RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
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Volume 37, Issue 1
Displaying 1-11 of 11 articles from this issue
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  • 14C-Labeling of Bromobutide, 2-Bromo-3, 3-dimethyl-N- (α, α-dimethylbenzyl) butyramide
    Hiroshi KANAMARU, Kazuhiko NISHIOKA, Hiroshi KOMORI, Kazuo KAWAHARA
    1988Volume 37Issue 1 Pages 1-6
    Published: January 15, 1988
    Released on J-STAGE: September 07, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.37.1
    JOURNAL FREE ACCESS
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    Bromobutide, a novel herbicide, was labeled with carbon-14 independently at the carbonyl group and the phenyl ring for use in metabolic studies. 14C-Carbonation of neopentylmagnesium chloride (3) gave 3, 3-dimethyl [1-14C] butyric acid (4a) quantitatively. Chlorination of 4a with thionyl chloride followed by α-bromination with bromine yielded 2-Bromo-3, 3-dimethyl [1-14C] -butyryl halide (5a), which was subsequently condensed with α, a-dimethylbenzylamine (6a) to afford [carbonyl-14C] bromobutide (1a) . The overall yield of 1a was 76% from barium [14C] -carbonate (2) . Similarly, condensation of α, α-dimethyl [phenyl-14C] benzylamine (6b), which was prepared from α-methyl [phenyl-U-14C] styrene (7) in three steps, with 2-bromo-3, 3-dimethylbutyryl halide (5b) gave [phenyl-14C] bromobutide (lb) in 67% yield after purification. The specific activities of 1a and 1b were 1.38 and 0.781 GBq/mmol (37.2 and 21.1 mCi/mmol), respectively.
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  • Evaluation of Postoperative Hepatobiliary Function by Deconvolution Analysis of Hepatobiliary Image Data by 99mTc-N-Pyridoxyl-5-methyltryptophan
    Juroku GON, Tsuyoshi NAKAGAWA, Hisato MAEDA, Kazuyoshi NAKAMURA, Hajim ...
    1988Volume 37Issue 1 Pages 7-14
    Published: January 15, 1988
    Released on J-STAGE: September 07, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.37.7
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    Dynamic hepatobiliary image data were analyzed by the mathematical deconvolution to derive the transfer function (TF) which represents the impulse response function of the liver following direct bolus injection of a tracer into the liver. Biliary low was evaluated by TF in patients with previous hepatobiliary surgery to detect abnormal flow causing problems such as cholangitis.
    Serial image data were collected for 60 min after intravenous injection of 37-75MBq (1-2mCi) of 99mTc-N pyridoxyl-5-methyltryptophan (99mTc-PMT) . TF was obtained by the matrix algorithm, using regional hepatogram as output and time-activity curve over the heart as input function. Minimum, mean and maximum transit time (Max. TT) were determined from TF. The functional image for each of the transit times was constructed by displaying the distribution of the values for matrix elements with a color scale.
    In this study, a critical Max. TT of 60 min was used to detect abnormal biliary flow. Of 30 cases, 9 positive cases were discriminated from 21 negative cases on the basis of the finding of presence or absence of areas with Max. TT of more than 60 min anywhere in the liver. Bowel activity overlapping the liver was excluded in the judgement. The validity of this method was evaluated in comparison with the clinical courses after surgery with (8 cases) or withot (22 cases) problems. The results were sensitivity of 88%, specificity of 91%, accuracy of 90% and positive predictive value of 78%.
    The merit of the deconvolution analysis is that it provides independent information on excretory function in the form of TF which itself represents a spectrum of transit times. Factors relating to the blood flow does not affect the shape of TF, i.e. transit times, while factors of blood flow and excretion are combined in conventional hepatogram. This method will contribute to the follow-up and evaluation of hepatobiliary surgery.
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  • A Direct Radioimmunoassay for Serum 11-Deoxycortisol
    Naotake OGAWA, Atsushi SUGII, Riko INOUE, Teruhisa UMEDA, Tatsuo SATO, ...
    1988Volume 37Issue 1 Pages 15-18
    Published: January 15, 1988
    Released on J-STAGE: September 07, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.37.15
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    A simple direct radioimmunoassay for 11-deoxycortisol in serum is described. A new type of bridge heterologous 125I labeled 11-deoxycortisol was prepared and was applied to the direct radioimmunoassay. Low and high levels of 11-deoxycortisol in serum were sensitively determined by the direct radioimmunoassay.
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  • On the Factors Influencing the Dispersion of Radioiodines
    Nobuhiko ITO, Toshio MUTO, Shigeru TAKATA, Akiharu KITAHARA, Yoshinori ...
    1988Volume 37Issue 1 Pages 19-26
    Published: January 15, 1988
    Released on J-STAGE: September 07, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.37.19
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    Radioactivities dispersed from 0.1N sodium hydroxide solutions of 123I, 125I, or 131I were measured, and the factors influencing dispersion of radioiodines were analyzed. The radioiodines dispersed were trapped by glass fiber filters, charcoal filters, and separable paint. The factors influencing the dispersion of radioiodines are discussed in terms of the dispersal rate, which defined as the ratio of total activity of three kinds of traps in a unit time to whole activity. In order to clarify the factors influencing the dispersal rate, we carried out the experiments; on the effect of reducing agent, that of radioactive concentration of radioiodine, that of mixing the 125I solution with 131I, and that of scavenging hydrated electrons and hydroxyl radicals. It could be concluded from experimental results that the principal factors influencing dispersion of radioiodines are the number of atoms of radioiodine per volume and the energy absorbed in solution from radioiodines. In regard to the absorbed energy, we thought that the dispersion of radioiodines is influenced mainly by hydrated electron, not markedly by hydroxyl radical.
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  • Dry-distillation of Experimental Animal Wastes Containing Radioisotopes
    Hideo MIYATAKE, Kazumi SAITO, Norio KURIHARA
    1988Volume 37Issue 1 Pages 27-30
    Published: January 15, 1988
    Released on J-STAGE: September 07, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.37.27
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    Mice were dry-distilled at 800°C for 10 min, after [32P] orthophosphate or L- [4, 5 -3H] leucine was intraperitoneally administered. Phosphorus-32 was quantitatively recovered in the residual solid, whereas 95% of 3H was found in the distillate (condensed water) . When 14C (L- [U-14C] malic acid or L- [U-14C] leucine) was administered to mice and they were dry-distilled, 14C-radioactivity was distributed into two fractions; residual solid and exhaust gas. In these cases, the recovery percentage of 14C in residual solid was not very high but increased as the treating temperature decreased. It reached about 40% of the administered 14C at 400°C for 120min. By the drydistillation of animals, their weight was reduced to about 10% in every animal tested (mice, rats and rabbits) . The volume was reduced to about 20% in cases of mice and rats, and about 30% in case of rabbits. It was concluded that the drydistillation can be useful as a pre-treatment for disposal of animal wastes containing radioisotopes.
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  • Preparation of Solidified Biological Specimen by γ-Ray-induced Polymerization
    Kiyoshi HAYAKAWA, Reiji HIRAKOW
    1988Volume 37Issue 1 Pages 31-34
    Published: January 15, 1988
    Released on J-STAGE: September 07, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.37.31
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    Solidification of soft organisms at room temperature was achieved by γ-ray-induced polymerization of a hydrophilic liquid monomer exchanged with the inner water. Typical recipes are given for an egg of 2.5 cm in diameter and for a bulb of a plant. This technique would be applicable to preparation of the large permanent sections of biological specimens.
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  • Evaluation of the System Performance and Clinical Images of the Single Photon Emission Computed Tomography for Head Using Ring Arranged Detector
    Kazutaka EJIRI, Hiroshi TOYAMA, Yukihiko KATO, Takae NARITA, Gen TAKES ...
    1988Volume 37Issue 1 Pages 35-38
    Published: January 15, 1988
    Released on J-STAGE: September 07, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.37.35
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    To evaluate the system performance, several preoperational fundamental tests of single photon emission computed tomography (SPECT) were carried out. Spatial resolutions (FWHM) measured with the point-spread functions of a 99mTc line source were 12.5 mm with a high resolution (HR) collimator and 17.2 mm with a high sensitivity (HS) collimator respectively. Slice thicknesses (FWHM) obtained from the profile curves of slice images were 17.5 mm (HR) and 29.0 mm (HS) at the center of rotation. System sensitivities were 5.4 kcps/slice (HR) and 27.8 kcps/slice (HS) . Uniformities calculated from the SPECT images of a pool phantom were 4.7% (HR) and 2.7% (HS) at the condition of 3000 kcounts to be acquired.
    SPECT images of the HEADTOME SET-031 were considered very useful to diagnose the cerebrovascular disease.
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  • The Measurement of Parathyroid Hormone in Sera of Hemodialysis Patients with Renal lnsufficiency by Employing the Various Kinds of Parathyroid Hormone Kits
    Kazutami TORIZUMI, Hirofumi AIBATA, Yoshiyuki TANIGUCHI, Shigeyuki KIJ ...
    1988Volume 37Issue 1 Pages 39-42
    Published: January 15, 1988
    Released on J-STAGE: September 07, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.37.39
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    This study focussed on elucidating difference of blood PTH levels, by employing the various kinds of PTH kits. We carried out the measurements of PTH levels in sera of the hemodialysis patients with renal insufficiency presumably inac-tivated PTH degradative regulation in kidney. Our results showed the remarkable significant relationships among blood PTH levels of carboxyl and mid-region PTH and intact PTH in hemodialysis patients and was deduced that the differenee of PTH levels by using various kinds of PTH kits was responsible of PTH cleavage effect in the kidney.
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  • Heavy-ion Beam Analysis Applied to Surface Characterization for Material Study
    Michi ARATANI
    1988Volume 37Issue 1 Pages 43-52
    Published: January 15, 1988
    Released on J-STAGE: July 21, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.37.43
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  • Introduction to the Experiments of Genetic Engineering. IV. cDNA library
    (1) : Principles and applications
    Yutaka KAWARABAYASI, Tokuo YAMAMOTO
    1988Volume 37Issue 1 Pages 53-61
    Published: January 15, 1988
    Released on J-STAGE: July 21, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.37.53
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  • [title in Japanese]
    1988Volume 37Issue 1 Pages A1P-A10M
    Published: January 15, 1988
    Released on J-STAGE: July 21, 2010
    DOIhttps://doi.org/10.3769/radioisotopes.37.A1P
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