We have reported the study on the factors in-fluencing the results of chemotherapy in April, 1960 at the Assembly of Japanese Society for Tuberculosis based on 1, 920 observed cases. Factors which may be related to the aggrava-tion rate after completion of chemotherapy were also discussed, because of the increase of the observed cases and of the elongation of obser-vation period.
We used the term “aggravation” instead of “relapse” or “recidiv”, because these terms “relapse” and “recidiv” mean the cases before cured whose new tuberculous lesion was discov-ered and the term “cured” has no clear defi-nition.
In this study “aggravation” means any radiol-ogical enlargement of the pulmonary lesion and, or, any newly recognized tuberculous shadows in the region of pulmonary area where no patho-logical shadows were observed by that time.
We observed 1, 774 cases of initial treatment and 675 cases of retreatment and observation periods after the end of chemotherapy are as follows: 1-year, 424 cases: 1-2 years, 443 cases: 2-3 years, 392 cases: 3-5 years, 438 cases: 5 years-, 77 cases.
Based on these cases, investigations were made on the various factors, namely, type of lesion at the end of treatment, age, size of the maximal lesion, kind of chemotherapy, its duration and radiological improvement at the end of chem-otherapy.
When we studied the influence of one factor, to exclude the influence of the other factors than the factor in quest, we compared the two groups which have the same rate of the other factors. Namely, the cases were first divided into the groups of initial treatment and retreatment and they were further divided by the type of lesion at the beginning of therapy and that at the termination of therapy. They were then further subdivided by the age, extent of lesion, maximal size of lesion, regimen of treatment, duration of treatment and the rate of improvement. The results were tabulated every 6 months. For comparison of one factor, the groups were so provided to contain other various factors distrib-uted in the same rate by taking the smallest number of the patients for each factor among the groups to be compared and randomely select-ing the same number of patients from the
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