RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
Volume 24 , Issue 10
Showing 1-17 articles out of 17 articles from the selected issue
  • Hiroshi SHIBATA
    1975 Volume 24 Issue 10 Pages 679-683
    Published: October 15, 1975
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    This study was undertaken to compare the absorption and excretion of inorganic zinc, cadmium and mercury in the gastrointestinal tract using65Zn.109Cd and203Hg.
    A single dose of65Zn, 109Cd or203Hg was administered orally or injected intravenously to investigate the distribution, excretion into bile and excretion into feces or urine. Absorption and excretion through the gastrointestinal tract of mice were studied by the tied loop method. Every eight mice or rats were used to measure the radioactivity in sample with a scintillation counter.
    Most of the orally administered65Zn, 109Cd or203Hg was excreted into feces and was less absorbed from the gastrointestinal tract, respectively. Absorption rate in the gastrointestinal tract was as follows: 203Hg>65Zn>109Cd. Intravenously injected65Zn, 109Cd or203Hg was excreted into the gastrointestinal tract through the gastrointestinal wall and bile duct, respectively. Excretion rate in the gastrointestinal tract was as follows: 65Zn>203Hg>109Cd. When comparing the absorption and excretion in each gastrointestinal tract divided into 10 parts, 65Zn, and109Cd were relatively well absorbed from the upper and lower part of small intestine and excreted into the upper, middle, lower part.203Hg was relatively well absorbed from the upper, lower part of small intestine and excreted into the stomach and the caecum. The major accumulated organ of absorbed65Zn, 109Cd or203Hg was the pancreas and liver, liver and kidney, kidney and liver, respectively.
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  • Yasuji HOJO, Yukio SUGIURA, Hisashi TANAKA
    1975 Volume 24 Issue 10 Pages 684-688
    Published: October 15, 1975
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    Removal of203Hg-labeled organomercurials, bound to sulfhydryl groups of hemoglobin, by various chelating agents was investigated by the use of equilibrium dialysis. Organomercurials employed were chlormerodrin, met hylmercury, ethylmercury and phenylmercury compounds. The higher and more specific effects of the sulfur-ligands such as penicillamine and glutathione on removal of organomercurials were found as compared with those of the nitrogen-ligands such as EDTA, glycine and polymethylenediamines. The linear correlation was observed between the degree of organomercury elimination from hemoglobin and the stability constant (log K1) of 1: 1 organomercury complex in both the sulfur- and nitrogen-ligand systems, and at the same value of log K1, the elimination-effect of sulfur-ligands was extremely greater than that of nitrogenligands. The relationship between the average percentage of removal and the Taft's polar substituent constant of organic moiety of the metal was also linear among the organomercury compounds other than chlormerodrin. The average removal percentage by sulfur-ligands increased in the order, ethylmercury>methylmercury>phenylmercury, while that by nitrogen-ligands was not different among organomercurials investigated. In addition, the direct ligand-exchange reaction between hemoglobin-SH and the ligand coordinating-atom (S or N) against organomercurials rather than SN2reaction via the ternary complex, hemoglobin-S-RHg-ligand, is postulated.
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  • Keiziro KIMURA, Sizuo HASEGAWA, Toru MATSUMOTO, Noboru ARIMIZU
    1975 Volume 24 Issue 10 Pages 689-694
    Published: October 15, 1975
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    Using133Xe, a xenon lung function unit (Model 36-001, Nuclear Associates, INC.) and a large area scintillation camera (the effective field, 34 cm in diameter), combined with computer analysing technique (TOSBAC C3400 Model 31), the regional pulmonary function was evaluated.
    Regional clearance half time (T1/2), time constant (τ) and ratios of disappearance constant (λit) were calculated from wash out curves for equilibrated gas in the steady state.
    These dynamic indices were compared with regional ventilation indices (Vi) and perfusion indices (Qi) obtained by a single breath method.
    In a steady state method, the late part of
    133Xe wash out curves was affected by radioactivity in chest wall, mediastinum and great vessels.
    We compared wash out curves of equilibrated gas during normal breathing with those during hyperventilation and those of perfused gas during normal breathing.
    These data indicated that the late part (after 4 minutes) of wash out curves was dependent on radioactivity in tissue without air space.
    For calculating the accurate values of dynamic ventilation, correction was made for the errors by the computer.
    In our method using 5-10 mCi133Xe, each values in lung field, arbitrary divided into 24 zones, can be measured with time interval for 8 seconds.
    Dynamic indices as well as static indices in 7 healthy subjects tended to increase from upper to lower zone.
    The differences in each zones and standard errors of the data by the steady state method were smaller than those by the single breath method.
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  • Tadamasa YASUNAGA, Masayasu KAN, Masanori MATSUMOTO, Kenshi KATAYAMA
    1975 Volume 24 Issue 10 Pages 694-699
    Published: October 15, 1975
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    Fundamental and clinical investigation were carried out with99mTc-MAA which was prepared in our laboratory using“Techne-MAA-Kit”. Radiochemical purity of99mTC-MAA by paper chromatography was about 98% and stable after tagging during 3 hours of observation. In addition, radioactivity over the lung after injection was very high by linear scan.
    One hundred and seven cases were subjected to study. All scintiphotos were taken by means of anterior, posterior, left and right laterals projection using gamma camera. Especially, in 43 cases of lung cancer, detectability of perfusion deficits in each projection was investigated in comparison with the roentgenograms. As a result, it was found that perfusion deficits in located segmental lesion were frequently undetected by the anterior or posterior scintiphotos but were well defined in the lateral views. Multiple view are therefore necessary in the case of routine examination and the application of99mTc-MAA is very appropriate in order to save a time for us.
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  • Kazufumi KIMURA, Yoshio TAKAHASHI, Yasuhiko HAMANAKA
    1975 Volume 24 Issue 10 Pages 700-706
    Published: October 15, 1975
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    Blood pool scintigrams of heart and major vessels were performed in 22 cases using99mTc-HSA and a scintillation camera. In a case of idiopathic pericarditis, an enlargement of zone of decreased activity between heart and the lungs and/or liver was observed.
    In a case of congestive heart failures with X-ray findings of cardiac enlargement, blood pool scintigrams were useful for the examination of pericardial effusion. In a case of aortic aneurysm and ventricular aneurysm, the lesions were clearly demonstrated. It was useful for the differential diagnosis between aneurysms and tumors. Using ECG-gated scintigram, the shape of cardiac chambers in systolic and diastolic phases were obtained. From these observations, the existence of ventricular aneurysms in cases of myocardial infarction were easily detected. In conclusion, blood pool scintigrams with99mTc-HSA were non-invasive and easy to perform. It was demonstrated that this technique were useful for the differential diagnosis of cardiomegalies or major blood vessel diseases.
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  • Tamio ABURANO, Yutaka SUZUKI, Kinichi HISADA, Masamichi MATSUDAIRA
    1975 Volume 24 Issue 10 Pages 707-711
    Published: October 15, 1975
    Released: September 07, 2010
    JOURNALS FREE ACCESS
    Since some years ago, radioisotope angiography of the liver has been mainly used to evaluate the vascular state of focal hepatic lesions. With both scintillation camera and a short half life radionuclide, it became possible to separate the distribution of blood supply to the liver into arterial and portal components. On the other hand, it is known that the relative distribution of blood supply to the liver is altered in various diffuse hepatic diseases. In the present study, a region of interest (ROI) angiohepatogram was obtained with intravenous injection of 10mCi of89mTc-Sn-colloid and a data processing system. Furthermore, the ratio of hepatic arterial blood flow volume to total hepatic blood flow volume was calculated according to Ueda's method, and the correlation of this calculated ratio and the degree of extrahepatic distribution of99mTC-Sn-colloid (spleen to liver, and bone marrow to liver activity ratio) was examined.
    The obtained results are as follows:
    1) Most of liver cirrhosis and Banti's syndrome showed the increased hepatic arterial blood flow ratio (liver cirrhosis: 43.5±9.5%, Banti's syndrome 48.8±4.9%) in contrast with 18.1±4.6% in normal case, and its ratio showed much higher values in the presence of portal hypertension manifestations (esophageal varix and ascites) .
    2) The hepatic arterial blood flow ratio showed increased values in the case of markedly increased extrahepatic activity, e. g. liver cirrhosis, and the correlation of the ratio and extrahepatic activity degree of99mTc-Sn-colloid was significant statistically.
    From these results, a region of interest (ROI) angiohepatogram was supposed to be useful for the prediction of the henaodynamic change as well as the improvement of diagnostic accuracy with radioisotope in diffuse hepatic disease, especially liver cirrhosis. Moreover, the hemodynamic change of liver, especially the reduction of the effective hepatic blood flow volume via the portal vein was considered to be closely concerned in the mechanism of increased extrahepatic activity of RI colloid in dffuse hepatic disease.
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  • Nagao IKEDA, Yasuko TAKAHASHI, Kan KIMURA
    1975 Volume 24 Issue 10 Pages 712-714
    Published: October 15, 1975
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Kunio TAKEI, Hitoshi HAGIWARA
    1975 Volume 24 Issue 10 Pages 715-718
    Published: October 15, 1975
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Itsuo KUROBANE, Hikoyuki YAMAGUCHI
    1975 Volume 24 Issue 10 Pages 719-721
    Published: October 15, 1975
    Released: July 21, 2010
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  • Hiroshi SHIBATA
    1975 Volume 24 Issue 10 Pages 722-723
    Published: October 15, 1975
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Tadashi NOZAKI
    1975 Volume 24 Issue 10 Pages 724-732
    Published: October 15, 1975
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Hiroshi YASUKOCHI
    1975 Volume 24 Issue 10 Pages 733-736
    Published: October 15, 1975
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Hiroshi YASUKOCHI
    1975 Volume 24 Issue 10 Pages 737-740
    Published: October 15, 1975
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Masayasu NOGUCHI
    1975 Volume 24 Issue 10 Pages 741-744
    Published: October 15, 1975
    Released: July 21, 2010
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  • Masayasu NOGUCHI
    1975 Volume 24 Issue 10 Pages 745-748
    Published: October 15, 1975
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • Hiroaki ISHIKAWA
    1975 Volume 24 Issue 10 Pages 748-753
    Published: October 15, 1975
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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  • 1975 Volume 24 Issue 10 Pages A1571-A1121
    Published: October 15, 1975
    Released: July 21, 2010
    JOURNALS FREE ACCESS
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