巻号一覧
54 巻, 8 号
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片岡 哲朗, 徳永 徹1979 年 54 巻 8 号 p. 413-417
発行日: 1979/08/15
公開日: 2011/05/24
ジャーナル フリーBCG-sensitized guinea pigs were injected intradermally (id) with either 2μg PPD alone, 2-0.02μg PPD plus 100μg bovine serum albumin (BSA), or 100μg BSA alone. Two weeks later, the animals were skin-tested with 5μg BSA. Positive delayed-type hypersensitivity (DTH) skin reactions to BSA sized more than 10mm in diameter were observed only in the animals which were injected id with PPD plus BSA (Table 1). When 1 ug of bovine gamma globulin (BGG) was used instead of BSA, similar adjuvant effect of DTH to PPD on the induction of DTH to BGG was observed (Table 4). Arthus-type skin reaction had never been demonstrated. The DTH reactions induced were antigen-specific.
By the similar way, the adjuvant effect of DTH skin reaction to BGG was also tested; normal guinea pigs were sensitized with subcutaneous injection of 1mg BGG mixed with Freund's complete adjuvant, and challenged with 5μg BGG plus 100μg BSA 3 weeks later. Three weeks after the challenge, these animals were skin-tested with 5pg BSA. Although significant level of DTH to BGG was developed in these animals, no positive reaction to BSA was detected (Table 3).
Normal guinea pigs were injected id with crude lymphokines, obtained as a culture supernatant of spleen cells of a BCG-sensitized guinea pig mixed with PPD, plus 100μg BSA, and skin-tested with 5μg BSA 3 weeks later; no DTH to BSA was observed (Table 2). It is suggested that so-called tuberculin-type reaction, but not Jones-Mote-type reaction, is required for the adjuvant effect of DTH on the induction of the DTH to an unrelated antigen located at the site of the former DTH.
The intensity of DTH reaction to PPD seemed to affect the induction of DTH to BSA or BGG; in the BCG-sensitized guinea pigs challenged with 2μg PPD plus 100μg BSA, or 2μg PPD plus 1μg BGG, 3 of 5 animals and none of 5 developed DTH to BSA or BGG, respectively, whereas all of the animals challenged with 0.02μg PPD plus 100μg BSA, or 3 of 5 challenged with 0.02μg PPD plus 1μg BGG showed positive DTH reactions to BSA or BGG, respectively (Table 4). The sizes of the DTH reactions induced were larger in the latter group than in the former group (Table 4). It is possible that too vigorous inflamatory response to PPD reduce the adjuvant effect on induction of DTH to protein antigens.抄録全体を表示PDF形式でダウンロード (795K) -
M. M. Abdel KADER, M. S. Kawther, S. SHOUB, B. A. El-MOURSI, F. HALAWA1979 年 54 巻 8 号 p. 419-421
発行日: 1979/08/15
公開日: 2011/05/24
ジャーナル フリーHistidine was shown to have a potent anti-tuberculous action in vitro and in vivo. The antituberculous effect of some histidine derivatives were further tested, in vitro. Of these derivatives, imidazole and histamine presented high potency in their antituberculous action in vitro. The in vivo effect of imidazole was subsequently investigated.
This investigation was further conducted to study the in vivo action of histamine in guinea-pigs, in order to compare it with those previously shown by histidine and imidazole.抄録全体を表示PDF形式でダウンロード (486K) -
内藤 祐子, 久世 文幸, 前川 暢夫1979 年 54 巻 8 号 p. 423-427
発行日: 1979/08/15
公開日: 2011/05/24
ジャーナル フリーThe sensitivities of fifteen disease-associated strains of M. intracellulare were tested in vitro using Dubos Tween Albumin liquid medium to ten aminoglycoside and three peptide antibiotics. The drugs tested were SM, KM, DKB (Dideoxykanamycin B), AKM (Aminodeoxykanamycin), AMK (Amikacin), AMD (paromomycin), GM (Gentamicin), VSM (Ribostamycin), LVM (Lividomycin), TOB (Tobramycin), EVM (Enviomycin), CPRM (Capreomycin) and VM.
The strains isolated from the patients in our Institute, seven of the fifteen strains tested, showed low sensitivities against all drugs tested. The growth of only one strain each was inhibited by TOB, GM, VSM and AMK at the concentrations less than 1.56μg/ml. The results obtained here were not encouraging for clinical trial.
The remaining eight strains tested, which were TMC (Trudeau Mycobacterial Culture Collection) strains, which were kindly provided by the U. S.-Japan Cooperative Medical Science Program-NIAID in 1975, showed considerable sensitivities to all aminoglycoside antibiotics tested, though the sensitivities to peptide antibiotics were not impressive.
The pattern of the sensitivities to these antibiotics was similar in the U. S. strains and in Japanese strains, except SM exhibited more potent activities against U. S. strains than Japanese strains. TOB and GM showed the most potent activity to M. intracellulare among the drugs tested, and the least activities were exhibited by VM, CPRM and EVM, which were all peptide antibiotics. The remaining aminoglycosides were in between the two groups of the drugs in their activities against M. intracellulare.
The overall differences of sensitivity between U. S. strains and Japanese strains were not readily explanatory.抄録全体を表示PDF形式でダウンロード (652K) -
患者登録後3年目の実態と患者発生亀田 和彦, 久池 井暢, 堀井 富士子, 大塚 順子, 佐藤 寿美子, 畑田 一憲, 影山 テル1979 年 54 巻 8 号 p. 429-433
発行日: 1979/08/15
公開日: 2011/05/24
ジャーナル フリーAs mentioned in the author's previous reports, the detection rate of new tuberculosis patients was high among family contacts of newly registered pulmonary tuberculosis patients. The survey on the family contacts examination was repeated in the third year after the registration of index cases in the same way as in the first and second years.
Out of 815 patients newly registered at 12 health centres of Osaka Prefecture during the period from January to June, 1976, 179 were omitted from the registry up to the end of October, 1977. The family members of the remaining 636 patients, 1568 in number, were subjected to the study.
During the third year, 289 were examined by the contacts examination, and the attendance rate was 18.4%. Among family members, 377 or 24.0% have not been examined at all during three years after the discovery of index cases. The attendance rate of contacts examination showed marked dif ference according to health centeres (Tables 1 and 2).
Two new cases were found during the third year, and among them 1 was found by the contacts examination and another one by symptomatic visit to a clinic. The detection rate of contacts exami nation was 0.3% and the overall detection rate to the total family members was 0.13%.
During past three years, altogether 45 cases were found. Comparing the detection rate by the bacteriological status of index case, it was higher among contacts of bacilli positive cases. The detec tion rate was higher during the first and second years, and it fell down in the third year (Table 3).
The reasonable way of carrying out family contacts examination will be established after making further follow-up for another one or two years.抄録全体を表示PDF形式でダウンロード (908K) -
伊藤 慶夫, 平沢 喜久雄, 平野 徹, 森川 聡, 中俣 正美, 清水 三郎1979 年 54 巻 8 号 p. 435-444
発行日: 1979/08/15
公開日: 2011/05/24
ジャーナル フリーThe aim of this study was to elucidate the sensitivity and specificity of the Kveim test in sarcoidosis. Between 1968 and 1978 we performed 119 tests. The results were analysed by dividing the term into two; A group between 1968 and 1974 and B group between 1975 and 1978.
The results obtained indicate the usefullness of this test, and are summarized as follows:
1. 38 cases were positive out of 103 histologically confirmed cases (36.9%). 15 cases were positive out of 56 cases (26.8%) in A group, while 23 cases positive out of 47 cases (38.9%) in B group. Positive rate in B group was always higher than that of A group even if subjects are subdivided into several categories by factors such as age, chest X-P, extrapulmonary lesions and PPD skin test.
2. Correlation between decreased PPD reactivity and Kveim positive test was observed.
3. Positive rate depended on the lot of test suspension. Test suspensions satisfying criteria defined by Silzbach were few in number, though such suspensions have been increasing.
4. Positive rate did not correlate with lymphocyte count as well as DNCB skin reaction.
5. Positive reactivity was not found in non-sarcoid subjects.抄録全体を表示PDF形式でダウンロード (3418K)
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