巻号一覧
64 巻, 6 号
選択された号の論文の7件中1～7を表示しています
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Sulfadimethoxineと他抗結核剤との併用効果束村 道雄1989 年 64 巻 6 号 p. 379-386
発行日: 1989/06/15
公開日: 2011/05/24
ジャーナル フリーPreviously the author observed that sulfadimethoxine is most effective among sulfa drugs against Mycobacterium avium complex strains (Tsukamura, M.: Kekkaku 58: 247-250, 1983) and used this drug in the treatment of pulmonary infection caused by M. avium complex (Tsukamura, M.: Kekkaku 59: 33-37, 1983). In the present study, some supplemental observations were carried out on the in vitro activity of this drug. In vitrosusceptibility testing of sulfadimethoxine by the use of Ogawa egg medium was influenced by the number of viable bacteria (colony-orming units) used in the susceptibility testing (Table 1).By the use of small inocula (50 to 100 colony-forming units), minimal inhibitory concentration (MIC) was determined as 0.8 to 3.13μg/ml, whereas, by the use of large inocula, the MIC was determined as 6.25 to 25μg/ml. Furthermore, the prolongation of incubation time resulted in the elevatien of the MIC (Tables 1 and 2). The finding shows that the activity of this drug is only to delay the growth. Comparing various combinations with low concentrations of other drugs, combinations with p-aminosalicylate, isoniazid and pyrazinamide seemed to be antagonistic, and combinations with the other drugs seemed to be additive (Table 2).
The influence of the inoculation size on the reading of MICs were compared in Mycobacterium tuberculosis and M. avium complex strains (Table 3 and 4). The susceptibility testings to most drugs were influenced by the inoculation size. However, the testings to ethionamide, ethambutol and isoniazid in M.tuberculosis strains were less influenced by the inoculation size. In contrast, the susceptibility testings to ethionamide and isoniazid in M. avium complex strains seemed to be more influenced. It is suggested that this difference is due to a difference in the mode of action of drugs between these two organisms.抄録全体を表示PDF形式でダウンロード (904K) -
源馬 均, 佐藤 篤彦1989 年 64 巻 6 号 p. 387-399
発行日: 1989/06/15
公開日: 2011/05/24
ジャーナル フリーThe effect of glucocorticoid on the immunological response in the delayed type hypersensitivity reaction of granulomatous disorders was investigated in order to elucidate the mechanism of glucocorticoid on the suppressive course of the reaction.
Experimental pulmonary granuloma model in rats was induced by an intravenous injection of heat killed BCG, and the effects of methylprednisolone (MPSL) on the granulomatous lung tissue, bronchus associated lymphoid tissue (BALT) and the population of cells from bronchoalveolar lavage fluid (BALF) and peripheral blood were examined by the cytological and immunohistochemical methods.
The pulmonary granulomatous reaction was reduced effectively by the administration of MPSL.A remarkable reduction of the number of Ia antigen positive alveolar macrophages (Ia+A·Mφ) and T lymphocytes in the granulomatous lung tissue and BALF was observed. Thelper cells to non-helper cells (TH/TNH) ratio in BALF decreased remarkably.Furthermore, a reduction of Ia antigen positive macrophages (Ia+Mφ) and T cells was noted in the parafollicular area of BALT. These findings suggest that glucocorticoid may suppress the immunological activity of Mφ and T cell through its inhibitory effect on the differentiation of Ia+Mφ and activated T cells, which may result in the diminishment of pulmonary granulomatous reaction through the disorder of Mφ-T cell interaction.
On the other hand, lymphocytopenia with decreased TH/TNH ratios in peripheral blood was observed simultaneously with the reduction of the pulmonary granulomatous reaction. Thus, the mechanism of reduced pulmonary granulomatous reaction after MPSL administration may be not only due to local immunosuppression, but also to impaired systemic immune response.
In addition, the disappearance of the germinal center and the reduction of surface IgM-positive cells in the follicular area of BALT occured with the reduction of pulmonary granulomtous reaction.These results suggest that glucocorticoid also suppress the humoral immune responses in BALT during the course of delayed type hypersensitivity reaction.抄録全体を表示PDF形式でダウンロード (8410K) -
特にその菌体表層に表現されているリガンドの性状冨岡 治明, 斎藤 肇, 佐藤 勝昌, 山本 由香里, 内田 方子, 山田 義貴1989 年 64 巻 6 号 p. 401-406
発行日: 1989/06/15
公開日: 2011/05/24
ジャーナル フリーThe two types of colonial variants of Mycobacterium avium complex, SmT (smooth, transparent, irregular) and SmD (smooth, opaque, dome-shaped) variants, were examined for their triggering activity for macrophage (Mφ) respiratory burst, based on chemiluminescence (CL). SmD variants elicited an intense CL from zymosan A-induced Mφs in a dose-dependent manner, although SmT variants induced much lower Mφ CL. The Mφs could steadily phagocytose SmT variants, although the phagocytizing rate was considerably lower compared to the case of SmD variants.Treatments of SmD variants with Tween 80, pronase and some endoglycosidases such as a-amylase, cellulase, dextranase and pectinase, heating (100°C, 15 min), and delipidation by CHCl3-methanol extraction resulted in a marked reduction in the Mφ CL-triggering activity of the SmD variants. Thus, the Mφ CL-triggering ligand (s) seems to possess glycolipoprotein-like moieties. Tween 80-treatment of SmT variants, which is known to deprive the polysaccharide outer layer specific to the colonial variants, failed to recover the Mφ CL-triggering activity of SmT variants.Therefore, the remarkably reduced MφCL-triggering ability of the SmT variants may be caused by the extremely lowered expression of the Mφ CL-triggering ligands rather than by masking of the CL-triggering ligands by SmT-specific outer layer.抄録全体を表示PDF形式でダウンロード (571K) -
矢木 晋, 守屋 修, 中島 正光, 梅木 茂宣, 日野 二郎, 副島 林造1989 年 64 巻 6 号 p. 407-412
発行日: 1989/06/15
公開日: 2011/05/24
ジャーナル フリーA case of tuberculous pleurisy associated with myoclonus and Quincke's edema due to isoniazid (INH) and isoniazid sodium methanesulfonate (IHMS) was reported.
A75-ear-old man was admitted to our division because of chest discomfort and the left chest pain of one month's duration. A conventional chest rentgenogram revealed pleural effusion in the left thoracic cavity. The pleural specimen obtained from the left parietal pleura revealed caseating granuloma. Myoclonus suddenly appeared two months after the administration of antituberculous drugs for tuberculous pleurisy. Therefore, INH was discontinued. Three days later the patient's myoclonus disappeared and nine days later IHMS was newly administered. The patient abruptly developed myoclonus and Quincke's edema. IHMS was discontinued and 30 mg of prednisolone was simultaneously given. Two days later myoclonus disappered and two days more later Quincke's edema was improved. The lymphocyte stimulation test using IHMS was positive. At that time, levels of serum vitamin B6 were within normal levels. These results suggest that myoclonus may result from epileptogenic action caused by INH or IHMS, and Quincke's edema may result from hypersensitive reaction associated with IHMS.抄録全体を表示PDF形式でダウンロード (1544K) -
菅原 斉, 平沢 邦彦, 吉岡 礼, 與沢 宏一, 舘田 邦彦, 柴田 淳一, 池田 裕次, 坂井 英一, 大崎 能伸, 小野寺 壮吉1989 年 64 巻 6 号 p. 413-419
発行日: 1989/06/15
公開日: 2011/05/24
ジャーナル フリーTwo cases of miliary tuberculosis with syndrome of inappropriate secretion of antidiuretic hormone (SIADH) were reported. Case1. A 70-year-old woman suffering from general fatigue and appetite loss developed neck stiffness and stupor three days after admission. The chest X-ray film showed a miliary pattern in both lungs. The lumber puncture showed high pressure and increased leucocytes in the cerebrospinal fluid. Serum natrium concentration was 113mEq/L. Tubercle bacilli were seen in the broncho-lveolar lavage fluid by the Ziehl-ielsen staining.An improvement in electrolytes balance was produced by 2.5%NaCl and antituberculous treatment, then her mental function recovered. Case 2.A 71-year-old man was admitted with gastric ulcer. When he developed dry cough thirty days after admission, the chest X-yay film showed a miliary pattern in both lungs. Acute respiratory failure advanced concomitantly. Tubercle bacilli were seen in the sputum (Gaffky 5) by the Ziehl-Nielsen staining. Antituberculous treatment was started. Although the miliary shadow improved gradually, hyponatremia was rather progressing. The following values for serum constituents were determined: sodium, 118 mEq/L; antidiuretic hormone, 10.3pg/ml. Antituberculous treatment and supplement of NaCl (10 g/day) mproved serum natrium level. He had no mental diasturbance in his clinical course.
In both cases, thyroid, renal and adrenal function were normal. Systemic edema and dehydration did not exist at the state of hyponatremia, and it was very clear that laboratory data were compatible with SIADH criteria. Miliary tuberculosis is one of the least commonly recognized causes of SIADH.抄録全体を表示PDF形式でダウンロード (3299K) -
厚生省保健医療局長1989 年 64 巻 6 号 p. 445-449
発行日: 1989/06/15
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (451K) -
厚生省保健医療局結核・感染症対策室編1989 年 64 巻 6 号 p. 451-452
発行日: 1989/06/15
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (244K)
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