RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
Volume 19 , Issue 5
Showing 1-9 articles out of 9 articles from the selected issue
  • Mituhisa TAMURA, Tadato YAMAMOTO
    1970 Volume 19 Issue 5 Pages 223-228
    Published: May 15, 1970
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    As a novel application of 14 Me V neutron generator, the possibilities of hydrogen determination in hydrocarbons with recoil protons are discussed.
    High energy-recoil protons are produced from the collisions of the fast neutrons against the hydrogen nuclei. A mixture of hydrocarbon and boric oxide (B2O3) powder which has a large activation cross section for the protons was irradiated with the fast neutrons, and the activity of the powder was counted after removing the hydrocarbon from the powder. Half life of the boric oxide was about 20 minutes. This fact suggests that the reaction would mainly be caused by 115B (p, n) 116C
    Specific activity (A) of the boric oxide is shown as follows.
    A=k ρ WH
    where k is constant, ρ is hydrocarbon density, and WH is weight fraction of hydrogen in hydrocarbon. It would be possible to obtain hydrogen content by the measurement of A, because a simple estimation of ρ with hydrometer can be done.
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  • Haruo CHISAKA, Akiko SHINOMIYA, Yoshiharu SHINOZAKI
    1970 Volume 19 Issue 5 Pages 229-234
    Published: May 15, 1970
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    The effects of electron beam irradiation on p or n channel enhancement type MOS transistors, both prepared by the dry oxidation method have been investigated. The threshold voltage VT. shifts to negative side with the increase of irradiation dose. The result can be explained by the positive charges accumulated at the SiO2-Si interface.
    At the doses beyond 1014 elecrons/cm2, however, the threshold voltage shifts to positive side with the increase of irradiation doses. The result can not be explained by the positive charges only. In order to explain the result satisfactorily, the idea of“electron-trapping centers”has been introduced.
    The effective length (distance from SiO2-Si interface) over which the positive charges collect was estimated at 410Å.
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  • Wataru KIYOKAWA, Hirotake KAKEHI, Noboru ARIMIZU, Yukio TATENO
    1970 Volume 19 Issue 5 Pages 235-238
    Published: May 15, 1970
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    Sixty-nine cases including the hyper-, eu- and hypothyroid patients were studied using the Res-O-Mat and the resin sponge uptake (RSU) T3-kits. The index resulted from Res-O-Mat was well correlated with that from RSU, both showing the equal usefulness for the in vitro test of thyroidal function. The kits of different lot numbers were examined using the frozen serum of 4 cases in order to check the reproducibility of the test. The results obtained by the same frozen serum were varied to some extent; the deviation of the index was 2.5 to 11.0% with the resin sponge uptake kits and 2.5 to 3.8% with Res-O-Mat. The experiment was performed to see the effects of the incubate time on the index and it was suggested that the optimum incubate time would be 60 to 90 minutes.
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  • Atsushi ANDO, Kin-ichi HISADA
    1970 Volume 19 Issue 5 Pages 239-246
    Published: May 15, 1970
    Released: July 21, 2010
    JOURNALS FREE ACCESS
    67Ga-citrate is used for the clinical scanning of the malignant tumor, but the mechanism of its affinity for the tumor is unknown. In order to investigate the mechanism of the accumulation of 67Ga in the tumor, experiments were carried out as follows.
    Five chemical forms of 67Ga-citrate (carrier-free) , 67Ga-citrate (containing carrier Gacitrate) , 67Ga-nitrate (carrier-free) , 67Ga-nitrate (containing carrier Ga-nitrate) and 67Ga-EDTA (carrier-free) were prepared. Their affinities for the malignant tumor were examined. These five preparations were injected intravenously to the rats which had subcutaneously transplanted Yoshida Sarcoma and these rats were sacrificed 3 hours, 24 hours and 48 hours after the injection. The radioactivities of the tumor, blood, muscle, liver, kidney and spleen were measured by a well-type scintillation counter. The retention values (% dose per g tissue weight) in the tumor, blood, muscle, liver, kidney and spleen were calculated.
    67Ga-citrate (carrier-free) and 67Ga-nitrate (carrier-free) have very close affinities to the malignant tumor and their retention values in the tumor were approximately constant during 48 hours. Their excretion into urine was slower than other three preparations. The affinities of 67Ga-citrate (containing carrier Ga-citrate) and 67Ga-nitrate (containing carrier Ga-nitrate) for the tumor were weak and the excretion into urine was faster than those of carrier free. 67Ga-EDTA was rapidly excreted into urine and its affinity for the tumor was weak. Besides, the experiment with rats which had intraperitoneally transplanted Yoshida Sarcoma showed that 67Ga-citrate (carrier-free) and 67Ga-nitrate (carrier-free) were taken up considerably by Yoshida Sarcoma ascites cells.
    From these experimental results, it may be deduced that a suitable chemical form of 67Ga has strong affinity for tumors. 67Ga-nitrate becomes gallium-ion in water, and it is known that 67Ga-citrate becomes gallium-ion when it was diluted with the adequate amount of water. Therefore the chemical form suitable for the selective uptake by tumor cells should be carrier free and able to become gallium-ions easily in the body.
    Chemical properties of gallium were also studied. The binding capacity of gallium-ion to protein is not strong, but its binding capacity to glass is very strong. It is likely that the gallium-ion is either physiologically necessary for cancerous cells, or, if not, it has specifically strong affinity for tumors for unknown reasons.
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  • Katsuaki FUKUDA, Kazuyuki SUGIYAMA, Atsushi MIZUIKE
    1970 Volume 19 Issue 5 Pages 247-249
    Published: May 15, 1970
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Yoshiaki MARUYAMA, Kazuhide KOMIYA, Teruo MANRI
    1970 Volume 19 Issue 5 Pages 250-252
    Published: May 15, 1970
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Kazuo TAKADA, Yoshiki WADACHI, Mitsuo MURAMATSU
    1970 Volume 19 Issue 5 Pages 253-255
    Published: May 15, 1970
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Yoshikazu YOSHIDA, Ichiro MIYANAGA
    1970 Volume 19 Issue 5 Pages 256-262
    Published: May 15, 1970
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • 1970 Volume 19 Issue 5 Pages A1051-A616
    Published: May 15, 1970
    Released: July 21, 2010
    JOURNALS FREE ACCESS
    Download PDF (3933K)
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