RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
Volume 23 , Issue 11
Showing 1-14 articles out of 14 articles from the selected issue
  • Yoshiaki MARUYAMA, Teruo MANRI
    1974 Volume 23 Issue 11 Pages 609-613
    Published: November 15, 1974
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    The extractability of the nuclides 38Cl and 82Br from the irradiated potatoes was investigated using the extractants such as water, sodium hydroxide solution and nitric acid. The irradiated samples were extracted by shaking for 2 min with the extractants.
    The extraction yields of38Cland82Brincreased with the elevation of temperature and with the addition of carriers. Among the extractants used, nitric acid was found to be the most effective for the extraction of38Cland82Br.When extractions were performed at 90°C with nitric acid containing carriers, almost 100% of these nuclides were found to be extractable.
    These experimental results were utilized for the activation analysis of chlorine and bromine in potato. It was found that chlorine and bromine tended to be concentrated in stem, leaf and tuber in the decreasing order.
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  • Itsuo YAMAMOTO, Rikushi MORITA, Toru MORI, Tsutomu SAKAMOTO, Kanji TOR ...
    1974 Volume 23 Issue 11 Pages 614-619
    Published: November 15, 1974
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    A fundamental and clinical comparative study of three kinds of99mTc-labeled phosphorus compounds—99mTc-polyphosphate, 99mTc-pyrophosphate and99mTc-diphosphonate (EHDP) —, was made and the diagnostic efficiency of these agents in metastatic bone tumors is discussed.
    Paperchromatographic study revealed the labeling efficiency of99mTc-poly phosphate was 70 percent which was worse than those of99mTc-pyrophosphate and99mTc-di phosphonate in both of which more than 95 percent of99mTcwas labeled.
    A comparison between99mTc-pyrophosphate and99mTc-diphosphonate in the rat organs 3 hours after i.v. administration revealed that the distribution of99mTc-diphosphonate was less than that of99mTc-pyrophosphate in the soft tissue such as the blood or the muscle. The spine/blood uptake ratio was 9.3 in99mTc-diphosphonate and 5.0 in99mTc-pyrophosphate.
    The disappearance of the radioactivity from the blood in human was essentially the same in99mTc-pyrophosphate and99mTc-diphosphonate which were faster than that in99mTc-polyphosphate.
    Clinically, with99mTc-polyphosphate, the thyroid or the liver was occasionally imaged but was seldom with other two agents. No essential difference was found in bone imaging between99mTC-pyrophosphate and99mTc-diphosphonate.
    Bone scintigram of the metastatic bone tumors taken with these three agents was compared with bone X-ray photo and value for serum alkaline-phosphatase. Of 28 cases of positive scintigram, 9 cases had no abnormal lesions on X-ray photo and 11 cases had negative X-ray lesions and positive scan lesions as well as positive X-ray and scan lesions. All of these scan positive lesions had been strongly suspected of bone metastases by symptoms and histories but not proved histologically. In 4 X-ray photo positive cases, the scintigrams were negative. All of these 4 cases were long standing after radiation or hormone therapy and had no symptoms. In 24 scan positive cases, the values for serum alkaline phosphatase were high in 13 cases.
    As was said about85Sr, 87mSr, 18F and other agents, the scintigraphy with99mTc-labeled phosphorus compounds was more useful in early diagnosis of bone metastasis than X-ray examination or value for serum alkaline phosphatase.
    Other skeletal disorders than metastatic bone tumor were not discussed in detail in this paper, but some interesting cases in which bone scintigrams were very useful diagnostics were presented: metastatic calcification in the lung in tertiary hyperpara-thyroidism; metastatic osteogenic sarcoma in the peritoneunt, the lung and the brain; metastatic brain tumor; hydronephrosis.
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  • Ikuro TATSUNO, Takatoshi MICHIGISHI, Sotoe KATO
    1974 Volume 23 Issue 11 Pages 620-627
    Published: November 15, 1974
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    Fundamental and clinical investigation on the liver scanning were carried out with99mTc-Sn-colloid (99mTc-Sn-C) and 99mTc-phytate (99mTc-P), both of which were made into kits by Daiichi Radioisotope Labs., Ltd. for the non-electrolytic method.
    In the preparing point of view, 99mTc-P seems to be prepared more simple and stable than99mTc-Sn-C. The labelling yields of both agents were about 99% and, also their particle sizes were uniform. In the liver scintigrams, any remarkable differences between both agents were not observed in shape, size, and RI distribution of the liver and any background images disturbing to read the scintigrams were not observed.
    The splenic image with99mTc-Sn-C was more clearly delineated than that with99mTc-P. Generally, the RI ratio of spleen vs. liver (right lobe) (Sp/R) with99mTc-Sn-C was greater than that with99mTc-P irrespective of each group of liver diseases. Especially, in the liver cirrhosis, Sp/R ratio was remarkably high, and this fact is very important for its scan diagnosis. In the liver scintigrams, the degree of splenic visualization with99mTc-P being quite similar to that with198Au-colloid, the scintigram with99mTc-P seems convenient as diagnostic criteria.
    In the point of correct diagnosis for liver cirrhosis, 99mTc-Sn-C was superior to99mTc-P.
    Liver scintigrams obtained with99mTc-Sn-C and99mTc-P respectively are useful for the differential diagnosis of the upper abdominal masses, observation of therapeutic course of various liver diseases, decision on the existence of operative indication and its method. No side effects were observed in both agents, 99mTc-Sn-C and99mTc-P.
    We came to a conclusion that both99mTc-Sn-C and99mTc-P are effective scanning agents, giving scintigrams of excellent quality with very little internal radiation exposure and fairly simple kit operation.
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  • Akiko KUBODERA, Susumu TSURUFUJI
    1974 Volume 23 Issue 11 Pages 628-634
    Published: November 15, 1974
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    A large number of radioactive diagnostic agents have been used only for the purpose of clinical diagnosis. In the present experiments, radioactive rose bengal and radiogold colloid were used as radioactive diagnostic agents to determine the mechanism of liver damages caused byCCl4, and with the purpose of screening of the drugs functionally alleviating liver damage caused byCCl4.Rats were used as the experimental animals. The determination of liver uptake ratio of radioactive rose bengal in the liver, the changes of liver uptake of radioactive rose bengal and radiogold colloid among the animal groups treated byCCl4, the uptake fluctuations when treated by the different levels of curies and specific activities were included in this study. The liver uptake of radioactive rose bengal was significantly lower in the groups treated withCCl4 than that in control. A decrease in the uptake was proportional to the doses of CCl4, but was not correlated with the changes of hepatic blood flow. The administration ofCCl4in the low doses which caused no remarkable histological changes induced a decrease in liver uptake of radioactive rose bengal. Since the values of serum transaminase were comparable with that of control at the levels, the liver function seemed to be highly sensitive to the uptake of radioactive rose bengal.
    The influence of various materials was studied after theCCl4treatment and the liver uptake of radioactive rose bengal was examined. GOT and GPT values were determined along with histological studies. On the other hand, similar studies above mentioned were also carried out in the groups pretreated with the materials for ten days. Potato kallikrein inhibitor (PKI) and methyl met hionine sulfonium chloride inhibited the decrease in liver uptake of radioactive rose bengal as compared with that of animals treated withCCl4alone. Histological studies also revealed the inhibition of appearance of fat droplet in the liver.
    These results indicate that the method utilizing radioative rose bengal appears to be useful as a primary screening method to examine the effectiveness of the materials against the liver. The fact that the administration of PKI inhibited the lowering of liver function and the appearance of fat droplet in the damaged liver caused byCCl4might indicate the participation of the kinin system.
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  • Kikuo MACHIDA, Hiroshi YASUKOCHI, Motoo OHSHIMA, Kimiichi UNO
    1974 Volume 23 Issue 11 Pages 635-639
    Published: November 15, 1974
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    As previously reported, we record lung scans in the paper tapes with the routine scintigrams simultaneously. By using these tapes we processed the scintigrams with TOSBAC 40 TIME SHARING SYSTEM electronic computer. The anterior and posterior scintigrams were recorded with the Toshiba scintiscanner (φ: 3 in.) with the 37 hole collimator (the distance of focus: 10 cm), after intravenous administration of 131I-MAA to the sitting patient.
    The quality of the images was compared among original scintigram, the nonsmoothed digital printed by the computer, and the smoothed digital. By smoothing the original, the image of lung scans was improved remarkably and appeared to be useful in clinical use. The computer displayed each point in 10 different marks according to the number of counts, which enabled us to recognize the radioactivity of the points semiquantitatively.
    Furthermore the integral counts of both lung fields were calculated. The normal anterior values were 43.2±4.9% (N=10) in the left and 56.8±4.9% in the right; posterior values were 46.7±2.7% (N=6) in the left and 53.3±2.7 in the right.
    The ratio of each level of the counts between left and right lung was also compared. All these data were obtained very easily by the computer and expected to be useful clinically.
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  • Masao KANEKO, Tsuneo SASAKI, Michiko WATANABE, Tsuneharu FUJITA, Yoshi ...
    1974 Volume 23 Issue 11 Pages 640-645
    Published: November 15, 1974
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    Lungs are obviously most strongly influenced organs by respiration, because of their own movement.
    99mTc-MAAis easily obtained by only adding sterilized99mTc-pertechnetate into the MAA vial containing MAA and stannous chloride in acetate buffer.
    By injecting this99mTc-MAA, multi-directional lung scintiphotos, that is, frontal, both laterals and posterior view of the lungs, are obtainable safely and rapidly, even during the breath holding, resulting in good clinical information by the better quality of the images.
    Sixty-nine cases are subjected to study. Group I consists of 22 cases of lung cancer and other cancers which have invaded hilar lymph nodes. Group II, 16 cases of postoperative breast cancer to be examined radiation effect upon the apex. Group III, 23 cases of mitral stenosis, congenital heart disease and so on. Group IV, 8 cases of aortitis syndrome and others.
    Exactly knowing the distribution of99mTc-MAAperfusion in the lungs, elucidation of pathophysiology of these diseases is greatly supported.
    In the Group II, “Apex View” is newly considered for better observation of apical blood flow. This technique is performed by placing the scinticainera head facing to the back of the patients posteriorly with 30°of inclination. Before and after irradiation therapy, this technique is applied to the investigation of a more innocuous method of irradiation to the supraclavicular region.
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  • Yasushi TAKAGI, Shin-ichi KUSAKARI, Shiro KANESEKI
    1974 Volume 23 Issue 11 Pages 646-648
    Published: November 15, 1974
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Michiyasu SUGII, Hiroshi MIURA, Hiroshi YAMASHITA
    1974 Volume 23 Issue 11 Pages 649-651
    Published: November 15, 1974
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Atsushi ANDO, Kinichi HISADA, Tatsunosuke HIRAKI, Itsuko ANDO, Sigeru ...
    1974 Volume 23 Issue 11 Pages 652-655
    Published: November 15, 1974
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Atsushi ANDO, Koh SAKAMOTO, Takashi NAKANISHI, Masanobu SAKANOUE, Kini ...
    1974 Volume 23 Issue 11 Pages 656-658
    Published: November 15, 1974
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Osamu NISHINO
    1974 Volume 23 Issue 11 Pages 659-666
    Published: November 15, 1974
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • A. IINUMA
    1974 Volume 23 Issue 11 Pages 667-669
    Published: November 15, 1974
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Shun-ichi MIYASAKA
    1974 Volume 23 Issue 11 Pages 670-680
    Published: November 15, 1974
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • 1974 Volume 23 Issue 11 Pages A1483-A1036
    Published: November 15, 1974
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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