RADIOISOTOPES

Behavior of ¹⁴C-Labeled Polymeric 2-Methyl-5-Vinyl-N-Allylpyridinium Bromide in the Nickel Plating Solution Adsorption on or Incorporation in the Nickel Plate

Takeshige NAKABAYASHI, Yasunori ARISATO, Masayuki HAMADA

1975Volume 24Issue 2 Pages 83-87
Published: February 15, 1975
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.24.2_83

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In order to examine the behavior of polymeric pyridinium salts as effective corrosionresistant reagents in nickel-plating, ¹⁴C-labeled polymeric 2-methyl-5-vinyl-N-allylpyri-dinium bromide was prepared. The amounts of the polymer which was incorporated in nickel electrodeposited from a nickel plating solution were determined by measuring its radioactivity, It was found that the polymer was incorporated undoubtedly in the nickel electrodeposit, and the amounts of its incorporation were dependent on both current density and concentration of the polymer in the plating solution. The amounts of the polymer adsorbed on the same nickel plate simply immersed in the plating solution were very small compared with those o f incorporation.

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The Formation of ³⁵S Labeled Dithiocarbamate by the Reaction of Thiurumidisulfide with Inorganic Sulfide-³⁵S

Toshiro SATO

1975Volume 24Issue 2 Pages 88-92
Published: February 15, 1975
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.24.2_88

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The decomposition reaction of thiurumdisulfide with ³⁵S labeled inorganic sulfide ion and the distribution of ³⁵ in the products were investigated.
No radioactivity was found in the dithiocarbamate in the reaction at 30°C. This result shows that the decomposition of thiurumdisulfide is caused by the nucleophilic attack of sulfide ion on a -S-S- bond as is generally accepted. In the reaction at 80°C ³⁵S labeled dithiocarbamate was yielded, and its radioactivity was increased by additional heating of the reaction mixture. The incorporation of ³⁵S into the product was explained in terms of the isotope exchange reaction with ³⁵SH-.
The corresponding ³⁵S labeled dithiocarbamates were isolated from the reaction mixtures.

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Effects of Age and Growth on Macromolecular Biosynthesis in Salmon Brain

Shigemitsu TANO, Soichiro SHIRAHATA

1975Volume 24Issue 2 Pages 93-96
Published: February 15, 1975
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.24.2_93

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Syntheses of DNA, RNA and protein in the brain of Pacific salmon, Oncorhyncus nerka, were compared among different age groups of fish. Marked differences in the ratio of DNA and RNA to protein were observed. Synthetic activity of RNA measured by the incorporation of ³H-uridine in the brain decreased according to the increase of age. Ratios of DNA/protein, RNA/protein and the synthetic activity of RNA seemed partly dependent on their body weight.

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A Simplified Radioimmunoassay of Adenosine-3': 5'- Monophosphate (Using Dextran-Coated Charcoal)

Yoshiki KATOH, Junichi TAKEZAWA, Morio SUZUKI, Akira KUNINAKA, Hiroshi ...

1975Volume 24Issue 2 Pages 97-103
Published: February 15, 1975
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.24.2_97

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Dextran-coated charcoal was proved to be able to separate free cAMP from antibodybound cAMP. Only free cAMP was adsorbed on dextran-coated charcoal within 1 min after contacting the charcoal and reaction mixture of cAMP and anti-cAMP-plasma, and most of antibody-bound cAMP was not adsorbed within 4 min after contacting. The data obtained were confirmed to be almost equal to the data of another experiment using cellulose ester filter separation technique. Thus, dextran-coated charcoal could be employed to simplify the radioimmunoassay of cAMP.

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Relationship between Strains of Tumor-bearing Animals and the Tumor Affinity of ¹⁶⁹Yb and ⁶⁷Ga

Atsushi ANDO, Kinichi HISADA, Tatsunosuke HIRAKI, Itsuko ANDO, Toshimi ...

1975Volume 24Issue 2 Pages 104-108
Published: February 15, 1975
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.24.2_104

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It is a well-known fact that ytterbium-169 is a strong bone seeking element. We already reported that this element concentrated in nonosseous tumor tissues and the tumor affinity of this element was stronger than that of gallium-67 in our previous experiment using Yoshida sarcoma-bearing rats. Ytterbium-169 citrate and gallium-67 citrate were compared in four strains of tumor-bearing rats and mice. The uptake rate of ytterbium-169 in tumor tissues was much larger than that of gallium-67 in Ehrlich cancer-bearing mice, but these values of ytterbium-169 were slightly smaller than those of gallium-67 in Yoshida sarcoma-bearing rats, Walker carcinosarcoma 256-bearing rats and sarcoma 180-bearing mice. Tumor to organ ratios of ytterbium-169, which were most important for tumor scanning agents, were much larger than those of gallium-67 in all four strains except tumor to bone ratio of ytterbium-169. From the above-described facts, it was shown that ytterbium-169 citrate had stronger tumor affinity than gallium-67 citrate and the tumor affinity of ytterbium-169 citrate was similar in these four strains of tumor-bearing animals.

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Affinity of ¹⁶⁷Tm for Malignant Tumor and Bone

Atsushi ANDO, Kinichi HISADA, Koh SAKAMOTO, Yoshiaki SHIROTA

1975Volume 24Issue 2 Pages 109-114
Published: February 15, 1975
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.24.2_109

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¹⁷⁰Tm-citrate has recently been reported to concentrate in nonosseous tumor tissue in animal study. We produced ¹⁶⁷Tm by ¹⁶⁸Yb (r, n) ¹⁶⁷YbEC→¹⁶⁷Tm reaction which had suitable property for tumor scanning. To investigate whether ¹⁶⁷Tm produced by this method has strong tumor affinity, ¹⁶⁸Tm-citrate was intravenously injected to the rats subcutaneously transplanted Yoshida sarcoma. And the distribution of¹⁶⁸Tm in the body was determined at 3, 24 and 48 hours after administration.¹⁶⁷Tm-citrate (carrier free) and¹⁶⁷Tm-citrate (containing Tm of 5μg) had the same strong tumor affinity as¹⁷⁰Tm-citrate in the previous experiment, but¹⁶⁷Tm-citrate (containing Tm of 50μg) did not have the tumor affinity.¹⁶⁷Tm-citrate (carrier free) and¹⁶⁷Tm-citrate (containing Tm of 5μg) had the considerably strong bone affinity, but it was not concluded that¹⁶⁷Tm-citrate was a more excellent bone scanning agent than ^99mTc-labeled phosphonate.¹⁶⁷Tm-citrate (carrier free) had the considerably strong affinity for inflammatory tissue as¹⁶⁹Yb-citrate had. From above described results, it was clearly shown that¹⁶⁷Tm-citrate produced in our new method had strong tumor affinity.

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A Subtraciton Scintigraphy Using ¹⁹⁷HgCl₂ and ¹³¹I-RISA for the Diagnosis of Lung Cancer

—Comparison between Whole Body Scanner and Scinticamera with a Digital Processor—

Tadashige FUJII, Hisakata KANAI, Shozo KUSAMA, Masaomi TAKIZAWA

1975Volume 24Issue 2 Pages 115-120
Published: February 15, 1975
Released on J-STAGE: September 07, 2010

DOIhttps://doi.org/10.3769/radioisotopes.24.2_115

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As tumor imaging, the subtraction scintigraphy using¹⁹⁷HgCl₂and¹³¹I-RISA was performed with a whole body scanner or a scinticamera coupling to16K words digital minicomputer. The subtraction image was found to be more available than the conventional image of¹⁹⁷HgCl₂ for the image quality enhancement. In this method, the part of nonspecific concentration on the image of¹⁹⁷Hg was erased, so that hyperfixation of ¹⁹⁷Hg in the metastatic focus of the mediastinum was more clarified. The subtraction scintigraphy with both a scinticamera with digital processing unit and a whole body scanner had respective merits. In the former, the time necessary for storing the image was shorter and the operation of subtraction was performed more exactly and easily. Therefore, the subtraction image obtained had a good contrast. In the latter, the subtraction image obtained had a good resolution.

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Usefulness of Brain Scanning in Diagnosis of Acousitc Neurinoma

Hirofumi MORI, Toshio MAEDA, Yutaka SUZUKI, Kinichi HISADA

1975Volume 24Issue 2 Pages 121-123
Published: February 15, 1975
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.24.2_121

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Serum Gastrin Levels for Various Liver Disearses

Yoshiaki TAKAOKA, Aki KATAYAMA

1975Volume 24Issue 2 Pages 124-126
Published: February 15, 1975
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.24.2_124

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Diagnosis of Pulmonary Function by Radioisotopes

Masao KANEKO

1975Volume 24Issue 2 Pages 127-136
Published: February 15, 1975
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.24.2_127

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Liquid Scintillation Counting Technique (II)

Basic Knowledge for the Utilization (2)

Hiroaki ISHIKAWA

1975Volume 24Issue 2 Pages 137-148
Published: February 15, 1975
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.24.2_137

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[title in Japanese]

1975Volume 24Issue 2 Pages A1507-A1060
Published: February 15, 1975
Released on J-STAGE: July 21, 2010

DOIhttps://doi.org/10.3769/radioisotopes.24.2_A1507

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