The chemical effects of the isomeric transitions of 127mTe and 129mTe have been investigated in solid ammonium and potassium halo-tellurates (IV), tellurium dioxide, and tellurous acid, and also in aqueous solutions of telluric acid containing halide ions. Almost no daughter nuclides were found in the tellurium (VI) fraction in the case of solid halo-complex salts, tellurium dioxide, and tellurous acid. For aqueous solutions and ammonium fluoride solutions of telluric acid, however, 60-70% of the daughter nuclides were found in the tellurium (IV) fraction after the isomeric transition. In the other solutions, more than 90% of the daughter nuclides were found in the tellurium- (IV) fraction.
Radionuclide images by a scintillation camera are blurred mainly due to a low resolution of a detector itself and random incidence of γ-rays upon the camera. So it seems that the correction of radionuclide images might play an important role in the improvement of diagnosis based on radionuclide images. Scintillation camera data digitized by the data processing system CDS-4096 which was on-line connected with our scintillation camera (Pho-Gamma III) were off-line processed using FACOM-230/35 and NEAC-2230 computers installed at the data processing center in Kanazawa University. Processed results were printed out by symbols of a lineprinter or punched out on paper tape. Moreover, the result on paper tape was fed back to CDS-4096 through a tapereader and was displayed on the cathode ray tube. In printing out of a lineprinter, the image size was transformed to the real size and the image contrast was increased by superposing multiple symbols of a typewriter. And the distortion of image induced by non-uniformity of sensitivity of a detector was corrected by the data of the distribution of sensitivity checked in every time of an organ scintigraphy, using the scanning unit of241Am band source. Also, we always carried out smoothing in order to reduce a statistical fluctuation before enhancing the organ contour and defects in the organ. In this smoothing, the weight coefficient matrix consisting of simple integers was applied. Then the following programs were studied. The organ contour was obtained by calculating differences of counts among each point and its surrounding points. Multiple chosen level plotting of threshold was used in order to recognize defects. Several levels were chosen from 100 threshold levels of 1% degree and were plotted with superposing. In the image processed by such a method, defects could be detected quite apparently and their relative position in the organ also was known easily.
Human renal transplantation has made it possible to ameliorate anemia being observed in most cases of chronic renal failure. Ferrokinetic studies were carried out on 8 of 9 patients undergoing renal homotransplantation during the past 5 years (at our department) . Before and after the transplantation, samples were obtained to clarify the pathogenesis of the anemia associated with chronic renal failure and its subsequent recovery. Ferrokinetic studies of pre-transplant revealed the ineffective erythropoiesis and hemolysis. After the successful renal transplantation, almost all the ferrokinetic data returned to normal in accordance with the improvement of ineffective erythropoiesis and hemolysis, thus being considered that the grafted kidney could produce erythropoietin which stimulated the exhausted erythropoiesis. However, complete amelioration of the anemia could not be observed in the case of immunosuppressive treatment because of toxic effects of azathioprine on bone marrowcells.
A Res-O-Mat Fe kit is used for an in vitro measurement of the unsaturated iron binding capacity in serum. A resin strip is utilized as adsorbent of residual radioiron after the serum was saturated with radioiron. The unsaturated iron-binding capacity were measured in 53 sera using this kit and Irosorb-test kit, in which a resin sponge is used for adsorbent of radioiron. Results of these tests show a nearly linear correlation. This test is easy to manipulate and the reproducibility test with same sera also was satisfactory. The normal range of unsaturated iron-binding capacity determined using this test kit was as follows.
A comparative study of whole-body autoradio grams was carried out to estimate the effect of difference in the labelling radionuclides on the evaluation of autoradio grams. Two major factors involved are the release of labelling nuclide in the body and the energy intensity of β-rays which influence the resolution in autoradoigram. Three test substances, i.e., 131I-5-chloro-7-iodo-8-hydroxy-quinoline (Quinoform), Quinoform-2, 3, 4-14C and Na131I, were injected to mice, and the whole-body autoradio-grams were compared in detail with each other. The organs to be checked as for the release of131I were found to be the thyroid gland, salivary gland, seminal vesicle, content of the stomach, and skin. Based on these results a discussion was made of the possibility that the release of131I from a compound can be checked in general by a comparative examination of the whole-body autoradiograms with different radionuclides. Additional studies showed that the removal of an emulsion layer from one side of X-ray film is an effective and practical way to improve the resolution in autoradiogram.