RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
Volume 19, Issue 6
Displaying 1-9 of 9 articles from this issue
  • Kin-ichi HISADA, Masamichi MATSUDAIRA
    1970Volume 19Issue 6 Pages 263-266
    Published: June 15, 1970
    Released on J-STAGE: September 07, 2010
    JOURNAL FREE ACCESS
    By using the diverging collimator developed by Nuclear-Chicago Corporation together with the scintillation camera it has been made possible to take the entire image of both the lungs as well as both the liver and spleen in a single field of view.
    When the diverging collimator is used, the loss of intrinsic resolution may occur theoretically, due to inclination of the incidence angle of γ- photon to the scintillation crystal. However the result of experiments using line-source phantom showed only the negligible loss of intrinsic resolution. Also over-all resolution including geometric resolution was not deteriorated. The image of scintiphoto taken with the diverging collimator, however, revealed distinct distortion in the depth direction when it was examined using zigzag line phantom. This image distortion does not drastically disturb qualitative interpretation of scinti-image but may bring up a problem when quantitative analysis of scinti-image is desired in future. The over-all sensitivity of the scintillation camera dropped to one-half or one-third when the diverging collimator is used.
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  • 1. In the Normal Human Epidermis
    Yoshio OHSHIMA
    1970Volume 19Issue 6 Pages 267-275
    Published: June 15, 1970
    Released on J-STAGE: September 07, 2010
    JOURNAL FREE ACCESS
    Incorporation of some tritiated amino acids in the normal human epidermis and fetal epidermis was studied by autoradiography. In the cases of methionine, glyeine and histidine silver grains were detected in cytoplasm of the nucleated layers. In the test after 1-2 hour incubation the density of these grains which were scattered all over the layers was greater in the upper spinous layer as compared with the lower layers. In the cases of tyrosine, phenylalanine, valine and leucine, grains were distributed more densely in the lower spinous layer as compared with other layers. After 4-6 hour incubation, all of these amino acids were observed more uniformly in the entire epidermal layers except the horny layer, the labeling being highest in the basal layer. It may be interpreted here, that the incorporation into the upper layers after 1-2 hours is related to enzyme activity or energy of epidermal cell, and that into the lower layers especially basal layer after 4-6 hours to protein synthesis accompanied by celluar proliferation.
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  • Atsushi ANDO, Kin-ichi HISADA
    1970Volume 19Issue 6 Pages 276-281
    Published: June 15, 1970
    Released on J-STAGE: July 21, 2010
    JOURNAL FREE ACCESS
    131I-albumin and 131I-fibrinogen have already been used in clinical scanning of malignant tumors. The mechanism of their affinity for tumors, however, is not sufficiently clear. In order to investigate the mechanism of the accumulation in tumors, experiments were carried out as follows.
    Three preparations of 131I-albumin (0.15mg-5μCi) , 131I-albumin (10mg-5μCi) and 131I-fibrinogen (0.02mg-5μCi) were injected intravenously to each group of rats transplanted subcutaneously with Yoshida's Sarcoma. These rats were sacrificed 6 hours, 12 hours, 24 hours and 48 hours after injection of 131I-albumin and were sacrificed 3 hours, 24 hours, 48hours and 72 hours after injection of 131I-fibrinogen. The radioactivities of tumor, blood, muscle, liver, kidney, lung and spleen were measured by a well-type scintillation counter, and the retention value in every tissue including tumor was calculated (in per cent of administered dose per g-tissue weight) .
    In the two groups of rats to which 131I-albumin (0.15mg-5μCi) and 131I-albumin (10mg-5μCi) were administered, retention values in the tumor and other tissues were similar with one another. The retention value in the tumor was greater than the values in any other tissues except blood, and 131I-albumin taken into the tumor was metabolized after remaining there for a while. As for 131I-fibrinogen, the retention value in the tumor was very high and 131I-fibrinogen taken into the tumor was hardly metabolized, remaining there for a long time.
    In the experiment using rats intraperitoneally transplanted with Yoshida's Sarcoma, 131I-albumin and 131I-fibrinogen were hardly taken into ascites cells of Yoshida's Sarcoma.
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  • Yoichiro OHMOMO, Masamichi SAIKI
    1970Volume 19Issue 6 Pages 282-285
    Published: June 15, 1970
    Released on J-STAGE: September 07, 2010
    JOURNAL FREE ACCESS
    Experiment was carried out in order to know the distribution of 131I in milk and the secretion into milk from lactating Holstein cows after a single intravenous administration. It was recognized that about 26% and 61% of dosed 131I was recovered during the 6 days following administration from milk of Holstein (A) and (B) respectively.
    About 2% and 20% of 131I were found in fat and protein fractions respectively and no regular variation was observed on the distribution pattern as a function of time after administration.
    From those considerations it was concluded that Glascock's assumption would be acceptable and consequently the composite system of ion exchange treatment and CCl4 extraction would be also acceptable as a rapid and convenient method for the determination of 131I in milk previously recommended by the authors.
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  • Masatoshi TAKAMATSU
    1970Volume 19Issue 6 Pages 286-289
    Published: June 15, 1970
    Released on J-STAGE: July 21, 2010
    JOURNAL FREE ACCESS
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  • Yoiti TITANI, Tomoo TAKAHASHI, Kenji YAMAGUCHI
    1970Volume 19Issue 6 Pages 290-293
    Published: June 15, 1970
    Released on J-STAGE: July 21, 2010
    JOURNAL FREE ACCESS
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  • Tomitaro ISHIMORI
    1970Volume 19Issue 6 Pages 294-300
    Published: June 15, 1970
    Released on J-STAGE: July 21, 2010
    JOURNAL FREE ACCESS
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  • Hideyo SUZUKI
    1970Volume 19Issue 6 Pages 301-309
    Published: June 15, 1970
    Released on J-STAGE: July 21, 2010
    JOURNAL FREE ACCESS
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  • 1970Volume 19Issue 6 Pages A1059-A624
    Published: June 15, 1970
    Released on J-STAGE: July 21, 2010
    JOURNAL FREE ACCESS
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