巻号一覧
68 巻, 10 号
選択された号の論文の7件中1～7を表示しています
- |<
- <
- 1
- >
- >|
-
川上 健司, 倉島 篤行, 宍戸 春美, 永井 英明, 赤川 志のぶ, 川辺 芳子, 町田 和子, 毛利 昌史, 蛇沢 晶, 永武 毅, 松 ...1993 年 68 巻 10 号 p. 625-630
発行日: 1993/10/15
公開日: 2011/05/24
ジャーナル フリーWe had tuberculosis infection cases of gastrointestinal truct diagnosed histopathologicaly during January 1980 to december 1991 in TOKYO National Chest Hospital. Therewere 12 cases (male 8, female 4) from 24 y. o. to 88 y. o. (mean 50 y. o.). We got histopathological specimen by operation (6 cases), biopsy (4), and section (2). Pulmonaly tuberculosis wascomplicated in 8 cases, 7 cases had cavity formation and another case was milialytuberculosis. Distribution of tuberculous lesion was colon (7 cases), small intestines (5), cecum (2), rectum (1) and esophagus (1). First symptom was mainly abdominal symptom suchas abdominal pain and diarrhea. There were a perforative peritonitis and a intestinalobstruction during chemotherapy. Three died cases complicated low albuminamia. Wesuppose that serum albumin is one of the useful marker of patient's prognosis.抄録全体を表示PDF形式でダウンロード (3468K) -
治療開始時期の検討冨岡 治明, 佐藤 勝昌, 斎藤 肇, 日高 隆義1993 年 68 巻 10 号 p. 631-635
発行日: 1993/10/15
公開日: 2011/05/24
ジャーナル フリーTherapeutic efficacy of a newly synthesized benzoxazinorifamycin, KRM-1648, administered at the different periods of infection in Mycobacterium intracellulare-infectedmice was studied. Mice were infected intravenously with M. intracellulare (9.8-106 CFU/mouse) and then were given 0.4 mg of KRM-1648 emulsified in 2.5% gum arabic-0.2% Tween 80 by gavage, once daily six times per week, from day 1 to week 4, week 2 to week 6, week 4 to week 8, and week 8 to the end of experiment (week 12). Judgement of thetherapeutic efficacy of the drug against the infection was done on the basis of incidence anddegree of gross lung lesions, % organ weight (organ weight/body weight-100), and bacterialloads in the lungs and spleen. The lung lesions were not observed in the control and KRMtreatedmice at 4 weeks after infection (KRM treatment: day 1 to week 4). At 6 weeksafter infection (KRM treatment: week 2 to week 6), the lung lesions were observed in allcontrol mice, whereas 3 of the 5 mice given KRM-1648 did not show the lesions. At 8 weeksafter infection (KRM treatment: week 4 to week 8), the lung lesions were observed in allcontrol and KRM-1648-treated mice, but the degree of the lung lesions was much moreslight in mice given KRM-1648 than in control mice. The incidence and the degree of thelung lesions at 12 weeks after infection (KRM treatment: week 8 to week 12) was notdifferent in both groups. The % spleen weight between control mice and KRM-1648-treatedmice was found to be greatly different at 4 weeks after infection. The CFUs of organismsin the lungs and spleen were lower in mice treated with the agent than in control mice at 4 weeks after infection, but the rate of decrease became smaller with the lapse of time afterinfection. Thus, the chemotherapy started at 1 day to 2 weeks after infection with M. intracellulare was effective, but was not so in the advanced infection.抄録全体を表示PDF形式でダウンロード (539K) -
山口 靖明, 岸 幹二1993 年 68 巻 10 号 p. 637-643
発行日: 1993/10/15
公開日: 2011/05/24
ジャーナル フリーIn a routine PPD skin test among 1st grade pupils in 4 elementary schools, Fukushimaprefecture in April 1989, the number of pupils that showed strongly positive was unusuallyhigh. Moreover, 2 tuberculosis cases were detected among them. Since those childrengraduated the same kindergarten, and one of 6 kindergarten teachers had been complainingcough and hoarseness for about 3 to 5 months before being diagnosed as a smear positivepatient in the contact survey, she was suspected to be the source of infection. Meanwhile, she had been treated for common cold and chronic bronchitis in several clinics, therefore, the main cause of this epidemic was due to the doctor's delay in detecting the case.
With the discovery of 2 additional cases in the contact survey of the kindergarten, therewere 5 cases altogether including the index cases. Three of 4 children's cases had beenvaccinated with BCG. If the children who showed strong reaction to tuberculin andeventually treated prophylactically with isoniazid were asumed the infected, the rate ofdevelopment of disease among the infected was 13.6 to 27.3%. Usually, lymphnodeenlargement of the hilum is said not to be observed among vaccinated, though slightly, itwas evident among the cases in this epidemic.抄録全体を表示PDF形式でダウンロード (2842K) -
有田 健一, 大道 和宏, 江島 剛, 平田 知代, 藤原 恵1993 年 68 巻 10 号 p. 645-651
発行日: 1993/10/15
公開日: 2011/05/24
ジャーナル フリーIt is reported not only that the incidence of active tuberculosis has not decreased butalso that the cases of active tuberculosis who had been diagnosed at autopsy for the firsttime may have increased. The background factors and clinical courses of 13 cases of activetuberculosis whom we could not diagnose as tuberculosis until autopsy were investigated.According to the autopsy reports, the three fourths of the cases had active tuberculosislesions in several organs as miliary tuberculosis. All of the cases were treated in seriouscondition of liver cirrhosis, leukemia, and other malignant diseases.
Although fever of unknown origin was an important symptom, it was difficult to makea correct diagnosis because the fever was thought to be originated not from activetuberculosis but from the underlying diseases themselves. It was also difficult to diagnosefrom chest x-ray findings unless tuberculosis was suspected clinically.The education about tuberculosis should be held repeatedly. And we should try to thinkfrom different direction for the strange and unexpected clinical features of the patientswith liver cirrhosis, leukemia, and other malignant diseases.抄録全体を表示PDF形式でダウンロード (915K) -
寺嶋 毅, 梅田 啓, 坂巻 文雄, 金沢 実, 川城 丈夫1993 年 68 巻 10 号 p. 653-656
発行日: 1993/10/15
公開日: 2011/05/24
ジャーナル フリーA 54-year old man with pulmonary disease due to Mycobacterium xenopi is described. He had a history of pulmonary tuberculosis at 8 years of age. He was admitted to ourhospital in October 1992, complaining of productive cough and fever. A chest X-ray onoctober 20 showed an infiltrative shadow with a cavity, although chest X-ray picture onoctober 2 showed only inactive shadow, in the right upper lobe. Acid-fast organisms wereseen in his sputum specimens and M. xenopi was identified by culture. The isolates wereconfirmed to be M. xenopi by the DNA-DNA hybridization method. He was treated withisoniazid, rifampicin and streptomycin. The fever decreased within a week. After twomonths of therapy, sputum cultures became negative and chest X-ray findings improved. It was concluded that this is a case of rapidly progressed pulmonary disease caused by M. xenopi in the normal host. This patient's condition responded to antituberculosis drugs.抄録全体を表示PDF形式でダウンロード (3390K) -
森 亨1993 年 68 巻 10 号 p. 657-666
発行日: 1993/10/15
公開日: 2011/05/24
ジャーナル フリーThe main purpose of this paper is to demonstrate relevance of the medical technologyassessment (MTA) approach in the decision making process in the tuberculosis controlprogramme. Recently MTA has progressed remarkably under the pressure of limited medicalresources and necessity for rational utilization of those resources. This approach has alsobeen assisted by the development in related technologies, such as statistics and themanagerial sciences. The author demonstrates the feasibility of the MTA approach intuberculosis control programmes, with special emphasis on the applicability of themathematical model in risk-effectiveness analysis, citing several examples from his recentworks.A critical analysis of the screening chest radiophotography (Mass Miniature Radiophotography, MMR) is a good sample of risk-effectiveness analysis, where benefitfrom early detection of tuberculosis is quantified and compared with the possible risk dueto radiation exposure. A mathematical model is used to simulate the fate of tuberculosispatients with or without treatment. The benefit is computed in terms of lives saved, lifeyears extended, and treatment costs saved with or without the MMR programme. In Japan, it is concluded that MMR cannot be rationalized as a life-saving intervention in youngage-groups, nor being economically cost-effective for wider age ranges.
Based on the estimated trend of risk of infection of Japan now and in the near future, the infection status of a cohort born around 1990 can be calculated. Applying risk of clinicalbreakdown of tuberculosis to the above infection status and the assumed level of protectiveefficacy of BCG vaccination, assessment of the BCG vaccination programme can be made, under various hypothetical modes of vaccination, whether vaccinated to the newborn or toschool entrants, whether revaccinated or not, and when, etc. The analysis revealed that therevaccination has very limited effectiveness, which in turn emphasizes the importance of theprimary vaccination with optimum technical level.抄録全体を表示PDF形式でダウンロード (1634K) -
厚生省保健医療局結核・感染症対策室1993 年 68 巻 10 号 p. 673-675
発行日: 1993/10/15
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (347K)
- |<
- <
- 1
- >
- >|