巻号一覧
70 巻, 2 号
選択された号の論文の8件中1～8を表示しています
- |<
- <
- 1
- >
- >|
-
檜垣 浩一, 宇野 道彦, 白石 恒明, 住田 信也, 大野 高義, 市川 洋一郎, 大泉 耕太郎1995 年 70 巻 2 号 p. 87-91
発行日: 1995/02/15
公開日: 2011/05/24
ジャーナル フリーAlthough the incidence of pulmonary tuberculosis had been rapidly decreased in Japan, it is pointed out that the rate of decrease in annual incidence became smaller in recentyears. This slowing down of the rate of decrease is considered to be resulted from anincrease in number of individuals who are more susceptible to tuberculous infection; suchas the elderly, young people who are not exposed to TB bacilli previously and therefore notimmunized, patients with malignant disease or with organ transplantation and HIVinfectedpersons.
Pulmonary tuberculosis still remained as a pulmonary infectious disease of highlyranked importance. Especially, miliary tuberculosis is life-threatening and occasionallyfatal unless early intensive antituberculosis chemotherapy was started on the basis of arapid and definite diagnosis.
We made a retrospective survey to clarify the characteristic clinical features of miliarytuberculosis. For this purpose, we compared the characteristics and clinical features of 10patients with miliary tuberculosis and those of 18 patients with severe pulmonarytuberculosis, not due to hematogenous dissemination.抄録全体を表示PDF形式でダウンロード (548K) -
是久 哲郎, 城戸 春分生1995 年 70 巻 2 号 p. 93-96
発行日: 1995/02/15
公開日: 2011/05/24
ジャーナル フリーChest mass examination for foreign students of Japanese-language schools in Fukuokacity was performed in 1991, and 1992. In 1991, 3 out of 237 students and in 1992, 9 out of657 students were registered as pulmonary tuberculosis patients. Their home countries were China, Taiwan, and Korea. The incidence rates were 1, 266 and 1, 270 per 100, 000 persons in 1991 and 1992, respectively, and were much higher than those of corresponding Japanesegroups in the same period.
Patients of severe types of pulmonary tuberculosis or smear positive cases were few.Though the treatments were interrupted in 4 out of 12 patients because of their return totheir home countries, in the others the success rate of the treatment was as good as in Japanese patients.
It is recommended that health examination including chest radiography should beperformed for foreign students of Japanese-language school as soon as possible after theirentrance to Japan.抄録全体を表示PDF形式でダウンロード (496K) -
冨岡 治明, 佐藤 勝昌, 斎藤 肇1995 年 70 巻 2 号 p. 97-101
発行日: 1995/02/15
公開日: 2011/05/24
ジャーナル フリーWe evaluated the in vitro antimicrobial activity of T-3761 and ofloxacin againstrepresentative pathogenic mycobacteria by the agar dilution method, using 7H11 agarmedium. T-3761 showed appreciable antimicrobial activity against Mycobacteriumtuberculosis (MIC90: 3.13μg/ml), M. kansasii (MIC90: 6.25μg/m/) and M. fortuitum (MIC90: 3.13μg/ml), whereas the agent was not active against M. marinum (MIC90: 25μ g/ml), M. scrofulaceum (MIC90: 50μg/ml), M. avium (MIC90: >100μg/ml), M. intracellulare (MIC90: >100μg/m/), M. chelonae subsp. abscessus (MIC90: >100 μg/ml) andM. chelonae subsp. chelonae (MIC90: 50μg/ml). The in vitro antimicrobial activity of T3761 against M. fortuitum was a little more potent than that of ofloxacin, whereas theactivity of T-3761 against the other mycobacteria was slightly inferior to that ofofloxacin. The antimycobacterial activity of T-3761 against M. tuberculosis H37Rv (MICin vitro: T-3761=3.13μg/ml, OFLX=0.78μg/ml) phagocytosed in murine peritonealmacrophages was less active than that of ofloxacin, when the macrophages were cultured inRPMI-1640 medium containing 1μg/ml or 10μg/m/ of these agents for up to 5 days. Theactivity of 10μg/ml of T-3761 was equivalent to that of 1μg/ml of ofloxacin.抄録全体を表示PDF形式でダウンロード (486K) -
新美 岳, 間瀬 裕司, 秋田 裕子, 馬嶋 邦通, 飯島 直人, 吉川 公章, 長谷川 由美, 伊奈 康孝1995 年 70 巻 2 号 p. 103-110
発行日: 1995/02/15
公開日: 2011/05/24
ジャーナル フリーWe report severe cases of pulmonary tuberculosis with respiratory failure who requiredmechanical ventilation. Of 99 patients with pulmonary tuberculosis admitted to Daido Hospital from November 1991 to November 1993, 6 patients had been mechanicallyventilated. Four of these 6 patients were vegrants and had long delay from onset of thesymptom to the admission. Chest X-rays of ventilated patients showed bilateral, extensiveshadows consistent with those of typical pulmonary tuberculosis, and a large number ofacid-fast bacilli were detected in their sputa. Though all ventilated patients except one HCV carrier had no underlying disease, they showed remarkable emaciation and malnutrition. They also showed weak PPD-skin reactions and reduced number of lymphocytes thatsuggested immunological disorders. Four cases have recovered, so we conclude thatmechanical ventilation is necessary and useful for the treatment of severe cases ofpulmonary tuberculosis.抄録全体を表示PDF形式でダウンロード (6734K) -
福岡 和也, 長 澄人, 濱田 薫, 米田 尚弘, 成田 亘啓1995 年 70 巻 2 号 p. 111-115
発行日: 1995/02/15
公開日: 2011/05/24
ジャーナル フリーA 58-year-old woman, not having any history of pulmonary tuberculosis, wasadmitted to our hospital to examine a tender lump in her right breast. A breast echogramdisclosed a well-defined hypoechoic mass lesion, indicating a pyogenic breast abscess.
The patient underwent incision, drainage and resection of the tumor under localanesthesia. Histological findings of the resected tumor revealed epitheloid cell granulomaswith caseous necrosis in mammary glands, suggesting tuberculosis of the breast. Afteroperation, treatment with isoniazid, rifampisin and ethambutol hydrochloride was begun.After one year, she had complete healing without any indication of recurrence.
During the last 10 years, 12 cases of tuberculosis of the breast have been reported. Theirages ranged from 28 to 84 years with an average of 42.8 years. Only one cases had a pasthistory of tuberculosis and in the other cases tuberculosis of the breast was considered to bea primary disease. Axillary lymph-nodes involvement and formation of pyogenic breastabscess occurred in each 7 cases. Acid-fast bacilli were demonstrated in 25% of the reportedcases. The histological findings of resected specimens and punch biopsy revealed epitheloidcell granulomas with caseous necrosis in 11 of 12 cases. Seven of 11 cases were treated withcombination of surgery and antituberculous chemotherapy.抄録全体を表示PDF形式でダウンロード (4335K) -
小西 裕之, 桑原 修, 宮崎 実, 西川 秀樹1995 年 70 巻 2 号 p. 117-120
発行日: 1995/02/15
公開日: 2011/05/24
ジャーナル フリーBoth of tuberculous mesenteric lymphadenitis and tuberculous peritonitis are nowrather rare in parallel with the decrease of the incidence of tuberculosis as a whole. Here, we report a case of tuberculous mesenteric lymphadenitis complicated with tuberculousperitonitis.
A 28-year-old man was admitted to our hospital with pulmonary tuberculosis.Antituberculous chemotherapy was started and his chest X-ray findings were improved.After 11 weeks of the treatment, high fever of 39.0°C developed suddenly and he complainedright lower abdominal pain. During laparotomy performed on suspicion of acuteappendicitis, swelling of mesenteric lymph-odes, numerous miliary tubercles on mesenteryand turbid ascites were noticed.
Diagnoses of tuberculous mesenteric lymphadenitis and tuberculous peritonitis wereconfirmed by bacteriological and histological examinations of lymph-nodes and tubercles.Ileocecal resection was performed and clinical course after the surgery was favourable.抄録全体を表示PDF形式でダウンロード (3574K) -
原 耕平1995 年 70 巻 2 号 p. 121-127
発行日: 1995/02/15
公開日: 2011/05/24
ジャーナル フリーThe application of molecular biology techniques for the rapid detection of mycobacteriain clinical specimens was evaluated. The DNA probe method was found to be accurate andrapid for identification of mycobacteria, but its low sensitivity needs improving. The nestedpolymerase chain reaction (PCR) targeting Pab gene was specific and sensitive enough forrapid detection of Mycobacterium tuberculosis in clinical specimens. The overall sensitivityand specificity of this method were excellent, 97% and 92%, respectively. Additionally, anovel method for the rapid detection of mycobacteria other than M. tuberculosis wasdeveloped using a combined method of PCR and DNA probe. The gene encoding 16Sribosomal RNA in mycobacteria was first amplified by PCR, and then PCR products wereidentified using an acridinium-ester labeled DNA probe. This method was as useful as thatof the PCR for M. tuberculosis described above. The DNA probe method was also appliedfor drug sensitivity testing, which needs three to four weeks by conventional methods. Thequantity of ribosomal RNA in mycobacteria cultured with or without the addition of drugswas compared. Three days after the start of culture, the strains sensitive for isoniazid orrifampicin showed remarkable decreases of ribosomal RNA, compared with the drug-freesamples, while the resistant strains showed no difference. Another method for determiningthe drug resistance of mycobacteria consists of detection of the gene which is related to theresistance. The deletion of catalase-peroxidase gene suggested a gene related to isoniazidresistance was observed in 15% of isoniazid-resistant strains. On the other hand, mutationin the RNA polymerase gene relating to rifampicin resistance was detected in 67% ofrifampicin-resistant strains. The application of molecular biology techniques may be anuseful future strategy for the diagnosis of mycobacteriosis.抄録全体を表示PDF形式でダウンロード (3136K) -
厚生省保健医療局エイズ結核感染症課編1995 年 70 巻 2 号 p. 131-136
発行日: 1995/02/15
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (666K)
- |<
- <
- 1
- >
- >|