巻号一覧
66 巻, 4 号
選択された号の論文の6件中1～6を表示しています
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木野 智慧光, 佐藤 瑞枝, 岩崎 龍郎, 青木 正和, 木原 和郎, 森 亨, 高瀬 昭, 木下 次子, 山口 智道, 金城 毅, 小渡 ...1991 年 66 巻 4 号 p. 291-297
発行日: 1991/04/15
公開日: 2011/05/24
ジャーナル フリーIn order to know the adequate duration of the chemotherapy with two drugs (INH+RFP) for pulmonary tuberculosis with non-cavitary minimal radiological findings (minimal case), 278 cases with minimal lesion which had completed 9 months'chemotherapy, were observed for more than six months up to 5 years (mean duration=54.4 months). Of them, 60 cases were bacteriologically confirmed by smear and/or culture examination. Many cases showed further improvement in radiological findings even after the end of the chemotherapy. Of 180 cases of initially infiltrative type (GAKKEN B type), 10 cases showed the enlargement of shadow radiologically, but were not regarded as relapsed cases, because they remained bacteriologically negative and the shadow improved in 1-2 months without additional chemotherapy. Only 3 cases (1.1%) were regarded as relapsed cases because of the positive bacteriological conversion and aggravation of the shadow. They were initially sputum negative. It can be concluded that for radiological minimal cases, nine months is enough for the duration of chemotherapy when the INH-RFP regimen is used.抄録全体を表示PDF形式でダウンロード (923K) -
近畿地区国療胸部疾患研究会 , 中江 一郎, 中谷 光一, 井上 修平, 高橋 憲太郎, 池田 宣昭, 松本 鉄也, 小澤 真二, 坂谷 光 ...1991 年 66 巻 4 号 p. 299-307
発行日: 1991/04/15
公開日: 2011/05/24
ジャーナル フリーOfloxacin, a synthetic antibacterial pyridone-carboxylic acid derivative, was used in the treatment of intractable pulmonary tuberculosis. In this study, the therapeutic effect of Ofloxacin on pulmonary tuberculosis and Ofloxacin resistance were analyzed. All patients had been hospitalized in eight national sanatoria in Kinki district, and were excreting tubercle bacilli resistant to various anti-tuberculosis drugs agents. Ofloxacin was given to 118 patients orally at a daily dose of 300mg to 600mg for more than 3 months. A few anti-tuberculosis drugs, which had failed in the negative conversion of bacilli previously, were used in combination. By Ofloxacin, 23 patients (19.5%) showed negative conversion of tubercle bacilli in sputum culture within 5 months, and they remained culturenegative for at least 6 months after conversion. Side-effects were observed in 2 patients. One complained of arthralgia and the other felt abdominal fullness. But both were not serious. From these results, it was concluded that Ofloxacin was effective for intractable pulmonary tuberculosis. The resistance of tubercle bacilli to Ofloxacin increased significantly after it was used.抄録全体を表示PDF形式でダウンロード (1133K) -
志知 泉, 佐藤 篤彦, 千田 金吾, 安田 和雅, 立田 良廣, 本多 淳郎, 和田 龍蔵, 山崎 晃1991 年 66 巻 4 号 p. 309-317
発行日: 1991/04/15
公開日: 2011/05/24
ジャーナル フリーA retrospective study on the evaluation of antituberculous drugs for patients with hepatic dysfunction was undertaken to clarify treatment regimens. The values of GOT, GPT and T. Bil were used as indicators of liver function, and the “deterioration” in the liver function was defined as a level greater than 1.5 times the initial value.
Of total 538 cases of active pulmonary tuberculosis, 103 cases (19.1%) had abnormalities in liver functions before chemotherapy, and 21 of 103 cases showed the deterioration in their liver functions during chemotherapy. There was little relationship between the initial status of liver functions and the incidence of their deteriorations after chemotherapy.
Nine of 21 cases did not exceed the 3 times of normal ranges of liver functions. These nine cases could tolerate the same regimens of chemotherapy, and showed satisfactory clinical responses to chemotherapy with two exceptions: one died of tuberculosis and the other cerebrovascular disease. On the other hand, of 12 cases with elevated values of hepatic function greater than 3 times the normal limits, 6 cases discontinued chemotherapy. One case, however, died of hepatic failure related to chronic active hepatitis. Eight of 12 cases showed the rapid improvement of liver dysfunctions.
These results suggest that antituberculous drugs are acceptable to patients with hepatic dysfunction as long as the elevations of GOT, GPT and T. Bil stay within 3 times of normal limits. Further chemotherapy could be continued under careful monitoring of liver functions even if the cases exhibit elevated levels of liver functions greater than 3 times the normal ranges.抄録全体を表示PDF形式でダウンロード (1164K) -
矢守 貞昭, 束村 道雄1991 年 66 巻 4 号 p. 319-321
発行日: 1991/04/15
公開日: 2011/05/24
ジャーナル フリーOne hundred strains of Mycobacterium tuberculosis isolated in 1988-89 from patients who were newly hospitalized in the National Chubu Hospital were studied on their biochemical and biological characteristics and compared with the strains isolated previously. Recently isolated strains showed frequently a much stronger arylsulfatase activity, grew at a higher rate at 42°C, and showed a little stronger niacin production.抄録全体を表示PDF形式でダウンロード (277K) -
新時代の結核対策日本結核病学会予防委員会1991 年 66 巻 4 号 p. 323-350
発行日: 1991/04/15
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (4114K) -
厚生省保健医療局結核・感染症対策室編1991 年 66 巻 4 号 p. 359-360
発行日: 1991/04/15
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (261K)
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