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—Model of Ammonia Metabolism and Functional Image Based on Animal Experiment—
Nobuo FUKUDA, Toru MATSUMOTO, Yoichiro UMEGAKI, Toru UCHIKAWA, Takeshi ...
1977 Volume 26 Issue 4 Pages
209-215
Published: April 15, 1977
Released on J-STAGE: September 07, 2010
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Ammonia has been known to be an inducing agent of hepatic coma associated with liver cirrhosis.
In order to establish a non-invasive method of investigating the portal circulation and the metabolism of ammonia at liver the following studies were performed, by using cyclotron produced 13N-
labeled ammonia and delayed line-camera interphased with on-line computer system.
1)
Animal experiment. Dynamic scintigraphy of thoraco-abdominal region of a rabbit after intrasigmoidal as well as intravenous administration of 18N-
ammonia were performed.
2)
Theoretical consideration on the functional image of liver: According to the results of the animal experiment, a model of ammonia metabolism having the minimal complexity necessary to represent data in the case of intrasigmoidal administration was proposed. Starting from the solution to the differential equation describing the model, relevant parameters characterizing the dynamic curve of liver were deduced.
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—Clinical Trial on the Functional Imaging—
Nobuo FUKUDA, Toru MATSUMOTO, Yoichiro UMEGAKI, Toru UCHIKAWA, Takeshi ...
1977 Volume 26 Issue 4 Pages
216-220
Published: April 15, 1977
Released on J-STAGE: July 21, 2010
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1)
Clinical application: Dynamic scintigraphy of liver and heart of a patient baying liver cirrhosis after intrasigmoidal administration of 13N-
ammonia (pH 8.1) were performed.Simultaneously, continuous measurments of radioactivity at the left side abdomen and the left temporal region were done by using a scintillation detectors for renography. Successive measurement of radioactivity of blood was also carried out.
2)
Construction of functional images of liver and heart: By using digital radioisotope image of liver and heart of the patient after intrasigmoidal administration of 13N-
ammonia, the maps with respect to parameters described in the previous paper were constructed.
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—Functional imaging based on Height/Area method—
Hisato MAEDA, Tsuyoshi NAKAGAWA, Nobuo YAMAGUCHI, Mitsuo TAGUCHI, Gisu ...
1977 Volume 26 Issue 4 Pages
221-227
Published: April 15, 1977
Released on J-STAGE: September 07, 2010
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The purpose of this presentation is to investigate following computer processing techniques in brain functional imaging of regional cerebral blood flow (rCBF10) based on Height/Area method using 133Xe.
That is,
1. Time interval of sequential map2. Map smoothing for sequential map3. Matrix size of sequential mapThe joint camera-computer system used in this study consists of the GCA-202 scinticamera and the DAP-5000 N computer system. Following intra-arterial injection of 3-5 mCi of 133 Xe,
5 second frames of data in 64×64 matrix form were acquired for a period of 14.5 minutes utilizing the computer system.
Automatic computation of rCBF10 and its relative standard deviation (RSD), was done for the washout curve in each element of the matrix.
In view of the effect on the values for rCBF10 the statistical error and the spatial resolution, the optimum conditions for rCBF10 functional imaging were concluded as follows,
functional imaging were concluded as follows,
1. Time interval 5 seconds2. Map smoothing method f=10.2 or 15.13. Matrix size 64×64 matrix formThus obtained functional image showed higher resolution and lower statistical error (mean RSD=5-8%) . All procedures required about 3 minutes with the on-line computer system.
It is considered that rCBF10 functional imaging is of special value for the assessment of regional cerebral blood flow and that it will be useful for daily clinical studies.
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Toshiyuki KIDA, Akira SUZUKI, Katsuko KOBAYASHI
1977 Volume 26 Issue 4 Pages
228-233
Published: April 15, 1977
Released on J-STAGE: September 07, 2010
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A study has been made of a simple and practical method to add the information of anatomical localization upon the emission scintiphoto of the generally used Polaroid film.
Our experients were as follows: first, the polaroid film of transmission scintiphoto, according to the Anger method, was made, and then, that of emission scintiphoto was made. Next, by double-exposing these two photos to the same polaroid film with the Mamiya-made duplicator, these photos were made into a composite photo. In that case, in order to distinguish the images of these scintiphotos on this composite photo, a colour Polaroid film was used in the double exposure, and here, when each of the two scintiphotos was given its own colour-filter, it was found that the images could be sharply sorted by colour.
This method does not require any highly expensive apparatuses and according to this method a disc source and a Polaroid duplicator are enough for the exact anatomical localization of scintiphoto-images by the Polaroid film.
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—The Stoichiometry and Characteristics of the Binding Equilibrium—
Goro KOMINAMI, Akira YOKOYAMA, Seiko KIKUMOTO, Hisashi TANAKA
1977 Volume 26 Issue 4 Pages
234-237
Published: April 15, 1977
Released on J-STAGE: December 13, 2010
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The stoichiometry and the characteristics of the TcO
4- binding equilibrium to human serum albumin were investigated by the use of 99TcO
4-.
Based on the Scatchard plots, the number of binding sites and the association constants were obtained at pH 7.38, 6.04, 5.10, 4.18, 2.80 and 0.65, respectively. From the parameters at pH 7.38, it was estimated that 64% of TcO
4- added was bound to human serum albumin under physiological condition. Variance in the values at pH 7.38, 6.04 and 5.10 shows that these bindings are stabilized by electrostatic forces. Below pH 4.18, the number of binding sites increased and the association constants diminished. These phenomena may be attributed to the conformation change of human serum albumin.
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—Unstable Metabolites in the Rats—
Juko SUGIHARA, Naomasa TAGA
1977 Volume 26 Issue 4 Pages
238-244
Published: April 15, 1977
Released on J-STAGE: September 07, 2010
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The colored substances excreted in bile or urine have been investigated after administration of a high dose of SA-504 to rats.
A reddish-violet colored substance and a bluish-violet colored substance were dominant. Their chemical structures were not assigned because of their small quantity and instability. It was recognized that the colored substances were metabolites of SA-504 from the studies with 3H
and 14C
labelled SA-504 and the derivatives of SA-504.
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Masatoshi FUJISHIRO, Tatsuo TABATA, Junichiro FURUTA, Eiichi HIRAOKA, ...
1977 Volume 26 Issue 4 Pages
245-247
Published: April 15, 1977
Released on J-STAGE: July 21, 2010
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Shigeichi MATSUMURA, Hideki OYAMA, Atsuko TENKU, Seikoh NISHIDA, Masah ...
1977 Volume 26 Issue 4 Pages
248-251
Published: April 15, 1977
Released on J-STAGE: July 21, 2010
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Haruo CHISAKA, Takashi SUZUKI, Yasuhiro HORIGUCHI, Yukio INOKOSHI, Yas ...
1977 Volume 26 Issue 4 Pages
252-254
Published: April 15, 1977
Released on J-STAGE: July 21, 2010
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Hiromi SAKAMOTO, Toshihide YAMAMOTO
1977 Volume 26 Issue 4 Pages
255-258
Published: April 15, 1977
Released on J-STAGE: July 21, 2010
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Yuichi INOUE, Kunio HAMADA, Hozumi IKEDA, Hironobu OCHI, Kazuo HASHI, ...
1977 Volume 26 Issue 4 Pages
259-262
Published: April 15, 1977
Released on J-STAGE: July 21, 2010
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Shunichi NAKANO, Yoshihisa HASEGAWA, Takeshi IWANAGA, Hiroki KOYAMA, A ...
1977 Volume 26 Issue 4 Pages
263-265
Published: April 15, 1977
Released on J-STAGE: July 21, 2010
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Shigeru MORIUCHI
1977 Volume 26 Issue 4 Pages
266-275
Published: April 15, 1977
Released on J-STAGE: July 21, 2010
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Monitoring of Surface Contamination
Yutaka ANAZAWA, Yoshikazu YOSHIDA, Kentaro MINAMI
1977 Volume 26 Issue 4 Pages
276-283
Published: April 15, 1977
Released on J-STAGE: July 21, 2010
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1977 Volume 26 Issue 4 Pages
A1715-A1266
Published: April 15, 1977
Released on J-STAGE: July 21, 2010
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