This study was designed to determine the pharmacokinetics of (-)-Epigallocatechin gallate (EGCG) in yellowtail marine fish following oral gavage or intraperitoneal (IP) administration. After IP administration at a dose of 10 mg/kg body-weight, EGCG was detected in all plasma samples collected at 2 h post-dosing (2.22±1.46μg/
ml). It was markedly lower by 4 h and 8 h post-dosing, and not detected at later time points (< 0.066μg/
ml). After oral gavage, EGCG was only detected in plasma at 2 h post-treatment, and it was not detected in any muscle or liver samples. A one-compartment analysis revealed a high elimination rate constant (0.24) and a short half-life (2.89 h). These results suggest that EGCG may be poorly absorbed and/or quickly eliminated in yellowtail.
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