The Joint Research Committee on Chemotherapy, Japan Antituberculosis Association in conjunction with the Cooperative Study Unit on Chemotherapy of Tuberculosis of National Sanatoria in Japan conducted a comparative study on the clinical effect of chemotherapy between sanatorium patients (S group) and chest clinic patients (A group). Sixteen chest clinics and 65 sanatoria participated in the research and 380 out-patients and 449 sanatorium patients were admitted in the trial during the period from April through July 1961.
Marked difference was found in the various background factors of cases between these two groups. (Table 1.) The percentage of males and younger patients were larger in S group than in A group, and the ratio of the far advanced cases was 3.2% in A group and 28.4% in S group, while the minimal cases was 77.1% and 25.6% respectively.
As it seems to be quite unreasonable to compare the two groups with different backgrounds as mentioned above, cases with similar background factors, as to the type and extent of lesion, kinds of chemotherapeutic regimens and age were selected from the two groups. Comparison of the therapeutic results among these two groups with the similar background factors revealed that the rate of regression of basic lesions was slightly higher in cases of S group than in A cases of group who continued working during treatment, but the difference was statistically significant only for cases with fibrocaseous type lesions at 3 and 12 months. (Figs. 1, 2, and 3)
S group was superior to A group as to the rate of cavity closure with statistical significance at 12 months (Fig. 5), while the rate of sputum conversion was almost the same for the two groups, (Fig. 4). Analysis based on the matched pair method confirmed the above mentioned conclusion. (Table 2)
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