An antifungal isoflavone, wighteone [5, 7, 4'-trihydroxy-6-(3, 3-dimethylallyl) isoflavone,
1] was metabolized in cultures of
Aspergillus flavus and
Botrytis cinerea. The substrate (
1) was transformed by the former fungus into 2'', 3''-dihydro-3''-hydroxywighteone (wighteone hydrate,
4) and by the latter into dihydrofurano-isoflavone (
2) as major metabolites. A small quantity of dihydropyrano-isoflavone (
3),
2 and 2'', 3''-dihydrodihydroxywighteone (
5) were detected in the metabolic culture of
A. flavus as minor metabolites of
1. Both
3 and
5 were isolated as wighteone metabolites in
B. cinerea cultures.
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