巻号一覧
52 巻, 5 号
選択された号の論文の6件中1～6を表示しています
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前川 暢夫, 池田 宣昭, 小田 芳郎, 裏辻 康秀, 稲掛 英男1977 年 52 巻 5 号 p. 211-218
発行日: 1977/05/15
公開日: 2011/05/24
ジャーナル フリーThe antituberculous activities of TUM and TUM-N were evaluated in comparison with other aminoglucoside antibiotics in vitro by using the silicone-coated slide culture method (SSC).
The results obtained are as follows: (1) The minimum inhibitory concentrations (MIC) of TUM and TUM-N are between 1.9 to 3.9μg/ml to H37Rv-S strain. However, the MIC of these drugs to the strains resistant to Viomycin (VM) and Capreomycin (CPM) are lowered to 62.5μg/ml and 31.3μg/ml, respectively. (2) The minimum bactericidal concentrations (MBC) of TUM and TUM-N are 3.9-7.8μg/ml to H37Rv-S strain, but remarkably lowered to the strains resistant to VM and CPM. These results indicate the existence of incomplete cross-resistance among these aminoglucoside antibiotics.抄録全体を表示PDF形式でダウンロード (882K) -
ウサギ赤血球とロゼットをつくらないリンパ球による反応の抑制露口 泉夫, 寺岡 修, 河面 孝, 白土 裕江1977 年 52 巻 5 号 p. 219-222
発行日: 1977/05/15
公開日: 2011/05/24
ジャーナル フリーIn guinea pigs, tuberculin-type delayed skin reaction was found to be suppressed by spleen cells which showed no rosetting with rabbit red blood cells (RRBC). Separation of spleen cells into RRBC-rosette forming cells (RFC) rich and RRBC-RFC depleted cells fractions was done by using Ficoll-Hypaque gravity sedimentation technique.
1) RRBC-RFC depleted spleen cells from guinea pigs immunized with complete Freund's adjuvant suppressed the skin reactions such as erythema and induration of their own animals when they were injected simultaneously at the same place of the injection of antigen TAP (Tuberculin Active Peptide).
2) In the experiment of local passive transfer of tuberculin-type delayed skin reaction to normal guinea pigs with lymph node cells from animals immunized with tubercle bacilli, RRBC-RFC depleted spleen cells from the same donor were found to suppress the reactions 24 hour later when injected with lymph node cells.
In both experiments 1) and 2), RRBC-RFC rich spleen cells showed rather enhancing activity. Treatment of the cells at 56μ for 30 min. abolished the suppressive activity of RRBC-RFC depleted spleen cells.
It remains to be elucidated whether suppressor cells observed above are B cells or belong to subset of T cells which do not from rosette with rabbit red blood cells.抄録全体を表示PDF形式でダウンロード (565K) -
山田 昇司, 小林 二郎, 笛木 隆三, 小林 節雄, 元山 誠, 富岡 真一, 山路 達雄1977 年 52 巻 5 号 p. 223-228
発行日: 1977/05/15
公開日: 2011/05/24
ジャーナル フリーThe incidence of tuberculous peritonitis has been decreasing recently, however, it is still an important disease in differential diagnosis.
Four cases of tuberculous peritonitis diagnosed by laparoscopy were reported.
Case 1. Fifty six year old man complained of abdominal distention, fever and anorexia was admitted to Tone Central Hospital. The patient had ascites. Laparoscopy and punch biopsy revealed findings of tuberculous peritonitis.
Case 2. Sixty year old woman. She was suffered from pleurisy at age of 30. A diagnosis of tuberculous peritonitis was established by laparoscopy and punch biopsy.
Case 3. Fourty eight year old housewife who had had an operation of spinal tuberculosis at age of 38 was admitted to the hospital because of fatigue, anorexia and fever.
The laparoscopy revealed changes of tuberculous peritonitis, and granulomas were also found in hepatic biopsy specimen.
Case 4. In 54 year old woman, a diagnosisof tuberculous peritonitis was established by laparoscopy.
All cases showed favourable course by the combination therapy with SM, PAS and INH.抄録全体を表示PDF形式でダウンロード (6021K) -
化療方式別にみた副作用の比較相沢 春海, 堺 一久, 岸田 賢一郎1977 年 52 巻 5 号 p. 229-234
発行日: 1977/05/15
公開日: 2011/05/24
ジャーナル フリーWe carried out investigations on side-effects manifested in 943 pulmonary TB patients admitted and treated with one of the following 5 regimens of tuberculosis chemotherapy in our hospital during the period from January to December, 1974.
39% of primary cases were treated with SM·EINH·ERFP regimen, 25% with SM·INH·EPAS and 18% with SM·INH·EEB regimens, respectively. Among re-treatment cases, 26% were on the four-drug-combination of KM·RFP·INH·EB, and 20% on RFP·EINH·EEB.
As for the incidence of side-effects, SM·INH·EPAS group showed a highest frequency of 54%, and among these cases one or more of the combined drugs had to be discontinued in 43% due to side-effects. In the SM·EINH·ERFP group side-effects occurred in 41%, and a part or all of the combined drugs had to be discontinued in 20%. In re-treatment cases, side-effects were observed in 49% of the KM·ERFP·EINH·EEB group, and drugs had to be discontinued in 26%. Among the RFP·EINH·EEB group, side-effects occurred in 42%, but drugs had to be discontinued in only 15% which was the lowest percentage of all groups.
83 to 98% of side-effects occurred during the initia1 2 months of therapy in each group.
In primary treatment cases, side-effects occurred among patients with light body weight, in all the treatment groups, while no correlation was observed between the body weight and the incidence of side-effects in re-treatment cases.抄録全体を表示PDF形式でダウンロード (806K) -
結核療法研究協議会1977 年 52 巻 5 号 p. 235-241
発行日: 1977/05/15
公開日: 2011/05/24
ジャーナル フリーThe Research Committee for Tuberculosis, Ryoken, conducted the cooperative study on the background factors of pulmonary tuberculosis patients staying long periods in 73 hospitals and sanatoria belonged to the committee in 1975.
The survey was performed on October 15, 1975.
In part 2, the reasons of long-stay in hospitals and sanatoria were analysed in 1, 936 cases staying for more than 5 years.
The results were summarized as follows:
1) Among 1, 936 patients, 664 (34.3%) had to stay due to failure of sputum negative conversion of tubercle bacilli. The commonest reason of treatment failure was that the patients were discovered in the days when anti-tuberculosis chemotherapy was not well advanced. The next common reasons were the late discovery of the disease or extremely far advanced tuberculosis at discovery.
2) The remaining 1, 272 patients were negative for tubercle bacilli. The reasons of long stay of negative cases were analysed, and the main reasons of long stay were the respiratory insufficiency (35.6%), the psychological worry for the disease (18.6%) and no acceptability of patients to their home (12.7%).
3) The majority of cases of long stay due to respiratory insufficiency showed the lower percent vital capacity and marked or moderate dyspnea. The proportion of patients of long stay due to respiratory insufficiency showed the close relation with the extent of pulmonary lesions, surgical treatment and respiratory complications.
4) As to the respiratory complications, emphysema was most frequently (15%) seen in all cases, and the empyema was most frequently seen in cases of long stay due to respiratory insufficiency.
Conclusively, to avoid the long-term admission of tuberculosis patients the earlier discovery of the disease and the initial intensive chemotherapy are essential.抄録全体を表示PDF形式でダウンロード (1018K) -
M. M. Abdel Kader, M. H. Abou El-Waffa, M. T. Abdel Aziz, A. M. Soffor ...1977 年 52 巻 5 号 p. 243-246
発行日: 1977/05/15
公開日: 2011/05/24
ジャーナル フリーChanges in carbohydrates, lipids, proteins and amino-acid metabolism have been described in tuberculous patients. It has been found that some indole derivatives are tuberculostatic both in vitro and in vivo.
Accordingly this work was directed to the study of the metabolism of some indole compounds in tuber culosis; namely serum total indoles, serotonin level in blood and urinary 5-hydroxy indole acetic acid (5-HIAA).抄録全体を表示PDF形式でダウンロード (355K)
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