RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
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Volume 63, Issue 11
Displaying 1-4 of 4 articles from this issue
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Article
  • A Mass-Production Process of a Highly Pure Medical Use 99mTc from Natural Isotopic Mo(n, γ) 99Mo without Using Uranium
    Katsuyoshi TATENUMA, Koji ISHIKAWA, Akira TSUGUCHI, Yuko KOMATSUZAKI, ...
    2014 Volume 63 Issue 11 Pages 501-513
    Published: November 15, 2014
    Released on J-STAGE: November 28, 2014
    DOIhttps://doi.org/10.3769/radioisotopes.63.501
    JOURNAL OPEN ACCESS
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    A new method to produce highly pure 99mTc of maximum 500Ci(1.85e＋13Bq) per batch from a low specific activity 99Mo made from natural-Mo(n, γ) method is presented in this study.Authors developed a novel procedure to provide 99mTc of high specific activity and purity from 99Mo with a low specific activity obtained by the(n, γ) method. This process named TcMM(technetium master milker) with a new principle found out by the authors involves the selective adsorption of 99mTc onto an activated charcoal column, followed by an elution of 99mTc by warm alkaline solution, and final purification through an alumina column, which would be applicable to routine production of a large amounts of 99mTc from natMo(with 99Mo) within a short processing time and with a low cost.By the experiment using a high radioactivity of 99Mo of 1e＋12Bq levels, a highly pure 99mTc free from natMo(with 99Mo) was obtained in a sterile saline solution within 30 - 50min. as the chemical form of 99mTcO4−, and the average 99mTc milking rate repeated 10 times got 93.5% and the radiochemical purity of the range of 6N - 7N.In the labeling experiments using several radiopharmaceutical kits,99mTc collected from the TcMM process gave the target medicines in a highly radiochemical purity.As the result of investigating the disposition behaviors of the above-mentioned 99mTc-pharmaceuticals using small animals(mouse), 99mTc collected from TcMM gave the same result as it eluted from the conventional 99mTc generator.The findings in this study suggest that the present method using natural isotopic 98Mo(n, γ)99Mo reaction would constitute as an alternative to the Fission Method using HEU to provide 99mTc useful for clinical studies.
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Serial Lectures
Measurements and Evaluations of Air Dose Rates around Fukushima
Basics and Applications of Mössbauer Spectrometry
  • Analysis of Corrosion and Surface Finishing Products on Iron and Steel
    Kiyoshi NOMURA, Yusuke UJIHIRA
    2014 Volume 63 Issue 11 Pages 531-558
    Published: November 15, 2014
    Released on J-STAGE: November 28, 2014
    DOIhttps://doi.org/10.3769/radioisotopes.63.531
    JOURNAL OPEN ACCESS
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    Iron and steel have been used as important materials in industry since the Iron Age. It is well known that iron does not burden severely to the environment of human being. However, iron is easily depleted by corrosion in air atmosphere. The finishing and modification of iron surface have been developed up to now by clarifying the oxidation process and corrosion products of iron. Mössbauer spectrometry becomes a powerful tool for chemical state and layer analysis of various oxides and compounds with the help of X-ray diffraction method, Auger electron, glow discharge optical emission or Rutherford backscattering spectroscopies. Mössbauer analysis of various oxide and phosphate layers on iron and steel, weathering steel and stainless steel are reviewed herewith the fundamental properties of iron oxidation process and the structures of iron oxides and phosphates. In addition, the iron oxide film applied to a solar cell and the stainless steel film to a pH sensor are introduced as application of iron oxides.
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