberculin diluted 1: 10) was done 12 days and 16 days after immunization and the intensity of the reaction was expressed as a volume of the reaction by multiplying the reaction area with thickness. A volume of tuberculin reaction in the RFP, propy. and saline groups is 223.8±49.2 mm3, 1, 367.6±202.6 mm3 and 1, 428±197.6 mm3, respectively, and supressive effect on tuberculin reaction by RFP was observed obviously. (Table 1)抄録全体を表示PDF形式でダウンロード (691K) -
長井 苑子, 泉 孝英1974 年 49 巻 11 号 p. 375-382
発行日: 1974/11/15
公開日: 2011/05/24
ジャーナル フリーRifampicin (RFP) is one of the active antibiotics for the treatment of pulmonary tuberculosis, and at the same time, very interesting agent for biochemical research including RNA synthesis, immunosuppressive effect, antitumor effect and anti-allergic effect, and etc.
Although some data show that RFP has immunosuppressive effect on hum o ral and cellular immune reactions in vivo and in vitro, the mechanism of this action of RFP, especially problems about target cell of RFP, has remained obscure.
It is most important to study whether the immunosuppressive effect of RFP is advantageous or not in the treatment of patients and how therapeutic doses of RFP effect on immunological status in patients.
From the above stand points, tuberculin hypersensitivity, lymphocyte counts, T lymphocyte counts and serum γ-globulin were examined on 20 patients treated with therapeutic dose of RFP and the results were compared with the controls treated with other antituberculous drugs.
The results show that: (1) Significant decrease of tuberculin hypersensitivity and T lymphocyte counts were observed at 2 and 4 weeks after administration of RFP in the most of cases but this decrease was recovered after 8 weeks. (2) Lymphocyte counts and serum γ-globulin were not affected.
From the above results, it is suggested that T-lymphocyte may be one of the target cell of RFP but the interference of RFP on immunological status of patients was transient and reversible.抄録全体を表示PDF形式でダウンロード (1350K) -
大平 一郎, 児島 靖, 金子 秀夫, 高橋 吉彦, 中村 剛, 公文 通夫, 松永 篤, 高橋 斉夫1974 年 49 巻 11 号 p. 383-386
発行日: 1974/11/15
公開日: 2011/05/24
ジャーナル フリーFor 73 patients with pulmonary tuberculosis, who were admitted to Jikei Hospital during past 3 years since May 1971, the acid-base balance in venous blood samples as well as BSR, bacteriological examination of sputum, urinalysis and others, was measured once a month as a routine laboratory examination.
This procedure is relatively simple and could be repeated easily.
In these patients various complications were observed. Such as 3 cases of diabetes melitus, 1 case of renal acidosis, 1 case of hyperventilation syndrome and 3 cases of respiratory failure, and these complications were effectively detected and treated by means of acid-base balance measurement.
Furthermore, course of pulmonary dysfunction accompanied with pulmonary tuberculosis, could be generally presumed by measuring the mode of changes of the carbon dioxide tension in blood caused by various grades of respiratory dysfunction.
These results suggest that the acid-base balan c e measurement is a valuable tool for the treatment of hospitarized patients with pulmonary tuberculosis, especially cases with pulmonary dysfunction.抄録全体を表示PDF形式でダウンロード (726K) -
亀田 和彦, 木野 智慧光1974 年 49 巻 11 号 p. 387-391
発行日: 1974/11/15
公開日: 2011/05/24
ジャーナル フリーThis is a preliminary report on the trial of shortening the duration of chemotherapy for previously untreated cases with pulmonary tuberculosis, and the study was started in March, 1973. All cases were bacteriologically positive for tubercle bacilli and had cavity at the start of the treatment. They were 15 years or more in age and agreed to stay in the hospital at least for the first 6 months and to attend the outpatient department of the hospital after discharge.抄録全体を表示PDF形式でダウンロード (986K) -
堀江 和夫, 田島 玄, 野中 拓之, 鵜沢 毅1974 年 49 巻 11 号 p. 393-398
発行日: 1974/11/15
公開日: 2011/05/24
ジャーナル フリーA quarter of century has passed since the discovery of cortisone, and various derivatives with higher potency and less side-effects have been found and applied in the wide range of diseases, but the antiinflammatory and immuno-suppressive effects of the drug were not separable. Many papers which have been published so far, reported on one hand, the beneficial effect of steroids used as the adjunct therapy with chemotherapy in tuberculosis, on the other hand, acute exacerbation of latent tuberculosis induced by steroids currently used in various diseases.
In this report we have aimed at the reevaluation of steroids in the treatment of tuberculosis. Eleven cases of miliary tuberculosis, five cases of meningeal tuberculosis, of which three were found associated with miliary tuberculosis and two with pulmonary tuberculosis, and 80cases of tuberculous pleurisy admitted into our hospital during the period of fifteen years from 1957 to 1971 were studied. One case of meningeal tuberculosis seems to have been induced by steroids.
All cases of miliary and meningeal tuberculosis have survived without sequelae by using steroids as the adjunct therapy. As regards tuberculous pleurisy, a comparative study of 61cases treated by chemotherapy with steroids and 19 cases treated by chemotherapy alone has been made. Statistically no significant difference has been found in the residual pleural adhesion contrary to our expectation. Out of cases treated by chemotherapy with steroids rebound phenomenon occurred in 15 cases and three cases presented reactivation of latent tuberculosis as against none from those treated by chemotherapy alone.
In summary, as being a double-edged sword, the place of steroids in the treatment of tuberculosis should be limited. For meningeal tuberculosis the steroids have a definite indication to suppress the fatal blocking of spinal. Canal miliary tuberculosis itself can be cured by chemotherapy alone but steroids should preferably be used to avoid meningeal complication. However it would be useless to administer steroids systematically in the cases of tuberculous pleurisy except its limited use in relieving severe symptoms.抄録全体を表示PDF形式でダウンロード (1214K) -
堀 三津夫, 山本 正彦1974 年 49 巻 11 号 p. 399-401
発行日: 1974/11/15
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (563K) -
1974 年 49 巻 11 号 p. 402
発行日: 1974年
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (143K)
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