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—Development and Radioisotope Productions—
Kazutoshi SUZUKI, Ren IWATA, Kazuhiko TAMATE, Kikuo YOSHIKAWA, Tatsuo ...
1977 Volume 26 Issue 2 Pages
67-73
Published: February 15, 1977
Released on J-STAGE: September 07, 2010
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A system was developed for producing short-lived radioactive substances (
11CO,
11CO
2,
13NN,
13NH
3,
18F
-,
62Zn
2+,
123I
-,
etc.) on a scale enough for clinical use, which could also be used for analyzing them rapidly and for investigating their production methods, with less received dose by workers.
The system enabled us to produce remotely several tens mCi of short-lived radioactive substances readily usable for clinical diagnosis, continuously for radioactive gases,
11CO,
11CO
2 and 13NN,
or repeatedly at short intervals for radioactive aqueous solutions of 13NH
3,
18F
-,
etc. Employing this system, the average received dose per month was reduced considerably.
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Yoshio HOMMA, Yukio MURAKAMI
1977 Volume 26 Issue 2 Pages
74-79
Published: February 15, 1977
Released on J-STAGE: September 07, 2010
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In order to determine the optimum irradiation conditions to produce 123I
for nuclear medical use, excitation curves and thick-target yield curves were measured by means of stacked foil technique for a and 3He
reactions producing 123Xe,
123I,
125Xe
and 130I,
both from natural tellurium. The 123Xe
yields from natural tellurium are too low for routine production. However, by bombarding 76.5% isotopically enriched 123Te
target with 30 MeV 3He
particles, 724μCi/μAh of123I
would be obtained, whereas the level of 125I
contaminat would be about 0.14%.
130Te
contaminant in enriched 123Te
target produces 123I α
and 3He
bombardment, although it has not been reported in the past. The 130I
contaminant can be easily eliminated.
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—Preparation of 125I-labelled Human·C-Peptide—
Nobuhiko NAKAZAWA, Kentaro MAKI, Hiroshi OGAWA, Osamu IKEDA
1977 Volume 26 Issue 2 Pages
80-85
Published: February 15, 1977
Released on J-STAGE: July 21, 2010
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125I-
labelled human·C-peptide was prepared by chloramin T method, enzymic method and active ester method, respectively.
Using respective 125I-
labelled human·C-peptides in human proinsulin·C-peptide RIA, we compared the binding (
B0/
T%)
to antibody, displacement by standard human·C-peptide, the recovery test and stability. The usable 125I-
labelled antigen for human proinsulin·C-peptide RIA could be prepared by chloramin T method and enzymic method which labelled 125I
to tyrosyl human proinsulin connecting peptide, and active ester method which conjugates 125I-
labelled active ester to human proinsulin connecting peptide.
The difference among those 125I-
labelled antigens was not observed in displacement (
B/
B0%)
by standard human·C-peptide and the recovery test. In the case of constant preparation of 125I-
labelled antigen for RIA, the enzymic method was the best from the viewpoint that reaction ratio is stable and stability of B0/
T%
is good.
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Atsushi ANDO, Masazumi TAKESHITA, Itsuko ANDO, Tatsunosuke HIRAKI, Kin ...
1977 Volume 26 Issue 2 Pages
86-91
Published: February 15, 1977
Released on J-STAGE: September 07, 2010
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Subcellular distribution of67Ga
was quantitatively determined to evaluate the role of lysosome in accumulation of 67Ga
in malignant tumor tissue and liver. The following animals and transplanted tumors were used: rats implanted with Yoshida sarcoma and hepatoma AH109A; mice implanted with Ehrlich tumor.
67Ga-
citrate were injected to the rats intravenously and to the mice intraperitoneally. Ten minutes to 48 hours after the administration of 67Ga-
citrate, the animal were sacrificed, and the tumor tissues and liver were excised. Subcellular fractionation of tumor tissues and livers were carried out according to the method of Hogeboom and Schneider. Radioactivity of each fraction was counted by a well type scintillation counter, and protein of each fraction was measured according to Lowry's method.
In Yoshida sarcoma and Ehrlich tumor, most of the radioactivity was localized in the supernatant fraction, and small amount of radioactivity was localized in the mitochondrial fraction (lysosome contains in this fraction) . But in the liver, most of the radioactivity was concentrated in the mitochondrial fraction and the radioactivity of this fraction was increased with the passage of time after administration. Twenty-four hours later, about 50% of total radioactivity was accumulated in this fraction. In the case of hepatoma AH109A, radioactivity of mitochondrial fraction was increased with the passage of time after administration, and about 30% of total activity was concentrated in this fraction at 24 hours after administration. From these results it is concluded that lysosome does not play an important role in the tumor concentration of 67Ga
and lysosome plays an important role in the liver concentration of 67Ga.
In the case of hepatoma AH109A it is presumed that lysosome plays considerably important role in the tumor concentration of 67Ga,
hepatoma AH109A having some nature of liver.
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Rikusei KOHARA
1977 Volume 26 Issue 2 Pages
92-94
Published: February 15, 1977
Released on J-STAGE: July 21, 2010
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Tomoo SAITO, Yumiko NISHIYAMA, Kazuo WATANABE, Naotake MORIKAWA
1977 Volume 26 Issue 2 Pages
95-97
Published: February 15, 1977
Released on J-STAGE: July 21, 2010
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Katsumi IKEI, Yutaka SUZUKI, Hidemi WATANABE, Masao TAKAHASHI, Masahir ...
1977 Volume 26 Issue 2 Pages
99-101
Published: February 15, 1977
Released on J-STAGE: July 21, 2010
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Yoshio YONAHARA, Yoshiko TAKAHARA, Yoshizo SASAKI, Hiroshi KIRIMURA, A ...
1977 Volume 26 Issue 2 Pages
102-105
Published: February 15, 1977
Released on J-STAGE: July 21, 2010
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Yutaka SUZUKI, Hidemi WATANABE, Shinya OKABE, Haruo TOMODA
1977 Volume 26 Issue 2 Pages
106-108
Published: February 15, 1977
Released on J-STAGE: July 21, 2010
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Akira TADA, Akio KUBOTA, Masami SUGIHARA, Takatoshi MICHIGISHI, Ikuro ...
1977 Volume 26 Issue 2 Pages
109-111
Published: February 15, 1977
Released on J-STAGE: July 21, 2010
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Tatsuya TSUCHIDA, Toshiyuki NAKAJIMA
1977 Volume 26 Issue 2 Pages
112-114
Published: February 15, 1977
Released on J-STAGE: July 21, 2010
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Takashi SHISHIDO
1977 Volume 26 Issue 2 Pages
115-125
Published: February 15, 1977
Released on J-STAGE: July 21, 2010
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Monitoring of External Radiation (1)
Kenkaro MINAMI, Masao OSHINO
1977 Volume 26 Issue 2 Pages
126-138
Published: February 15, 1977
Released on J-STAGE: July 21, 2010
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1977 Volume 26 Issue 2 Pages
A1699-A1250
Published: February 15, 1977
Released on J-STAGE: July 21, 2010
JOURNAL
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