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Volume 23, Issue 1
Displaying 1-14 of 14 articles from this issue
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99mTc-phosphateIsao IKEDA, Osamu INOUE, Junko UCHIDA, Yoshihiko SUGISAWA, Kunio KURAT ...1974 Volume 23 Issue 1 Pages 1-5
Published: January 15, 1974
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSAs previously reported, electrolysis method is one of the most convenient methods for labelling of several kinds of compounds with 99mTc. Now we have further expanded this method into other compounds such as bleomycin and chain phosphates, which are used as a tumor localizing agent and bone scanning agents respectively.
99mTc-chain phosphates, such as polyphosphate (n=12), tripolyphosphate and pyrophosphate were prepared by adding 99mTcO-4 soln. to Sn-chain phosphates solutions which were previously produced by electrolysis. The efficiency of labelling averaged more than 90% by allowing to stand this mixture for about 5 min. From the results of organ distribution study of 99mTc-chain phosphate with mice, we concluded that 99mTc-pyrophosphate was better bone scanning agent than the other two polymerized phosphates,
The results of further investigation showed that electrolysis method can be applied for labelling of several other compounds such as penicillamine and phytate.View full abstractDownload PDF (1969K) -
Atsushi ANDO, Kazuo NITTA, Kinichi HISADA, Masana OGATA1974 Volume 23 Issue 1 Pages 6-9
Published: January 15, 1974
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSIn order to investigate the relations between SMON and Quinoform, rapid synthesis of Quinoform-131I, -125I was developed. This method of the synthesis is as follows. 10 mCi of sodium iodide-131I, -125I (0.2 ml) was added to a solution of iodine monochloride (45.5 mg) in 3 ml of conc. hydrochloric acid under stirring and stirring was continued for ten minutes. 5-chloro-8-hydroxy-quinoline (50 mg) was added to this solution with stirring: a deep yellow crystalline solid precipitated out instantaneously. Stirring was continued for five minutes after the addition of 5-chloro-8-hydroxy-quinoline. The crystalline solid was then centrifugalized, washed with conc. hydrochloric acid. And this crystalline solid was decomposed by being added to water under stirring. The precipitate was centrifugalized, washed with water and 2% sodium thiosulfate solution to give a brownish white powder (Quinoform-131I, -125I), 4 mCi (radiochemical yield 40%) . Radiochemical purity of this compound was very pure by radiopaper chromatography and isotope dilution method.
This method of the synthesis is excellent for the purpose of producing Quinoform-131I, -125I, because the procedures were very simple and complete in a short time.View full abstractDownload PDF (500K) -
Yoshio YONAHARA, Yoshiko TAKAHARA, Hiroshi KIRIMURA, Yuichi FUKUIYA, M ...1974 Volume 23 Issue 1 Pages 10-15
Published: January 15, 1974
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSSince the last year we studied on quantitative determination of vitamin B12 in blood by competitive binding analysis using a sephadex intrinsic factor complex as a binder and obtained some findings as follows:
A standard curve obtained by diluting a standard vitamin B12dilution (1600 pg/ml) was slightly sigmoid in the range from 25 to 1600 pg/ml.
When the same sample was analysed in duplicate to check reproducibility, the variation coefficient was low, and the method was thought applicable to the clinical determination.
Changes of vitamin B12 in Blood by dilution of serum and recovery rates of vitamin B12 were studied. No fixed correlation between the observed values and the dilution rates was observed and mean recovery rate was 99.92%.
The normal range of vitamin B12in serum obtained with normal 50 subjects is 564.6 ±261.3 (210-1200) pg/ml.
After injecting 100 mg of tetrahydrofolate (FAH4) intramuscularly to normal subjects and patients with megaloblastic anemia, aplastic anemia, nephrosis and Banti's syndrome, changes of vitamin B12in blood were studied.
In patients with aplastic anemia, nephrosis and Banti's syndrome, significantly low values were obtained 2 to 4 hours after injection.
Though this method has to be studied further in some aspects, it is simple and many samples can be analyzed in relatively short time.
For this reason it is considered that the method would be widely applicable.View full abstractDownload PDF (624K) -
Masao OHTAKE, Toshimasa ONAYA, Takashi YAMADA1974 Volume 23 Issue 1 Pages 16-21
Published: January 15, 1974
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSBlood was obtained from normal subjects, pregnant women and hypertensioe patients at rest, after walk and during receiving diuretics, and plasma renin activity was measured by using radioimmunoassay kits supplied by two commercial sources. In order to get a reliable data, attempts were made to check the possible influences of dilution of plasma, error in making standard curve, variations of the data from kit to kit, error associated with the storage of the test materials and the importance of constant incubation.
In normal subjects, plasma renin activity (PRA) was low at rest and elevated after walk, but no diurenal variation was found. During pregnancy, PRA was apparently elevated but this high value subsided rapidly after delivery. The most of young patients with essential hypertension have normal or slightly high PRA, whereas older patients with essential hypertension have low normal or low PRA. Also, the patients with primary aldosteronism have low PRA. Administration of diuretics elevated PRA in patients with essential hypertension but failed to do so in primary aldosteronism. From the data accumulated, it is concluded that PRA is useful for differentiating sev-eral types of hypertension and for selecting the drugs for hypertension.View full abstractDownload PDF (605K) -
Masayoshi AKISADA, Tatsuya MIYAMAE, Toshiro YAMAZAKI1974 Volume 23 Issue 1 Pages 22-29
Published: January 15, 1974
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSIn the past two years we heve performed 100 cisterno grams covering 90 patients using 169Yb-DTPA as the radiopharmaceutical at the Department of Radiology, Mitsui Memorial Hospital.
The diagnoses of these cases were summarized in Table 1.
169Yb-DTPA was usually introduced into the lumbar intrathecal region and from the point the serial scintigams were followed from the spinal canal to the parasagittal areas ranging from 30 minutes, 1, 3, 6 and 24 hours after the administration. In some cases 48 and 72 hour scintigrams were supplemented.
The scintigrams were made by Toshiba Universal dual scanner and scinticamera. From the results we summarized our experiences with the interpretations of the cisternograms with special reference to normal anatomy which must be studied as the fundamentals for the reading of the abnormal cisterno grams under the pathologic conditions.
169Yb-DTPA cisterno gram could be scintigraphically divided into the following regions; C. magna, basal cisterns, C. fossae sylvii, C. quadrigemina, lateral ventricles and finally convexities and parasagittal areas.
The characteristics of the shapes of these cisterns and lateral ventricles were discussed. The appearance time of the radiopharmaceutical now available, i.e., 131I-HSA, 169Yb-DTPA in the adults and 99mTc-HSA in the children into each cistern were also discussed.View full abstractDownload PDF (7050K) -
Hikaru SETO, Kinichi HISADA1974 Volume 23 Issue 1 Pages 30-36
Published: January 15, 1974
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSHuman serum triiodothyronine (T3) was measured by “T-3⋅RIA KIT” and its usefulness was evaluated in 108 subjects with or without thyroid abnormalities. This kit is designed using 8-anilino-1-naphthalene sulfonic acid (ANS) to block T3-TBG binding for measurement of T3in unextracted serum. The antibody bound and free T3-are separated with dextran-coated charcoal.
Interassay reproducibility, assessed by measuring the identical sample 5 times was 3.5%. Interassay variation, evaluated by determining 7 paired specimens in three successive assays was 10.5%. The lower limit of sensitivity was always about 0.05 ng in 0.1 ml of hypothyroid serum and the range was 0.5 to 8.0 ng/ml. T3values observed are as follows: euthyroid 1.15±0.28 (SD) ng/ml, hypothyroid 0.33±0.01 ng/ml and hyperthyroid 5.15±1.81 ng/ml. The levels of T3parallel the thyroxine (T4) concentration in the sera of these subjects. The correlation coefficient was +0.84 despite the inclusion of fine subjects with hypertriiodothyroninemia.
A few puzzling conditions elucidated by the application of the T3assay are as follows:
(1) Hypertriiodothyroninemia-Five patients (4.6%) without therapy and ten patients after treatment with 131I for Graves' disease were hyperthyroid with raised T3and normal levels of total T4 and free T4. Another four patients developed overt hyperthyroidism, followed with increased T4.
(2) Euthyroidism with low T4-Three patients, one after treatment with 131I and the others without therapy were considered eumetabolic with normal level of T3, decreased T4 and increased TSH.
(3) Euthyroidism with low T3-Three patients, one after treatment with 131I and the others without therapy were considered eumetabolic witli normal levels of T4 and TSH, and decreased T3.
All conditions were found in patients after treatment with 131I for Graves' disease. Condition (2) is probably attributed that TSH hypersecretion may result in T3 release about as twice as that of T4. But in condition (3), TSH concentration was within normal range. We consider these two conditions as preclinical hypothyroidism.View full abstractDownload PDF (787K) -
Kinichi HISADA, Atsushi ANDO, Yutaka SUZUKI, Tatsunosuke HIRAKI, Itsuk ...1974 Volume 23 Issue 1 Pages 37-42
Published: January 15, 1974
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSThe tumor affinity of 57Co-bleomycin, 99mTc-bleomycin and 111In-bleomycin was examined by using Yoshida sarcoma-bearing rats, and inflammation affinity of these compounds was also tested by rats with inflammation induced by croton oil injection. In our experiments, 57Co-bleomycin had excellent biological characteristics as the tumor scanning agent, but 99mTc-bleomycin and 111In-bleomycin showed poor results compared to 57Co-bleomycin as the tumor scanning agent. All compounds were rapidly excreted in the urine. But retention values of 99mTc-bleomycin and 111In-bleomycin were similar to each of those of 99mTcO-4 and 111In-citrate than those of 57Co-bleomycin. And all compounds had relatively strong affinity to the inflammation tissue.
Half a millicurie of 57Co-bleomycin was injected intravenously to twenty-three patients with a variety of known malignancies and scintiphotos were obtained at six and twenty-four hours after injection. Two to three millicurie of 99mTc-bleomycin were injected intravenously to six patients in these twenty-three patients and scintiphoto were obtained at thirty and sixty minutes after injection. In case of 57Co-bleomycin, tumor were positively delineated in fifteen of twenty-three cases, but tumor were not positively delineated in patients administered 99mTc-bleomycin.View full abstractDownload PDF (2624K) -
Ikuro ANZAI, Masanori KANNO, Hirohiko TOBARI, Tomomitsu HIGASHI1974 Volume 23 Issue 1 Pages 43-47
Published: January 15, 1974
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSYtterbium-169 citrate has recently been put into medical use for external imaging of tumor tissues. The skeletal absorbed dose received by the patient was estimated in accordance with the MIRD Committee method. 500 micro-curie intravenous injection proved to result in 13 rads in skeleton, with the most important contribution of the internal conversion electrons emitted in the electron capture decaying process of the nuclide. The contribution of the penetrating radiations originating in other organs was found to be negligibly small. The average total body dose was approximately 2 rads.View full abstractDownload PDF (2311K) -
—for decreasing radiation dose—Keisuke KANAO, Takashi HARA, Yoshihiko MATSUYUKI1974 Volume 23 Issue 1 Pages 48-51
Published: January 15, 1974
Released on J-STAGE: July 21, 2010
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Atsushi ANDO, Kinichi HISADA, Tatsunosuke HIRAKI, Itsuko ANDO, Sigeru ...1974 Volume 23 Issue 1 Pages 52-54
Published: January 15, 1974
Released on J-STAGE: July 21, 2010
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Tatsuya MOTOKI, Yoshihisa KATO, Kazuo KAMII, Tohru MIGITA, Haruo KAMED ...1974 Volume 23 Issue 1 Pages 55-56
Published: January 15, 1974
Released on J-STAGE: July 21, 2010
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Takehiko TSUCHIYA1974 Volume 23 Issue 1 Pages 57-70
Published: January 15, 1974
Released on J-STAGE: July 21, 2010
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Chemical ExperimentsNaotake MORIKAWA1974 Volume 23 Issue 1 Pages 71-79
Published: January 15, 1974
Released on J-STAGE: July 21, 2010
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1974 Volume 23 Issue 1 Pages A1403-A956
Published: January 15, 1974
Released on J-STAGE: July 21, 2010
JOURNAL FREE ACCESSDownload PDF (3595K)
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