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Volume 25, Issue 1
Displaying 1-14 of 14 articles from this issue
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Nagao IKEDA, Yasuko TAKAHASHI1976Volume 25Issue 1 Pages 1-6
Published: January 15, 1976
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSIn the studies on the non-equilibrium isotopic exchange method for determination of iodine in organic iodine compounds, activation energies have been measured to find systems having an appropriate rate of exchange reaction. The activation energies are discussed by considering the effect of structure of organic iodine compounds, the concentrations of reactants and solvent, etc. In homogeneous systems, activation energy is found to become larger in the order of CH3I<C2H5I<n-C3H7I <n-C4H9I <n-C6H13I <iso-C4H9I <CH2I2. As to the effect of solvents, activation energy is smaller in 100% acetone than in 90% acetone solution. In heterogeneous systems, e.g. Org. I (aq.) -I2 (CCl4 or C2H4Cl2), activation energy increases in the order of 3, 5-diiodotyrosine<3-iodotyrosine<5-iodouracil. The catalytic effect of I2 is large and the iodine ratio between I2 and organic iodine is a predominant factor in determining the rate o f exchange reaction.View full abstractDownload PDF (680K) -
Distribution of Na99mTcO4, 99mTc-colloid and 99mTc-MAA in Mice Studied by Whole Body AutoradiographyHiroshi SHIBATA1976Volume 25Issue 1 Pages 7-12
Published: January 15, 1976
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSThis study was undertaken to clarify the distribution of Na99mTcO4, 99mTc-colloid and 99mTc-macroaggregated albumin (99mTc-MAA) in mice mainly by means of whole body autoradiography.
In this study the whole body autoradiography was performed by the method particularly divised for short half lived radioactive isotopes. The radioactivity of the organ samples was assayed at 15, 30, 60 and 120 minutes after intravenous injection.
Na99mTcO4 was accumulated at high concentrations in thyroid, salivary glands, stomach, esophagus, seminal vesicle; secondly in liver, blood, lungs; at low concentrations in bone marrows, kidneys, spleen and other organs. Na99mTcO4 was hardly accumulated in brain.
99mTc-colloid was accumulated at high concentrations in liver; secondly in spleen, bone marrows; at low concentrations in lungs, kidneys and other organs. 99mTc-colloid was already accumulated in liver about 65% of the administered dose at 15 minutes after injection.
99mTc-MAA was accumulated at high concentration in lungs, while at low concentrations in kidneys, liver and other organs. 99mTc-MAA was already accumulated in lungs about 70% of the administered dose at 15 minutes after injection.
99mTc-colloid and 99mTc-MAA were hardly accumulated in thyroid, salivary glands and stomach.View full abstractDownload PDF (2617K) -
Shoichi NAKAGAWA, Takashi SASAKI, Hidetaka NAKAYAMA, Takuji WATANABE, ...1976Volume 25Issue 1 Pages 13-18
Published: January 15, 1976
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSA method of C-peptide radioimmunoassay with the synthetized connecting peptide by Yanaihara was tested for the determination of serum C-peptide immunoreactivity (CPR) in normal persons and diabetics with or without insulin treatment.
The CPR value obtained with this method was not interfered by the presence of serum proteins and insulin of persons with or without insulin treatment judged by the dilution test and the recovery test.
The normal fasting CPR was 2.80±0.78ng/ml with the synthetized C-peptide as standard and the CPR value increased and reached to the maximum at 90 minutes after the ingestion of 50 g of glucose. The increase after the glucose loading reduced corresponding to the severity of diabetes and some juvenile-onset diabetes showed no response. Adult-type diabetics under insulin treatment, however, showed weak but significant CPR response.
The increment of CPR and IRI after glucose loading in normal and non-treated diabetics was well correlated (r=0.8262) .
Judged from the above mentioned results, CPR determination in insulin-treated diabetics was thought to be a useful method for the assessment of the insulin-secreting ability of beta-cells of the pancreas.View full abstractDownload PDF (669K) -
A Study with 14CH3HgCl and CH3203HgCl in MiceEiichi OGAWA, Hiroshi TSUZUKI, Yayoe YAMAZAKI1976Volume 25Issue 1 Pages 19-23
Published: January 15, 1976
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSMice were given a tracer dose of 14CH3HgCl or CH3203HgCl either intraperitoneally or orally, and at 3 days thereafter, the distributions of the isotopes were examined. Also various chelating agents were given once daily for 3 consecutive days to study their effects on the distributions. At 3 days after the intraperitoneal injection of the radioisotopes, 14C concentration was significantly lower than 203Hg concentrations in the liver and kidney, but no change was elicited in the brain and blood. At 3 days after the oral administration of the isotopes, there were no changes in 14C and 203Hg. After the administration of BAL, cerebral concentrations of 14C and 203Hg were significantly increased. The administration of 2, 3-dimercaptosuccinic acid, 2-mercaptopropionyl glycine or penicillamine significantly lowered visceral concentrations of 14C and 203Hg. Of these three agents, dimercaptosuccinic acid was found most effective, when compared in one same dose. And glutathione and EDTA were disclosed by the present experiment to be ineffective in the elimination of mercury.View full abstractDownload PDF (464K) -
Osamu INOUE, Isao IKEDA, Kunio KURATA1976Volume 25Issue 1 Pages 24-30
Published: January 15, 1976
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSEight kinds of mercapto compounds were labeled with 99mTc by electrolysis method and electrochemical method which applied the corrosive reaction of tin electrodes.
In all compounds, more than 80% of the labeling efficiency was obtained under the suitable conditions. In some cases, however, insoluble species of 99mTc-hydrolized complex was also observed resulted in poor labeling yields.
Organ distribution of each 99mTc-mercapto compounds was compared in the mouse by organ radioassay from 1 min to 3 hrs after intravenous injection. 99mTc-DMS and 99mTc-TM had high affinity into kidney whereas 99mTc-TG, 99mTc-MP, and 99mTc-TL into both liver and kidney. However, 99mTc-TDG was rapidly excreted into urine without any focal accumulations. Although the organ uptakes greatly depend on the preparation method, those results indicated that 99mTc-DMS prepared by electrolysis method and 99mTc-TM prepared by electrochemical method might be useful for renal scanning.View full abstractDownload PDF (2187K) -
Shigemitsu ITO, Yoshizo ASANO, Shigeyuki HIROSE, Kazuo TSUZUKI, Takehi ...1976Volume 25Issue 1 Pages 31-36
Published: January 15, 1976
Released on J-STAGE: September 07, 2010
JOURNAL FREE ACCESSThe obstructive pattern renogram is usually demonstrated in obstructive uropathy. But some cases without obstruction also show this pattern. We applied furosemide (Lasix®) to such cases to differentiate false positive from obstruction. Furosemide was injected 20-40 mg intravenously to the cases with obstructive pattern renogram at 15-25 minutes.
In false positive cases rapid response, a marked fall of renogram curve to expected level of normal pattern, was observed in a few minutes (normal response) . On the contrary, no or incomplete response according to the severity was observed in cases with obstructive lesions. These responses were never observed in normal or non functioning pattern renograms.
By the analysis of intrarenal regional activities using sequential renal scintiphotograms, the fall of renogram curve is seemed due to decrease of activities chiefly in renal pelvic area by rapid wash out of radioisotopes with furosemide.
A case of urolithiasis with no response at first, showed incomplete response 4 days after operation and normal respose 4 weeks later. This incomplete response is probably resulted from incomplete obstruction and decreased response to furosemide as well.View full abstractDownload PDF (2379K) -
Tsuyoshi IMAHASHI, Isao FUJIKI, Shigemasa ENOMOTO1976Volume 25Issue 1 Pages 37-38
Published: January 15, 1976
Released on J-STAGE: July 21, 2010
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Masakazu TANASE, Eiji SHIKATA1976Volume 25Issue 1 Pages 39-41
Published: January 15, 1976
Released on J-STAGE: July 21, 2010
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Yoshiyuki MIURA, Hiroshi YAMADA, Fumio SUZUKI1976Volume 25Issue 1 Pages 42-45
Published: January 15, 1976
Released on J-STAGE: July 21, 2010
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Toshiyuki NAKAJIMA, Tatsuya TSUCHIDA, Toshitaka MATSUI, Tetsuo YAMAMOT ...1976Volume 25Issue 1 Pages 46-48
Published: January 15, 1976
Released on J-STAGE: July 21, 2010
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Tatsuya TOMITA, Atsushi MISHIMA, Hiroshi SAITO, Katsundo SHIBAMIYA, Hi ...1976Volume 25Issue 1 Pages 49-50
Published: January 15, 1976
Released on J-STAGE: July 21, 2010
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Takeshi TOMINAGA1976Volume 25Issue 1 Pages 51-59
Published: January 15, 1976
Released on J-STAGE: July 21, 2010
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Kenji SAEGUSA, Hirotake KAKEHI1976Volume 25Issue 1 Pages 60-70
Published: January 15, 1976
Released on J-STAGE: July 21, 2010
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1976Volume 25Issue 1 Pages A1595-A1146
Published: January 15, 1976
Released on J-STAGE: July 21, 2010
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