A chelating agent-loaded resin consisting of an anion exchange resin (Dowex 1 X-4) and bathocuproine disulfonic acid (BCS-resin) was prepared. The adsorption behavior of some chalcophile elements as a function of pH by the column method was studied, and mercury was shown to be adsorbed selectively to the BCS-resin at the pH region of 0.5-1.0, and the BCS-resin was found to be a specific collector for trace mercury in natural water samples before neutron activation analysis. The molar ratio of BCS to mercury (II) in the resin was confirmed to be 1: 1 and the resulting chelate was stable at least within a month. The method was applied to the determination of mercury in the Watarase river water sample. The sample solution was adjusted to pH 1.0 with HNO3, filtered and flown through the column (BCS-resin : 4×10-4 mol⋅g-1⋅resin, 7 mmφb×35 mmH) and the resin was then washed and dried in a desiccator. The monitor containing 10, μg of mercury was also prepared according to the above scheme. The samples and the monitor were irradiated together in the pneumatic tube of JRR-3 for 60 min (neutron flux: 2×1013 n⋅cm-2⋅s-1) . After cooling for 15 days, γ-activity of203Hg was measured. The result was 21±3 ppt for mercury, indicating that the method was well applicable to the determination of trace mercury in river water samples.
Although adrenal scintigraphy with131I-6β-iodomethyl-19-norcholesterol (NCL-6-131I) was used for the first noninvasive imaging of the adrenal glands, it has the disadvantages. These are; (i) relatively high radiation dose to patients, (ii) the long time required for completion of the scan. To solve these problems, 123I-labeled 6β-iodomethyl-19-norcholesterol (NCL-6-123I) was synthesized and was used for adrenal scintigraphy in 6 cases. Successful images were obtained with 185 MBq (5 mCi) -260 MBq (7 mCi) of NCL-6-123I, and optimal time required for the satisfactory scan was 2-3 days after the administration. The estimate radiation dose was redused by using 185 MBq (5 mCi) of NCL-6-123I instead of 18.5 MBq (0.5 mCi) of NCL-6-131I. From the result of this clinical study, NCL-6-123I was prefered for the adrenal scintigraphy.
The whole body scanning showed the distribution pattern of infused drug in continuous intra-arterially infused chemotherapy by using a gamma camera and infused RI (99mTc-MAA) from catheter. I measured the whole body scanning counts without shield (A) and with lead shield (B) on ROI and natural back ground counts (BG) . Then I calculated the distribution ratio on ROI as following. [ (A-B) / (A-BG) ] ×100 (%) . It was easy to find a certain relation between the catheter-top-position and the distribution ratio. As a result of investigating data, there were about 4 catheter-top-positions in aorta. Case by case, we putted the catheter-top in better position and prevented technical side effects and measured roughly total dose on ROI.