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Volume 61, Issue 1
Displaying 1-5 of 5 articles from this issue
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Article
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Takahiro KATAOKA, Rikizo TOKUNAGA, Akihiro SAKODA, Atsushi KAWABE, Kat ...2012 Volume 61 Issue 1 Pages 1-8
Published: 2012
Released on J-STAGE: January 27, 2012
JOURNAL OPEN ACCESSRadon inhalation using our radon exposure device activated anti-oxidative function in some organs of mouse. To assess the possibility of its application to veterinary care, healthy dogs and cats with chronic renal failure were inhaled radon at a concentration of 5500Bq/m3 for 30 minutes every 2 days for 30 days. In result, radon inhalation within a relatively long time period significantly decreased the triglyceride level of dogs. On the other hand, some cats increased the volume of drinking water by radon inhalation and the creatinine level in blood of these cats was decreased to normal level. These findings suggest that radon inhalation may have curative properties against chronic renal failure.View full abstractDownload PDF (809K)
Note
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Shigeo FUKANO2012 Volume 61 Issue 1 Pages 9-19
Published: 2012
Released on J-STAGE: January 27, 2012
JOURNAL OPEN ACCESSThe Radioisotope Pocket Data Book 11th edition gives values of the effective dose rate constants for two photon energy ranges of over 10keV and over 30keV.
To see the differences of the effective dose transmissions between above mentioned two energy ranges, over 10keV and over 30keV, we calcurated those for 125I and 241Am with five shielding materials, water, concrete, aluminum, iron, lead. Our new calcurated values were compared with conventionally used values.View full abstractDownload PDF (1877K)
Serial Lectures
Current Perspectives of Radiation Therapy
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Tetsuo AKIMOTO2012 Volume 61 Issue 1 Pages 21-29
Published: 2012
Released on J-STAGE: January 27, 2012
JOURNAL OPEN ACCESSCombined chemotherapy and radiation therapy has been established as standard treatment approach for locally advanced head and neck cancer, esophageal cancer and so on through randomized clinical trials. However, radiation-related morbidity such as acute toxicity also increased as treatment intensity has increased. In underlining mechanism for enhancement of normal tissue reaction in chemo-radiation therapy, chemotherapy enhanced radiosensitivity of normal tissues in addition to cancer cells. Molecular target-based drugs combined with radiation therapy have been expected as promising approach that makes it possible to achieve cancer-specific enhancement of radiosensitivity, and clinical trials using combined modalities have been performed to evaluate the feasibility and efficacy of this approach. In order to obtain maximum radiotherapeutic gain, a detailed understanding of the mechanism underlying the interaction between radiation and Molecular target-based drugs is indispensable. Among molecular target-based drugs, inhibitors targeting EGFR and its signal transduction pathways have been vigorously investigated, and mechanisms regarding the radiosensitizing effect have been getting clear. In addition, the results of randomized clinical trials demonstrated that radiation therapy combined with cetuximab resulted in improvement of overall and disease-specific survival rate compared with radiation therapy in locally advanced head and neck cancer. In this review, clinical usefulness of chemo-radiation therapy and potential molecular targets for potentiation of radiation-induced cell killing are summarized.View full abstractDownload PDF (411K) -
Hiroshi ONISHI, Naoki SANO, Kengo KURIYAMA, Takafumi KOMIYAMA, Kan MAR ...2012 Volume 61 Issue 1 Pages 31-43
Published: 2012
Released on J-STAGE: January 27, 2012
JOURNAL OPEN ACCESSStereotactic irradiation is defined as “the administration of high dose concentrated to small target volume with three-dimensional non-coplanar beams during short period”. Stereotactic body radiotherapy(SBRT) has been realized according to the progress of radiotherapy system, the improvement of set-up accuracy using immobilization and image-guidance technique, and management for respiratory motion. While stereotactic radiosurgery for intracranial lesions has more than 40 years' history, SBRT has at most 15 years' because of its technological difficulties. However, the increasing results of SBRT for small primary or metastatic lung tumors and liver tumors indicated good efficacy and safety, and showed good prognosis of stage I non-small cell lung cancer after SBRT that may be comparable to it after surgery. Here, the outline of SBRT was shown and the reason why it can result in the prognosis.View full abstractDownload PDF (1883K) -
Kazuo HATANO2012 Volume 61 Issue 1 Pages 45-55
Published: 2012
Released on J-STAGE: January 27, 2012
JOURNAL OPEN ACCESSIntensity-modulated radiation therapy(IMRT) is the treatment method which enables us to deliver a high dose to the tumor and to deliver a lower dose to surrounding normal structures. Since 2000, IMRT has been started it's clinical use in Japan mainly for the tumors of central nervous system(CNS), head and neck tumors(HNSCC) and prostae cancer. And national health insurance provided this fee for all localized malignant tumors from Apr. 2010. Hypofractionated high-dose irradiation by IMRT for GBM showed excelent local control in compared with conventional technique. The efficay of IMRT in sparing parotid glands, therby diminishing the severity of radiation-induced permanent xerostomia in selected patients, has been amply demonstrated during the past decade. And IMRT improved tha functional and QOL outcomes for patients with HNSCC. IMRT also reduced late rectal complication of prostate cancer patients. So, the number of IMRT treatment will be increased near future.View full abstractDownload PDF (1261K)
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