RADIOISOTOPES

Production of Pure ¹²³I by the ¹²⁷I (p, 5n) ¹²³Xe→¹²³I Reaction

Kazutoshi SUZUKI

1986Volume 35Issue 5 Pages 235-241
Published: May 15, 1986
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.35.5_235

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The excitation functions were measured for the nuclear reactions of ¹²⁷I (p, xn) ^{123, 125, 127}Xe. The maximum cross sections in the corresponding excitation functions were found to be 370 mb (at 54 MeV), 900 mb (at 29 MeV) and 280 mb (at 12 MeV), respectively. From the yield curves, thick target yields of ¹²³Xe and ¹²⁵Xe were estimated to be 5.2 GBq (140 mCi) /μA h in sodium iodide, irradiated by 60 Me V protons. The relationship among irradiation time, waiting time to generate ¹²³I from ¹²³Xe and outlet beam energy were discussed for the effective production of highly pure ¹²³I The yield of ¹²³I was calculated to be 0.52 GBq (14 mCi) /μA h in sodium iodide at optimum waiting time. For the practical production, an aqueous solution of 60% sodium iodide (10 mm thick) was irradiated at 3.2-4.1μA for 5-6 hours by 60 Me V protons under a flow of 30 ml/min helium gas which swept away ¹²³Xe generated in the target solution. 5.6-7.0 GBq (150 -190 mCi) of ¹²³I was obtained at the yield of 0.27±0.03 GBq (7.2±0.9 mCi) /μA h with 0.22±0.07% of ¹²⁵I contamination. The yield of ¹²³1 increased 1.6 times, using a solution of NaI (25%) +I₂ (50%) +H₂O (25%) .

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Synthesis of Optically Active Cyphenothrin-¹⁴C

—¹⁴C-Labelling at the vinyl carbon—

Hiroshi KANAMARU, Akira YOSHITAKE, Iwao NAKATSUKA

1986Volume 35Issue 5 Pages 242-248
Published: May 15, 1986
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.35.5_242

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Optically active cyphenothrins, α-cyano-3 phenoxybenzyl (1R) -cis- and (1R) -trans-chrysan-themates, were labelled with ¹⁴C at the vinyl position for use in metabolic studies. The key intermediates, (1R) -cis- and (1R) -trans-chrysanthemic- (propenyl-2-¹⁴C) acids (9a and 9b), were synthesized stereospecifically by applying the Wittig reaction of ¹⁴C-labelled phosphorane (6) with optically active formyl esters (7a and 7b) .

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Development of Neutral and Bifunctional Radiopharmaceuticals Using ⁶²Cu-Dithiosemicarbazone (DTS) Chelate

—Basic studies on ⁶⁴Cu chelates—

Akira YOKOYAMA, Takeo HOSOTANI, Yasushi ARANO, Kazuko HORIUCHI

1986Volume 35Issue 5 Pages 249-255
Published: May 15, 1986
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.35.5_249

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Recent plausibility of generator produced ⁶²Cu, a positron emitter is attracting the interest of those working in the development of bifunctional radiopharmaceuticals (BR) . In our development of bifunctional radiopharmaceuticals containing a neutral dithiosemicarbazone (DTS) metal chelate, tertiary (p-DPA-DTS) and quaternary (p-TPA-DTS) amino DTS derivatives were synthesized. As for the basic understanding of their divalent metal (Cu²⁺, Ni²⁺, Zn²⁺) complex formation and stability, spectophotometrical studies were carried out, comparatively with KTS. Upon assessment of preferential behavior of Cu chelate, the radiolabeled ⁶⁴Cu-DTS derivative chelates were tested in mice, and potential use with ⁶²Cu in positron nuclear medicine is discussed.

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Performance of Gamma Camera Collimators Used for Single Photon Emission Computed Tomography Imaging with ¹²³I-Isopropyl lodoamphetamine

Kenji SAEGUSA, Kimiichi UNO, Noboru ARIMIZU, Shouzo IBA, Sadao UEMATSU

1986Volume 35Issue 5 Pages 256-262
Published: May 15, 1986
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.35.5_256

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¹²³I Produced by ¹²⁴Te (p, 2n) ¹²³I reaction is contaminated with ¹²⁴I (<5%) and ¹²⁶I (<0.3%) . High energy photons from these mixed radioiodine compromise seriously image quality due to scattered photons and to septal penetration in the collimator. Four collimators of LEAP (for low energy all purpose), LEHR (for low energy high resolution), MESI (for medium energy made by Siemens) and MENU (for medium energy made by nuclear technology) mounted on a rotating gamma camera (Siemens, ZLC-7500), were examined in order to select a suitable collimator for ¹²³I SPECT (singel photon emission computed tomography) imaging.
Sensitivities were measured with a plane source (5×5×0.5 cm) at the collimator face and distances from 2 to 30 cm in air. And, spatial resolutions in FWHM (full width at half maximum) and FWTM (full width at tenth maximum) were determined from line spread functions with planar and SPECT imaging.
From the comparison of collimator performances with ^99mTe and ¹²³I, both collimators for low energy were not useful for ¹²³I imaging. In other two collimators for medium energy, however, apparently the effect of septal penetration by the higher energy photons were also recognized, MENU with high geometrical resolution was more suitable for ¹²³I SPECT imaging compared with MESI. And, it is important to perform the SPECT imaging with radius as short as possible.

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Adsorption of Iron (III) in Metal Chloride Solutions on the XAD-7 Resin and Its Application to Neutron Activation Analysis

Kiyoko IMAI, Kazuo WATARI, Shigeru OHNO, Kazuhisa SASAJIMA, Masami IZA ...

1986Volume 35Issue 5 Pages 263-265
Published: May 15, 1986
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.35.5_263

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Adsorption of Fe (III) on XAD-7 from LiCl, NaCl, KCl, RbCl, CsCl, CaCl₂ and AlCl₃ solutions was studied.
Fe (III) was quantitatively adsorbed on XAD-7 in high chloride concentrations above 6 M.
As an application of such adsorption behavior of Fe (III), determination of trace iron usually present as an impurity in reagent grade metal chlorides was examined. After adsorbing Fe (III) from high chloride concentrations on XAD-7, neutron activation was carried out on the resin. Iron amounts of 0.3 ppm, 1.6 ppm and 1.3 ppm were obtained with LiCl, CaCl₂⋅2H₂Oand AlCl₃⋅6H₂O, respectively.

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Thallium-201 Radioactive Implant Induced X-Ray Emission Scanning of Stable Iodine Distribution in Thyroid

—Phantom experiment—

Ryohei AMANO, Atsushi ANDO, Tatsunosuke HIRAKI, Norihisa TONAMI, Kinic ...

1986Volume 35Issue 5 Pages 266-269
Published: May 15, 1986
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.35.5_266

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A new method has been developed for imaging the thyroid gland by the use of ²⁰¹Tl radioactive implant induced X-ray emission (RIXE) . The thyroid phantom was made from two cylindrical tubes embedded in plastic neck phantom. Each tube consisted of stable iodine and ²⁰¹Tl radioactive source in 10 ml water solution. Some photopeaks in the energy range from 20 to 200 keV were scanned along a horizontal axis by the collimated Ge detector with high energy resolution. The distribution on the horizontal axis was obtained for the generated I K_a-ray and some primary ²⁰¹Tl radiations. The ²⁰¹Tl RIXE scanning can provide information about the distribution of iodine with ²⁰¹Tl as well as ²⁰¹Tl distribution in the thyroid gland. The effectiveness of the ²⁰¹Tl RIXE technique as a thyroid scanning method is discussed.

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Fundamental and Clinical Evaluation of a HBsAg-IgM Complex Radioimmunoassay Kit

Isao KANAMORI, Satoshi NAKANO, Toshitake YABASHI, Hiroshi YOSHIDA, Chi ...

1986Volume 35Issue 5 Pages 270-273
Published: May 15, 1986
Released on J-STAGE: December 13, 2010

DOIhttps://doi.org/10.3769/radioisotopes.35.5_270

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Clinical Evaluation of IgE ‘Eiken’ Kit by Double Antibody Method

Saori CHIBA, Hiroshi IWASAKI, Yumiko MACHIDA, Satomi HAKARIYA

1986Volume 35Issue 5 Pages 274-277
Published: May 15, 1986
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.35.5_274

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Land Disposal of Radioactive Waste in Advanced Countries

Sadahiro SAKATA

1986Volume 35Issue 5 Pages 278-287
Published: May 15, 1986
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.35.5_278

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Chemical Analyses by means of Nuclear and Radiation Methods—Applications to biology, medicine, pharmaceutical sciences, agriculture, science and engineering—

8. Instrumental Neutron Activation Analysis

Tetsuo MAMURO

1986Volume 35Issue 5 Pages 288-294
Published: May 15, 1986
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.35.5_288

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Chemical Analyses by means of Nuclear and Radiation Methods—Applications to biology, medicine, pharmaceutical sciences, agriculture, science and engineering—

8. (1) Instrumental Neutron Activation Analysis of Environmental Samples

Tetsuo MAMURO

1986Volume 35Issue 5 Pages 295-301
Published: May 15, 1986
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.35.5_295

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[title in Japanese]

1986Volume 35Issue 5 Pages A33P-A54M
Published: May 15, 1986
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.35.5_A33P

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