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Volume 59, Issue 7
Displaying 1-11 of 11 articles from this issue
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Hiroyasu KUMAMOTO, Yoshiharu MATSUBARA, Yoshitomi IIZUKA, Kozo OKAMOTO ...1985 Volume 59 Issue 7 Pages 677-682
Published: 1985
Released on J-STAGE: November 21, 2008
JOURNAL FREE ACCESSAn attempt was made to isolate hypotensive substances from hot water extracts of lemon peels. Eight flavonoid glycosides were isolated by repeated chromatography after extraction with butanol and treated with lead subacetate. Their structures were established by UV, MS, 1H-NMR and 13C-NMR spectroscopy, and sugar analysis to be : 6, 8-di-C-glucosyldiosmetin (8), 6-C-glucosyldiosmetin (9), 8-C-glucosyldiosmetin (10), isovitexine (11), apigenin 7-[6-O-α-rhamnosyl-β-glucose] (12), limocitrin 3-0-{[3-hydroxy-3-methylglutarate(1→2)]-β-glucose} (13), limocitrin 3-0-{[5-α-glucosyl-3-hydroxy-3-methylglutarate(1→2)]-β-glucose} (14) and limocitrol 3-O-{[5-α-glucosyl-3-hydroxy-3-methylglutarate(1→2)]-β-glucose} (15). Each component was intravenously injected into SHR-SP rats (1.0mg/100g body weight), and 8 was found to lower blood pressure. Among these compounds, 13, 14 and 15 were new flavonol glycosides.View full abstractDownload PDF (412K) -
Hiroyasu KUMAMOTO, Yoshiharu MATSUBARA, Yoshitomi IIZUKA, Kozo OKAMOTO ...1985 Volume 59 Issue 7 Pages 683-687
Published: 1985
Released on J-STAGE: November 21, 2008
JOURNAL FREE ACCESSAn attempt was made to isolate hypotensive substances from a hot water extract of yuzu. Eight flavonoid glycosides were isolated by repeated chromatography and gel filtration after extraction with butanol and treatment with lead subacetate. Their structures were established by UV, MS, 1H-NMR and 13C-NMR spectroscopy, and sugar analysis to be 3, 8-di-C-glucosylapigenin (1), hesperidin (2), naringin (3), narirutin (4), homoeriodictiol 7-[2-O-α-rhamnosyl-β-glucose] (5), hesperetin 7-{[α-rhamnosyl(1→2)]-[α-rhamnosyl (1→6)]-β-glucose} (6), naringenin 7-{[α-rhamnosyl (1→2)]-[α-rhamnosyl (1→6)]-β-glucose} (7) and (-)-cis-3, 5, 7-trihydroxy-3'-methoxyflavanone 7-[2-O-α-rhamnosyl-β-glucose] (8). Among these compounds, 7 and 8 were a new flavanone and dihydroflavonol glycoside, respectively. Each component was intravenously injected into SHR-SP rats (1.0mg/100g body weight), and a hypotensive effect was weakly present in only 7.View full abstractDownload PDF (350K) -
Mitsuto MATSUMOTO, Tatsuo HAMADA1985 Volume 59 Issue 7 Pages 689-693
Published: 1985
Released on J-STAGE: November 21, 2008
JOURNAL FREE ACCESSWistar rats were maintained under the following ultradian lighting schedule (light/dark, 6 hr:6 hr) : (1) group D, with lights on from 0300 to 0900 h and from 1500 to 2100 h; and (2) group L, reversal of the group D schedule, i.e., with lights on from 0900 to 1500h and from 2100 to 0300 h. Both groups were alternately given a high protein diet (HPD) from 0900 to 1200 h and a high carbohydrate diet (HCHD) from 2100 to 2400 h every 12 hr. That is, food was given during dark periods of the light-dark cycle in group D and during light periods in group L Other experimental conditions were rigidly standardized. After 4 weeks of feeding, the rats were decapitated at 0830, 1430, 2030 or 0230 h. In group D, ingestion of HPD decreased and HCHD increased cardiac glycogen. Similar changes were found with liver and skeletal muscle (gastrocnemius) glycogen and plasma glucose.
A reciprocal relationship was found between changes in cardiac glycogen in group D and group L. The 24 hr overall mean of cardiac glycogen was significantly higher (P<0.001) in group D than in group L. Changes in liver glycogen and plasma glucose in group L were similar to those in group D. As plasma free fatty acids (FFA) concentrations were decreased by ingestion of diets in both groups, a positive correlation was not present between cardiac glycogen and plasma FFA concentrations. Cardiac glycogen was affected by lighting conditions, in addition to feeding and diet composition. These results suggested that abnormal lighting conditions act as a stress on animals.View full abstractDownload PDF (458K) -
Takumi YOSHIZAWA, Tae SAKAMOTO, Kazumi OKAMOTO, Kohichiro OHTSUBO1985 Volume 59 Issue 7 Pages 695-701
Published: 1985
Released on J-STAGE: November 21, 2008
JOURNAL FREE ACCESSToxicological features of T-2 toxin (I) and in vivo T-2 metabolites such as 3'-hydroxy T-2 toxin (II), 3'-hydroxy HT-2 toxin (III), HT-2 toxin (IV), neosolaniol (V), 4-deacetylneosolaniol (VI), 15-deacetylneosolaniol (VII), and T-2 tetraol (VIII) were studied in ddy mice and in the protozoa Tetrahymena pyriformis GL.
The median lethal dose (mg/kg body weight) in intraperitoneally administered male mice (weighing 15±1g) and the median inhibitory dose (μg/ml medium) in exponentially dividing Tetrahymena cells were obtained. The respective values in mice and protozoa were: 4.79±0.43 and 0.0098±0.0016 for I; 4.63±0.63 and 0.75±0.20 for II; 22.84±2.04 and 0.78±0.04 for III; 6.50±0.51 and 0.31±0.11 for IV; 17.80±1.54 and 1.78±0.43 for V; 17.91±1.66 and 1.94±1.44 for VI; 12.59±1.13 and 3.02±0.63 for VII; and 22.31±2.22 and 1.97±0.60 for VIII.
II which is a major metabolite of I in vivo, showed acute toxicity comparable to that of the parent toxin. Such mice exhibited marked histopathological changes including epithelial necrosis in the intestinal mucosa and atrophic or hypoplastic changes in the thymus, spleen and bone marrow. On the other hand, major metabolite III showed a significantly weak lethal toxicity when administered intraperitoneally but it was highly toxic to Tetrahymena.View full abstractDownload PDF (1922K) -
Shin-ichi FUJITA, Kyoko NEZU1985 Volume 59 Issue 7 Pages 703-706
Published: 1985
Released on J-STAGE: November 21, 2008
JOURNAL FREE ACCESSThe essential oils of Mentha rotundifolia (Linn.) Huds. (Strain: piperitenone oxide, piperitone oxide, and 1, 2-epoxyneomenthyl acetate) were examined in detail. During the growing season (samples II_??_VII), (+)-piperitenone oxide content decreased from 85.1 to 1.3%, (-)-piperitone oxide concentration varied from 6.8 to 52.0% and then to 11.7%, with a maximum at the middle stage, whereas (+)-1, 2-epoxyneomenthyl acetate increased from 1.0 to 73.9%. The metabolic pathway creis discussed.View full abstractDownload PDF (239K) -
Keiichi TSUJI, Tadakazu TAKEO1985 Volume 59 Issue 7 Pages 707-709
Published: 1985
Released on J-STAGE: November 21, 2008
JOURNAL FREE ACCESSSeven sets of data for 30 green tea samples, i.e., sensorially evaluated grade, total soluble N and catechin contents, and three numerical data obtained from automatically recorded buffer capacity curves(βI, βII and _??_β), were respectively ranked, and the correlations between every pair of ranking data were examined by Spearman's method. High correlations were found between βI and jimi (a special term in green tea evaluation indicating a uniquely coordinated taste richness), βI and evaluated grade, βI and total N, and _??_β and catechin. The possibility was suggested for practical application of the buffer capacity data for green tea evaluation.View full abstractDownload PDF (205K) -
Shoichi TAKAO1985 Volume 59 Issue 7 Pages 711-715
Published: 1985
Released on J-STAGE: November 21, 2008
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1985 Volume 59 Issue 7 Pages 752
Published: 1985
Released on J-STAGE: November 21, 2008
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[in Japanese]1985 Volume 59 Issue 7 Pages 753-756
Published: 1985
Released on J-STAGE: November 21, 2008
JOURNAL FREE ACCESSDownload PDF (417K) -
[in Japanese]1985 Volume 59 Issue 7 Pages 756-758
Published: 1985
Released on J-STAGE: November 21, 2008
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1985 Volume 59 Issue 7 Pages 778
Published: 1985
Released on J-STAGE: November 21, 2008
JOURNAL FREE ACCESSDownload PDF (61K)
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